Toxicity of PBBs with special reference to porphyrinogenic action and spectral interaction with hepatic cytochrome P-450.

Strik, J.J.T.W.A.

doi:10.1289/ehp.7823167

Cited by 17 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their occurence in PBB intoxication is interesting because of the various hepatic enzyme parameters affected by PBB. PBB has been shown to stimulate mitochondrial heme synthesis, resulting in porphyria (Strik 1978). These stimulated enzyme activities, may be the initiating stimulus for inclusion formation.…”

Section: Discussionmentioning

confidence: 99%

The presence of hepatic intramitochondrial crystalline inclusions in polybrominated biphenyl-treated mice

et al. 1980

View full text Add to dashboard Cite

Electron microscopic study of livers from mice fed 167 ppm polybrominated biphenyl (PBB) revealed mitochondrial abnormalities which consisted of both alterations in size and the formation of crystalline-like inclusions within the mitochondrial matrix. These inclusions appeared as parallel arrays of rods and were found in elongated mitochondria which contained few cristae. The findings are briefly described and the possible significance of such inclusions in relation to mitochondrial aberrations are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

The presence of hepatic intramitochondrial crystalline inclusions in polybrominated biphenyl-treated mice

et al. 1980

View full text Add to dashboard Cite

show abstract

Porphyria in herring gulls: A biochemical response to chemical contamination of great lakes food chains

Fox

Norstrom

Wigfield

et al. 1988

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Concentrations of highly carboxylated porphyrins (HCPs) in the livers of adult herring gulls (Larus argentatus) from colonies throughout the Great Lakes were found to be markedly elevated in comparison with those in gulls from coastal areas and in seven other species of birds consuming diets uncontaminated with polyhalogenated aromatic hydrocarbons (PHAHs). The highes levels were found in gulls from lower Green Bay (Lake Michigan), Saginaw Bay (Lake Huron) ant Lake Ontario. We suggest that the high levels of HCPs reflect PHAH‐induced derangement of heme biosynthesis. Determination of HCPs offers promise as a specific and sensitive biological marker of PHAH‐induced toxicity and as a measure of the toxicological significance of the chemical burden in gulls, terminal members of Great Lakes food chains.

show abstract

Genetic, Metabolic, and Biochemical Aspects of the Porphyrias

Sassa

Kappas

1981

Advances in Human Genetics 11

View full text Add to dashboard Cite

Toxicity of PBBs with special reference to porphyrinogenic action and spectral interaction with hepatic cytochrome P-450.

Abstract: Some of the polyhalogenated aromatic compounds (PHAs) which are able to produce porphyria are presently known as environmental contaminants.

Cited by 17 publications

References 28 publications

The presence of hepatic intramitochondrial crystalline inclusions in polybrominated biphenyl-treated mice

The presence of hepatic intramitochondrial crystalline inclusions in polybrominated biphenyl-treated mice

Porphyria in herring gulls: A biochemical response to chemical contamination of great lakes food chains

Genetic, Metabolic, and Biochemical Aspects of the Porphyrias

Contact Info

Product

Resources

About