Toxicity of PEG-Coated CoFe2O4 Nanoparticles with Treatment Effect of Curcumin

Akhtar, Shahnaz; An, Wei; Niu, Xiaoying; Li, Kang; Anwar, Shahzad; Khan, Maaz; Maqbool, Muhammad; Gao, Lan

doi:10.1186/s11671-018-2468-7

Cited by 17 publications

(7 citation statements)

References 29 publications

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“…In the figure, it is seen that the expression levels of ALT, AST, BUN, CREA, CYS-C, and TB were approached towards the normal values after the administration of curcumin. This can be attributed to the fact that curcumin has strong antioxidant characteristics which reduces the oxidative stress produced as a result of the toxicity induced by cobalt ferrite [47]. It has also been reported that TNF-α and IL-1 play important role in the induction of hepatic necrosis and curcumin reduces the effect of toxicity by inhibiting the secretion of TNF-α and IL-1 by macrophages [48], similar to the work reported earlier in Ref.…”

Section: Resultssupporting

confidence: 68%

“…For preparation of PEG-coated cobalt ferrite nanoparticles, we adopted hydrothermal technique [40, 47]. For this purpose, solutions of cobalt chloride (0.2 M) and ferric nitrate (0.4 M) were prepared separately in 25 mL deionized (DI) water each and then these solutions were mixed with 25 mL aqueous solutions of polyethylene glycol (2.5 mM) and sodium hydroxide (3 M), respectively.…”

Section: Methodsmentioning

confidence: 99%

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RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles

et al. 2019

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We present a comparative study of the toxicity of polyethylene glycol (PEG)–coated cobalt ferrite nanoparticles and nanospheres. Nanoparticles were prepared by hydrothermal method while nanospheres were prepared by solvothermal technique. The surface of nanomaterials was successfully modified with polyethylene glycol. To investigate the morphology of the prepared samples, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, thermogravimetric analysis (TGA), and electron microscopy techniques were employed. Structural analyses confirmed the formation of polycrystalline cobalt ferrite nanoparticles with diameters in the range 20–25 nm and nanospheres in the range 80–100 nm, respectively. Kunming SPF mice (female, 6–8 weeks old) were used to investigate the toxicity induced by cobalt ferrite nanoparticles and nanospheres in different organs of the mice. Biodistribution studies, biochemical indices, histopathological assessments, inflammatory factors, oxidation and antioxidant levels, and cytotoxicity tests were performed to assess the toxicity induced by cobalt ferrite nanoparticles and nanospheres in mice. Cobalt ferrite nanospheres were found to be more toxic than the nanoparticles and curcumin was proved to be a good healing agent for the toxicity induced by PEG-coated cobalt ferrite nanomaterials in mice.

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Section: Resultssupporting

confidence: 68%

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles

et al. 2019

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“…These results surge the defensive process and possible cell death in macrophages with the administration of foreigner elements. Overall results reveal no remarkable alterations nor cause any damage to cell membranes 37,38 …”

Section: Resultsmentioning

confidence: 85%

Biotransformation and toxicity evaluation of functionalized manganese doped iron oxide nanoparticles

et al. 2021

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Safe inorganic nanomaterials are tremendously used for diagnosis and therapies. However, essential processing in the microbiological environment changed the physical properties and in situ degradability, which is evaluated meticulously. In this research article, bare, Polyethylene glycol, and citrate coated manganese doped iron oxide nanoparticles are synthesized through the coprecipitation route. Structural, magnetic, optical, and morphological analyses are performed through different characterization tools. X‐ray diffraction confirmed the formation of single‐phase FeMnO3 with a crystallite size of 48.91 nm. Vibrating sample magnetometer analysis confirmed the formation of soft ferromagnetic behavior of bare and coated nanoparticles (NPs). Scanning electron microscopy and transmission electron microscopy confirmed the formation of spherical shaped nanoparticles. Single‐dose in vivo acute toxicity testing is performed through the intraperitoneal route of administration on groups of healthy albino rats. Elevated enzyme levels of kidney and liver are observed at day 1 but a transient decrease is observed at later stages. Through optical follow‐up, degradation effects are studied by adding prepared NPs in lysosomal like medium. Finally, metabolization of degraded products based on manganese/iron ions is studied by adding apoferritin into a lysosome like solution. These studies showed partial storage of manganese ions from NPs, while no substantial transfer is observed in the case of manganese salt.

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“…Transient increase observed after administration of NPs might be due to iron/cobalt ion formation due to chemical degradation in the nucleus of cells. Intracellular distribution of NPs might lead to the biodegradation process, which may increase the defensive process and cell death as observed in macrophage results (Akhtar et al 2018;Jaiswal et al 2014). Kidney function analysis revealed that no significant alterations or membrane damages are observed after administration of bare and coated NPs.…”

Section: Kidney Function Testmentioning

confidence: 92%

Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins

et al. 2020

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In the biological environment, the fate of nanomaterials characterizes as critical matter, which regulates environmental effects and associated hazards for humans. Understanding of the nanoparticle's degradation, transformations and persistence may predict these risks. Safely designed inorganic nanomaterials are being focused for therapy; yet, fundamental processing in the biological environment and physical properties have not been assessed thoroughly. In this research work, bare, polyethylene glycol and citrate-coated cobalt ferrite nanoparticles (NPs) are prepared through modified chemical coprecipitation method. Structural, elemental, magnetic and morphological analysis of synthesized samples are performed through XRD, EDX, FTIR, VSM, SEM and TEM. XRD confirms the cubic structure of CoFe 2 O 4 with crystallite size 25.75 nm. SEM and TEM confirm the formation of faceted cube-like morphology. For in vivo toxicity studies, a single dose of bare and coated cobalt ferrite NPs are intraperitoneally administrated in healthy albino rats. The degradation effects are studied through optical followup, by introducing bare and coated NPs in lysosomal-like media where changes in behavior are linked with transformations in vivo. Transfer of degraded ions of cobalt ferrite NPs into apoferritin are also evaluated. Apoferritin studies reveal partial filling of protein with cobalt ions from cobalt ferrite NPs.

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Toxicity of PEG-Coated CoFe2O4 Nanoparticles with Treatment Effect of Curcumin

Cited by 17 publications

References 29 publications

RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles

RETRACTED ARTICLE: A Comparative Study of the Toxicity of Polyethylene Glycol–Coated Cobalt Ferrite Nanospheres and Nanoparticles

Biotransformation and toxicity evaluation of functionalized manganese doped iron oxide nanoparticles

Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins

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