Toxicity of manganese metallodrugs toward Danio rerio

Arndt, Anderson; Borella, Maria Inês; Espósito, Breno Pannia

doi:10.1016/j.chemosphere.2013.07.014

Cited by 21 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, the antioxidant catalyst showed a positive effect on sarcoplasmic reticulum Ca 2+ release in Wistar rats but a negative effect on myofibrillar Ca 2+ sensitivity. On the other hand, Espósito et al [ 162 ] reported the toxicity of EUK-108 (20–100 µM dose) toward Danio rerio individuals (zebrafish), particularly in terms of brain damage. Finally, Vanfleteren et al [ 11 ] found that administration of EUK-8 to starving Escherichia coli cells surprisingly enhanced the production of ROS, resulting in a massive increase of oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

et al. 2020

View full text Add to dashboard Cite

Manganosalen complexes are coordination compounds that possess a chelating salen-type ligand, a class of bis-Schiff bases obtained by condensation of salicylaldehyde and a diamine. They may act as catalytic antioxidants mimicking both the structure and the reactivity of the native antioxidant enzymes active site. Thus, manganosalen complexes have been shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess reactive oxygen species (ROS), thereby restoring the redox balance in damaged cells and organs. Initial catalytic studies compared the potency of these compounds as antioxidants in terms of rate constants of the chemical reactivity against ROS, giving catalytic values approaching and even exceeding that of the native antioxidative enzymes. Although most of these catalytic studies lack of biological relevance, subsequent in vitro studies have confirmed the efficiency of many manganosalen complexes in oxidative stress models. These synthetic catalytic scavengers, cheaper than natural antioxidants, have accordingly attracted intensive attention for the therapy of ROS-mediated injuries. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage. These disorders, ranging from the prevention of fetal malformations to the extension of lifespan, include neurodegenerative, inflammatory, and cardiovascular diseases; tissue injury; and other damages related to the liver, kidney, or lungs.

show abstract

Section: Discussionmentioning

confidence: 99%

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…P2 also presented high levels of manganese. The toxicity of manganese in fish depends on species and, within a species, depends on the tissue, and this metal decreased the activity of CAT and SOD in the brain of some species of fish (Vieira et al, 2012;Arndt et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Enzymes from kidney, gill and brain tissues of Astyanax bimaculatus (lambari) as biomarkers of environmental impact in the Una River basin

et al. 2019

View full text Add to dashboard Cite

The Una River and its basin constitute an important water source for public supply in the municipality of Taubaté (SP, Brazil). The present work aimed to investigate biochemical markers of environmental pollution in the Una river basin using enzymes extracted from the kidneys, gills and brains of Astyanax bimaculatus, a fish commonly found in this basin. Tissue levels of superoxide dismutase (SOD), catalase (CAT), malate dehydrogenase (MDH), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE) were determined in tissues of A. bimaculatus collected in water bodies localized at Fazenda Piloto of the University of Taubaté (P1), the Remédios municipal road (P2) and at a small lake near the neighborhood of Ipiranga (P3), all located in the municipality of Taubaté. The lowest activities of renal and gill SOD were found in fish collected from P2 and P3, respectively. Renal and branchial CAT, renal MDH and LDH, as well as the activity of cerebral LDH were not affected by collection site. The activities of brain MDH and AChE were higher in fish from P3 in comparison with P1. These results along with earlier published findings, indicate that the hepatic SOD and CAT, gill SOD and LDH, muscle MDH and brain MDH and AChE are sensitive to contamination in the environment and hence can be considered as good candidate biomarkers of environmental change in the Una River basin. Enzimas dos tecidos renal, branquial e cerebral deAstyanax bimaculatus (lambari) como biomarcadoras do impacto ambiental na Bacia Hidrográfica do Rio Una RESUMO O rio Una e sua bacia hidrográfica constituem importante fonte de água para o Rev. Ambient. Água vol. 7 (supplement) -Taubaté 2019Palavras-chave: biomarcador, enzimas, poluição da água.

show abstract

“…In this case, the antioxidant catalyst showed a positive effect on sarcoplasmic reticulum Ca 2+ release in Wistar rats but a negative effect on myofibrillar Ca 2+ sensitivity. On the other hand, Espósito et al [166] reported the toxicity of EUK-108 (20-100 M dose) toward Danio rerio individuals (zebrafish), particularly in terms of brain damage. Finally, Vanfleteren et al [11] found that administration of EUK-8 to starving Escherichia coli cells surprisingly enhanced the production of ROS, resulting in a massive increase of oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review

Rouco¹,

Pedrido²,

Maneiro³

2020

Preprint

View full text Add to dashboard Cite

Manganosalen complexes are coordination compounds that possess a chelating salen-type ligand, a class of bis-Schiff bases obtained by condensation of salicylaldehyde and a diamine. They may act as catalytic antioxidants mimicking both the structure and the reactivity of the native antioxidant enzymes active site. Thus, manganosalen complexes have shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess ROS, thereby restoring the redox balance in the damaged cells and organs. Initial catalytic studies compared the potency of these compounds as antioxidants in terms of rate constants of the chemical reactivity against ROS, giving catalytic values approaching and even exceeding that of the native antioxidative enzymes. Although most of these catalytic studies lack of biological relevance, subsequent in vitro studies have confirmed the efficiency of many manganosalen complexes in oxidative stress models. These synthetic catalytic scavengers, cheaper than natural antioxidants, have accordingly attracted intensive attention for the therapy of ROS-mediated injuries. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage. This disorders, ranging from the prevention of fetal malformations to the extension of lifespan, include neurodegenerative, inflammatory and cardiovascular diseases, tissue injury, and other damages related to liver, kidney or lungs.

show abstract

Toxicity of manganese metallodrugs toward Danio rerio

Cited by 21 publications

References 38 publications

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

Enzymes from kidney, gill and brain tissues of Astyanax bimaculatus (lambari) as biomarkers of environmental impact in the Una River basin

Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review

Contact Info

Product

Resources

About