Toxicity of Oxazolidinone Linezolid on Pathogenic Microorganism Listeria ivanovii

Abstract

Oxazolidinone, a new class of antimicrobial agents is active against various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), penicillin-resistant Streptococcus pneumoniae (PRSP) and vancomycin-resistant Enterococci (VRE). Sensitivity of Oxazolidinone Linezolid was studied against pathogenic microorganism Listeria ivanovii and Minimum Inhibitory Concentration (MIC) determined by broth dilution method and Hi-Comb method was 10 µg/ml. Morphological alterations on Listeria ivanovii cell surface were seen by Scanning Electron Microscopy (SEM) after treatment with Linezolid. Inhibition on the activity of dehydrogenases of organism by Linezolid was also studied in the present study.