Toxicity of Piper aduncum L. (Piperales: Piperaceae) from the Amazon forest for the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)

Silva, Wilson Castro; Martins, João Ricardo; Souza, Hellen Emilia Menezes de; Heinzen, Horacio; Cesio, María Verónica; Mato, Mauricio; Albrecht, Francine; Azevedo, João Lúcio de; Barros, Neiva Monteiro de

doi:10.1016/j.vetpar.2009.06.006

Cited by 74 publications

(43 citation statements)

References 52 publications

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“…These alternatives may include new chemistry and/or the identification of novel or underutilized biochemical targets. Several essential oils have been shown to be toxic to the cattle fever tick (R. annulatus) and to the southern cattle tick (R. microplus) [8,22,26,36,37,39,40,46]. Here, we report on the development of an expression system for the southern cattle tick's tyramine receptor (RmTAR1), and present evidence that this receptor may be a potential target of biopesticides.…”

Section: Discussionmentioning

confidence: 96%

“…Recently, there has been a growing interest in the use of botanical acaricides, particularly essential oils, to control R. microplus and R. annulatus [8,22,26,36,37,39,40,46]. For instance, the essential oil from cumin seeds (Cuminum cyuminum) and allspice berries (Pimenta dioica) resulted in 100% mortality at concentrations between 2.5% and 20% (v/v).…”

Section: Introductionmentioning

confidence: 99%

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Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target

Gross

Temeyer

Day

et al. 2017

Chemico-Biological Interactions

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a b s t r a c tAn outbreak of the southern cattle tick, Rhipicephalus (Boophilus) microplus, (Canestrini), in the United States would have devastating consequences on the cattle industry. Tick populations have developed resistance to current acaricides, highlighting the need to identify new biochemical targets along with new chemistry. Furthermore, acaricide resistance could further hamper control of tick populations during an outbreak. Botanically-based compounds may provide a safe alternative for efficacious control of the southern cattle tick. We have developed a heterologous expression system that stably expresses the cattle tick's tyramine receptor with a G-protein chimera, producing a system that is amenable to high-throughput screening. Screening an in-house terpenoid library, at two screening concentrations (10 mM and 100 mM), has identified four terpenoids (piperonyl alcohol, 1,4-cineole, carvacrol and isoeugenol) that we believe are positive modulators of the southern cattle tick's tyramine receptor.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target

Gross

Temeyer

Day

et al. 2017

Chemico-Biological Interactions

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“…Larvae mortality was evaluated at concentrations of 1 to 20 mg.mL -1 (≈ 0.1 to 2%), and was found to be 70.42, 40.5 and 17.2% in the hexanic, ethanolic and ethyl acetate extracts, respectively, at the highest concentration. Hydrodistillation of the hexanic extract produced 6.8% essential oil, 94.84% consisting on the sesquiterpene dill apiol, which caused 100% larval mortality at 0.1 mg.mL -1 (≈ 0.01%) (SILVA et al, 2009). The essential oil of Piper mikanianum (LC 50 2.33 µL.mL -1 ; ≈ 0.233%) was more active against larvae than that of Piper xylosteoides (LC 50 6.15 µL.mL -1 ; ≈ 0.615%), while the oil of Piper amalago was inactive.…”

Section: In Vitro Testsmentioning

confidence: 99%

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Borges

Sousa

Barbosa

2011

Rev. Bras. Parasitol. Vet.

113

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The evolution of resistance of Rhipicephalus (Boophilus) microplus to synthetic acaricides has given rise to the need for new scientific investigations on alternative ways to control this tick. In this regard, various studies on plants have been developed in an attempt to find extracts with acaricidal properties. Evaluations on plant extracts for controlling R. (B.) microplus have grown intensely over the last decade. There are many advantages from using plant extracts: for example, they can be used in organic cattle farming or even replace synthetic acaricides and they are associated with lower environmental and food contamination, slower development of resistance and lower toxicity to animals and humans. In vitro studies on plant extracts have shown promising results, but most of these extracts have not been tested on animals to validate their use. Difficulties in preparing proper formulations, differences in the chemical composition of plants of the same species due to extrinsic and intrinsic factors and sparse information on active acaricide compounds are hindrances that need to be addressed in order to enable progress within this scientific field.Keywords: Phytotherapy, cattle tick, Rhipicephalus (Boophilus) microplus, in vitro bioassays, in vivo bioassays. ResumoA evolução da resistência do Rhipicephalus (Boophilus) microplus aos acaricidas sintéticos tem impulsionado novas investigações científicas sobre métodos alternativos para controlar este carrapato. Considerando isso, vários estudos com plantas têm sido desenvolvidos numa tentativa de encontrar extratos com propriedades acaricidas. Avalições de extratos de plantas para o controle de R. (B.) microplus tem sido intensificadas nesta última década. Existem muitas vantagens com o uso de extratos de plantas no controle deste carrapato, como: eles podem ser utilizados na produção orgânica de bovinos, ou mesmo substituir os acaricidas sintéticos, além do mais, estão associados com baixa contaminação ambiental e dos alimentos, desenvolvimento mais lento de resistência e baixa toxicidade para animais e seres humanos. Estudos in vitro de extratos de plantas têm apresentado resultados promissores, mas a maioria destes extratos não têm sido testada em animais para validar estes resultados. Dificuldades para preparar formulações apropriadas, diferenças na composição química de plantas de uma mesma espécie devido a fatores intrínsecos e extrínsecos e informações esparsas.sobre os princípios ativos são entraves que precisam ser solucionados visando o desenvolvimento deste campo de pesquisa.Palavras-chave: Fitoterapia, carrapato de bovinos, Rhipicephalus (Boophilus) microplus, testes in vitro, testes in vivo.

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“…3 Ticks are blood sucking heamatophagous ectoparasites, transmiting many diseases affecting livestock, humans and companion animals. 4 They cause significant loss in livestock industries through reduction of milk production, weight gain and reproductive efficacy 5 and also increa sed the incidence of life threatening diseases in human. Chemical acaricides are used for control of tick population throughout the world.…”

Section: Introductionmentioning

confidence: 99%

Pharmaco-Chemical characterization and Acaricidal Activity of Ethanolic Extract of Chassalia Curviflora (Wall ex Kurz.) Thwaites

Palayullaparambil¹,

Palayullaparambil²,

Juliet³

et al. 2016

Phcogj

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Introduction: C. curviflora, an important ethno-medicinal plant used by the Kurichia local people in Western Ghats region of Wayanad is yet to be explored pharmacologically. It is used as paste on the body of cattle and birds for curing skin diseases. Objectives: To characterize the pharmacochemical features and to study the acaricidal effect of ethanolic extract of C. curviflora on engorged female ticks of R. (B.) annutatus. Methods: The pharmaco-chemical features such as physico-chemical, proximate, phytochemical, fluorescence, and HPTLC profiling were carried out using standard techniques. The pulverized leaves were subjected to soxhlet extraction using ethanol. The ethanolic extract at different concentrations (10% to 1.25%) was tested against ticks using adult immersion test (AIT). Result: The preliminary phytochemical investigation showed high contents of saponins, alkaloids and flavonoids. The HPTLC profiling of ethanolic extract showed the presence of 14 polyvalent components. Based on AIT, the extract at 10% revealed 43.76% of inhibition of fecundity (IF) and 29.16%

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Toxicity of Piper aduncum L. (Piperales: Piperaceae) from the Amazon forest for the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)

Cited by 74 publications

References 52 publications

Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target

Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target

Perspectives for the use of plant extracts to control the cattle tick Rhipicephalus (Boophilus) microplus

Pharmaco-Chemical characterization and Acaricidal Activity of Ethanolic Extract of Chassalia Curviflora (Wall ex Kurz.) Thwaites

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