Toxicity of methimazole on femoral bone in suckling rats: Alleviation by selenium

Amara, Ibtissem Ben; Troudi, Afef; Soudani, Nejla; Guermazi, F.; Zeghal, Najiba

doi:10.1016/j.etp.2010.08.005

Cited by 8 publications

(3 citation statements)

References 75 publications

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“…On the other hand, Se is related to protein metabolism, and in fact, Se intake improves the protein utilization. This action is also related to an increase in the growth rate (Chaudhary et al., ), and specifically, Se supplementation improves kidney histoarchitecture (Ben Amara et al., ).…”

Section: Resultsmentioning

confidence: 99%

Selenium or Selenium Plus Folic Acid–Supplemented Diets Ameliorate Renal Oxidation in Ethanol‐Exposed Pups

Ojeda

Nogales

Murillo

et al. 2012

Alcoholism Clin & Exp Res

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Section: Resultsmentioning

confidence: 99%

Selenium or Selenium Plus Folic Acid–Supplemented Diets Ameliorate Renal Oxidation in Ethanol‐Exposed Pups

Ojeda

Nogales

Murillo

et al. 2012

Alcoholism Clin & Exp Res

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“…The homogenised samples were prepared as previously described [11] [12]. RIPA buffer, as opposed to potassium phosphate buffer, was used to obtain a 20% bone concentration, with an addition of butyl-hydroxytoluene (BHT; Sigma-Aldrich) and protease inhibitors.…”

Section: Preparation Of Homogenised Bone Tissue Samplesmentioning

confidence: 99%

The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium

Ibrahim¹,

Tarboush²,

Aljada³

et al. 2014

FNS

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This study examined the effect of selenium (Se) or lycopene (Lyc) and their combination on oxidative stress in bone following cadmium (Cd) exposure in vivo. Cd exposure enhanced accumulation of Cd in femur with subsequent increase in LPO and PC and decreased antioxidative enzyme activities in rat femur, along with significant decreases in body and femur bone weights. Subcutaneous (s.c.) injection of Se or Lyc reduced Cd accumulation in bone and increased body and femur weights, when given individually or concomitantly. Antioxidant enzyme activities maintained and/or increased following Se and Lyc supplementation when given individually or concomitantly. However, lycopene dose of 10 mg/kg of body weight alone or selenium alone provided better protection to bone tissues of rats against oxidative stress compared to treatment with their combination. Selenium and lycopene could be used as a dietary supplement to protect against bone oxidative stress in areas exposed to Cd pollution.

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“…The drug methimazole (MMI) is widely used to antagonize hyperthyroidism and manage Graves' disease, an autoimmune condition promoting hyperthyroidism (Cano-Europa et al 2011;Wu et al 2013). Biochemically, MMI acts by preventing iodine incorporation into the thyroid hormone precursor, thyroglobulin, and thus interferes with conversion of thyroxine (T4) to triiodothyronine (T3) (Cooper 1984;Amara et al 2012;Parisa and Fahimeh 2015). Importantly, treatment with moderate doses of MMI reportedly impairs olfactory function in rats, while high doses cause complete destruction of the olfactory epithelium (OE) (Genter et al 1995).…”

Section: Sak3 Ameliorates Methimazole-induced Cholinergic Neuronal Damentioning

confidence: 99%

SAK3-Induced Neuroprotection Is Mediated by Nicotinic Acetylcholine Receptors

Fukunaga

Yabuki

2018

Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

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Cholinergic neurotransmission plays a critical role in neuronal plasticity and cell survival in the central nervous system (CNS). Two types of acetylcholine receptors (AChRs), muscarinic AChRs (mAChRs) and nicotinic AChRs (nAChRs), trigger intracellular signaling through G protein activity and ion influx, respectively. To assess mechanisms underlying neuroprotection through nAChRs, we developed SAK3, a novel modulator of nAChR activity. Recently, we found that SAK3 enhances T-type calcium channel activity, promoting ACh release in the hippocampal CA1 region of olfactory-bulbectomized mice. Here, we observed potent SAK3 neuroprotective activity in mice with 20-min bilateral common carotid artery occlusion (BCCAO) or hypothyroidism. Treatment of mice with the α7 nAChR-selective inhibitor methyllycaconitine (0.5 mg/kg/day, p.o.) antagonized SAK3-mediated neuroprotection and memory improvement in BCCAO mice. Single administration of the anti-Graves' disease therapeutic methimazole (MMI) to female mice disrupted olfactory bulb (OB) glomerular structure, and cholinergic neurons largely disappeared in the medial septum followed by memory loss. Chronic SAK3 (0.5-1 mg/kg, p.o.) administration significantly rescued the number of cholinergic medial septum neurons in MMI-treated mice and improved cognitive deficits seen in those mice. Overall, our study suggests that, in mice, the novel nAChR modulator SAK3 can rescue neurons impaired by transient ischemia and hypothyroidism. We also address mechanisms common to SAK3-induced neuroprotection in both conditions.

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Toxicity of methimazole on femoral bone in suckling rats: Alleviation by selenium

Cited by 8 publications

References 75 publications

Selenium or Selenium Plus Folic Acid–Supplemented Diets Ameliorate Renal Oxidation in Ethanol‐Exposed Pups

Selenium or Selenium Plus Folic Acid–Supplemented Diets Ameliorate Renal Oxidation in Ethanol‐Exposed Pups

The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium

SAK3-Induced Neuroprotection Is Mediated by Nicotinic Acetylcholine Receptors

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