Toxicity of Intravitreally Administered Alpha-Interferon

Dharma, Shashi; Peyman, Gholam A.; Vernot, Jackie; Fiscella, Richard G.

doi:10.3928/1542-8877-19870101-15

Ophthalmic Surg Lasers Imaging

1987

DOI: 10.3928/1542-8877-19870101-15

|View full text |Cite

Toxicity of Intravitreally Administered Alpha-Interferon

Shashi Dharma¹,

Gholam A. Peyman²,

Jackie Vernot³

et al.

Abstract: We studied the toxicity of single doses of intravitreally administered alpha-interferon in albino rabbits. Doses of 420.000, 210,000, 105,000, 52,500 , and 26,250 units/0.1 cc showed no significant histologic changes by light microscopy or altered retinal function assessed by photopic and scotopic electroretinography.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

1992

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Management of Viral Retinitis

Schulman¹,

Peyman²

1988

Ophthalmic Surg Lasers Imaging

View full text Add to dashboard Cite

Cytomegalovirus, herpes simplex, and herpes zoster are responsible for the majority of cases of viral retinitis. Herpes zoster also has been strongly incriminated as a causal agent in acute retinal necrosis. Effective chemotherapy exists for retinitis caused by herpes simplex and herpes zoster, along with acute retinal necrosis. Conventional antiviral therapy and i mm u nomodulators are ineffective in the treatment of cytomegalovirus retinitis in patients with acquired immune deficiency disorder. Ganciclovir, a new antiviral agent, has significantly reduced visual morbidity in these patients. Recurrence of the infection is not uncommon while patients are on the drug or when the agent is discontinued, because ganciclovir is virostatic and does not stop viral replication in the retina. The inability to control this viral retinitis using presently available chemotherapy indicates a need to examine other therapeutic modalities.

show abstract

Management of Viral Retinitis

Schulman¹,

Peyman²

1988

Ophthalmic Surg Lasers Imaging

View full text Add to dashboard Cite

show abstract

Lack of Toxicity of Intravitreally Administered Interferon Alpha-2a

Karaçorlu¹,

Peyman²,

Cruz³

et al. 1992

Ophthalmic Surg Lasers Imaging

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Toxicity of Intravitreally Administered Alpha-Interferon

Cited by 2 publications

References 24 publications

Management of Viral Retinitis

Management of Viral Retinitis

Lack of Toxicity of Intravitreally Administered Interferon Alpha-2a

Contact Info

Product

Resources

About