Toxicity of silver nanoparticles against bacteria, yeast, and algae

Dorobantu, Loredana S.; Fallone, Clara J.; Noble, Adam; Veinot, Jonathan G. C.; Ma, Guibin; Goss, Greg G.; Burrell, Robert E.

doi:10.1007/s11051-015-2984-7

Cited by 110 publications

(63 citation statements)

References 32 publications

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“…44 The exact mode of action for the bactericidal effect by AgNPs remains debatable, whether AgNPs or the released Ag + are the actual active agent. 55 Most of the recent studies show that Ag + is more likely the agent causing cell death. 26,56,57 Our result here also demonstrates that Ag + , not AgNPs, ultimately causes cell death.…”

Section: Resultsmentioning

confidence: 99%

Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics

Deng

McShan

Zhang

et al. 2016

Environ. Sci. Technol.

234

134

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A combination of silver nanoparticles (AgNPs) and an antibiotic can synergistically inhibit bacterial growth, especially against the drug-resistant bacteria Salmonella typhimurium. However, the mechanism for the synergistic activity is not known. This study chooses four classes of antibiotics, β-lactam (ampicillin and penicillin), quinolone (enoxacin), aminoglycoside (kanamycin and neomycin), and polykeptide (tetracycline) to explore their synergistic mechanism when combined with AgNPs against the multidrug-resistant bacterium Salmonella typhimurium DT 104. Enoxacin, kanamycin, neomycin, and tetracycline show synergistic growth inhibition against the Salmonella bacteria when combined with AgNPs, while ampicillin and penicillin do not. UV–vis and Raman spectroscopy studies reveal that all these four synergistic antibiotics can form complexes with AgNPs, while ampicillin and penicillin do not. The presence of tetracycline enhances the binding of Ag to Salmonella by 21% and Ag+ release by 26% in comparison to that without tetracycline, while the presence of penicillin does not enhance the binding of Ag or Ag+ release. This means that AgNPs first form a complex with tetracycline. The tetracycline–AgNPs complex interacts more strongly with the Salmonella cells and causes more Ag+ release, thus creating a temporal high concentration of Ag+ near the bacteria cell wall that leads to growth inhibition of the bacteria. These findings agree with the recent findings that Ag+ release from AgNPs is the agent causing toxicity.

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Section: Resultsmentioning

confidence: 99%

Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics

Deng

McShan

Zhang

et al. 2016

Environ. Sci. Technol.

234

134

View full text Add to dashboard Cite

show abstract

“…As mentioned above, a capping agent is used for increasing the stability and facility dispersion of the metal NPs. These agents may potentially have a direct effect on the toxicity of the NPs as result of their ability to reduce the NP agglomeration [53][54][55]. It was found that, citrate-and chitosan-capped AgNPs can kill the bacteria, as a result of an accelerated generation of Ag+ from these NPs [53].…”

Section: Effect Of Capping Agents Functionalised Of Np On Antibacterimentioning

confidence: 99%

Comparison of Chemical and Biological Properties of Metal Nanoparticles (Au, Ag), with Metal Oxide Nanoparticles (ZnO-NPs) and their Applications

Abdussalam-Mohammed

2020

Adv. J. Chem. A

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Biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology, providing new possibilities in the diagnosis and treatment of human diseases. Nowadays, NPs have shown abilities to be used as alternative treatment for difficult diseases. Therefore, it is important to understand NP chemistry, preparation, interaction and possible mechanisms involved in its interaction with cancer cells and bacterial membranes. This study reports comparison between Au, Ag and ZnO NPs, and discusses their toxicity and physicochemical properties. In addition, this work aims to review different strategies of surface modification and functionalization of colloidal nanoparticles. Gold nanoparticles Silver nanoparticles Zinc oxide nanoparticles Toxicity growth Antibacterial activity Stability Capping agents

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“…The cell wall destruction that occurs from the physical interaction between NPs and the cell wall is, therefore, more detrimental for Gram-negative bacteria. Thus, though both Gram-positive and Gram-negative bacteria have a negatively charged cell wall, Gram-positive bacteria are usually more resistant to NP mechanisms of action 27,28,29 .…”

Section: Fig 6: X-ray Diffraction Pattern Of Biosynthesized Cu Nanopmentioning

confidence: 99%

Untitled

2020

IJPSR

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A major challenge in treating bacterial infections is the increasing incidence of microbial resistance to antibiotics. This poses a serious threat prompting the search for alternative strategies to treat bacterial infections. Metal nanoparticles as novel antibiotic agents hold promise because they show strong antibacterial activity against various bacterial species, including Gram-positive and Gram-negative bacteria. Green synthesis of nanoparticles offers minimization of wastage, reduction of derivatives, use of non-toxic solvent, auxiliaries and renewable feedstock. A single step, an eco-friendly, cost-effective method is used for the synthesis of copper nanoparticles (CuNPs) from 1.0 mM copper sulphate solution using extract of Ocimum sanctum (Tulsi) leaves as reducing and capping agent. UV-VIS, FESEM, FTIR and XRD were used to confirm and characterize the NPs. The biosynthesized copper NPs were phased pure and well crystalline with a simple cubic structure. Antibacterial study of the biogenic CuNPs suggests their efficacy against common human bacterial pathogen species. Gram-negative test organisms were found to be more susceptible to toxicity of biosynthesized CuNPs. Metal nanoparticles hold the promise to overcome microbial resistance due to their specific properties. QUICK RESPONSE CODE

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Toxicity of silver nanoparticles against bacteria, yeast, and algae

Cited by 110 publications

References 32 publications

Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics

Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics

Comparison of Chemical and Biological Properties of Metal Nanoparticles (Au, Ag), with Metal Oxide Nanoparticles (ZnO-NPs) and their Applications

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