Toxicity of quantum dots and cadmium to rainbow trout (Oncorhynchus mykiss) in early ontogenesis

Cibulskaitė, Živilė; Rotomskis, Ričardas

doi:10.3389/conf.fmars.2015.03.00195

Front. Mar. Sci.

2015

DOI: 10.3389/conf.fmars.2015.03.00195

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Toxicity of quantum dots and cadmium to rainbow trout (Oncorhynchus mykiss) in early ontogenesis

Živilė Cibulskaitė

Ričardas Rotomskis²

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2018

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“…ions such as, zinc (Zn), copper (Cu), manganese (Mn) and iron bound to the enzymes and other biomolecules, interfere with the homeostasis of essential metals, trigger reactive oxygen species formation and disrupt the cellular function of biologically important molecules (Adiele, Stevens, & Kamunde, 2012;Kitamura & Hiramatsu, 2010;Zhang et al, 2018). Cells respond to Cd exposure with multi-strategies.…”

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Time‐dependent response of A549 cells upon exposure to cadmium

Zhao

Zhang

Zhu

et al. 2018

J of Applied Toxicology

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Cadmium is considered one of the most harmful carcinogenic heavy metals in the human body. Although many scientists have performed research on cadmium toxicity mechanism, the toxicokinetic process of cadmium toxicity remains unclear. In the present study, the kinetic response of proteome in/and A549 cells to exposure of exogenous cadmium was profiled. A549 cells were treated with cadmium sulfate (CdSO ) for different periods and expressions of proteins in cells were detected by two-dimensional gel electrophoresis. The kinetic expressions of proteins related to cadmium toxicity were further investigated by reverse transcription-polymerase chain reaction and western blotting. Intracellular cadmium accumulation and content fluctuation of several essential metals were observed after 0-24 hours of exposure by inductively coupled plasma mass spectrometry. Fifty-four protein spots showed significantly differential responses to CdSO exposure at both 4.5 and 24 hours. From these proteins, four expression patterns were concluded. Their expressions always exhibited a maximum abundance ratio after CdSO exposure for 24 hours. The expression of metallothionein-1 and ZIP-8, concentration of total protein, and contents of cadmium, zinc, copper, cobalt and manganese in cells also showed regular change. In synthesis, the replacement of the essential metals, the inhibition of the expression of metal storing protein and the activation of metal efflux system are involved in cadmium toxicity.

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mentioning

confidence: 99%

Time‐dependent response of A549 cells upon exposure to cadmium

Zhao

Zhang

Zhu

et al. 2018

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

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Toxicity of quantum dots and cadmium to rainbow trout (Oncorhynchus mykiss) in early ontogenesis

Cited by 1 publication

References 0 publications

Time‐dependent response of A549 cells upon exposure to cadmium

Time‐dependent response of A549 cells upon exposure to cadmium

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