Toxicity of Irinotecan-Eluting Beads in the Treatment of Hepatic Malignancies: Results of a Multi-Institutional Registry

Abstract

DEBIRI is safe when appropriate technique and treatment are used. Adverse events can be predicted based on pretreatment- and treatment-related factors, and their occurrence can become part of the informed consent process. Continued standardization of this treatment will lead to fewer adverse events and improved patient quality of life.

Pulmonary artery chemoembolization in a sheep model: Evaluation of performance and safety of irinotecan eluting beads (DEB‐IRI)

“…33 By comparison, after hepatic transarterial embolization using DEB-IRI loaded with 100 mg irinotecan, no severe systemic side effect due to SN38 has been reported in humans. 24,40,41 In contrast, irinotecan administered by IV route (60-100 mg) in patients with lung tumors has been associated with severe and sometimes fatal diarrhoea and neutropenia driven by intestinal and hepatic first-pass effects. [42][43][44] No sign of toxicity was seen in lung tissue after PACE with saline DEB, DEB-IRI 20, and 50.…”

Management of Postembolization Syndrome Following Hepatic Transarterial Chemoembolization for Primary or Metastatic Liver Cancer

“…Transarterial chemoembolization is now a prominent and standard palliative treatment option for nonresectable liver metastases from primary colorectal cancer, other liver primary neoplasms (cholangiocarcinoma), neuroendocrine tumors, ocular melanoma, and breast cancer, 1,2 achieving demonstrated improvement in quality of life (QOL) through symptom management and overall survival time. 3 The high safety profile and clinical effectiveness of TACE have therefore meant that it is a viable treatment option for patients with incurable disease. 3 Transarterial chemoembolization is also referred to as hepatic artery chemoembolization and hepatic arterial infusion chemotherapy, but in this review, the term TACE will be used for all of these procedures.…”

“…3 The high safety profile and clinical effectiveness of TACE have therefore meant that it is a viable treatment option for patients with incurable disease. 3 Transarterial chemoembolization is also referred to as hepatic artery chemoembolization and hepatic arterial infusion chemotherapy, but in this review, the term TACE will be used for all of these procedures.…”

Evaluation of the Plasmatic and Parenchymal Elution Kinetics of Two Different Irinotecan-Loaded Drug-Eluting Embolics in a Pig Model

“…Pain occurs in as many as 40% of patients, fever in as many as 80%, and nausea in as many as 27% (3). Therefore, standardized supportive therapy regimens have been recommended (4,8,21). DC Bead M1 and TANDEM particles have been introduced as new drug-eluting embolic agents.…”