Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter?

Vázquez-Muñoz, Roberto; Borrego, Belén; Juárez-Moreno, Karla; García-García, Maritza Roxana; Mota‐Morales, Josué D.; Bogdanchikova, Nina; Huerta-Saquero, Alejandro

doi:10.1016/j.toxlet.2017.05.007

Cited by 191 publications

(96 citation statements)

References 95 publications

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“…However, biocompatible and non-toxic silver nanoparticles, suitable for biological applications, have been also reported (Gautam and van Veggel, 2013; Rudramurthy et al, 2016). In the case of human intestinal cells, it has been described that silver nanoparticles could be cytotoxic at concentrations of 10 to 50 μg/mL (Chernousova and Epple, 2013; Vazquez-Muñoz et al, 2017). However, at concentrations lower than 10 μg/mL, silver nanoparticles have been reported to be non-toxic to human cells (Chernousova and Epple, 2013).…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Glutathione-Stabilized Silver Nanoparticles Against Campylobacter Multidrug-Resistant Strains

et al. 2018

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Campylobacter is the leading cause of bacterial diarrheal disease worldwide. Although most episodes of campylobacteriosis are self-limiting, antibiotic treatment is usually needed in patients with serious enteritis, and especially in childrens or the elderly. In the last years, antibiotic resistance in Campylobacter has become a major public health concern and a great interest exists in developing new antimicrobial strategies for reducing the impact of this food-borne pathogen on human health. Among them, the use of silver nanoparticles as antibacterial agents has taken on increased importance in the field of medicine. The aim of the present study was to evaluate the antimicrobial effectiveness of glutathione-stabilized silver nanoparticles (GSH-Ag NPs) against multidrug resistant (MDR) Campylobacter strains isolated from the chicken food chain (FC) and clinical patients (C). The results obtained showed that GSH-Ag NPs were highly effective against all MDR Campylobacter strains tested. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were in a range from 4.92 to 39.4 μg/mL and 9.85 to 39.4 μg/mL, respectively. Cytotoxicity assays were also assessed using human intestinal HT-29, Caco-2, and CCD-18 epithelial cells. Exposure of GSH-Ag NPs to intestinal cells showed a dose-dependent cytotoxic effect in all cell lines between 9.85 and 39.4 μg/mL. More than 60% of the tested Campylobacter strains were susceptible to GSH-Ag NPs concentrations ≤ 9.85 μg/mL, suggesting that practical inhibitory levels could be reached at low GSH-Ag NPs concentrations. Further works are needed with the purpose to evaluate the practical implications of the toxicity studies and to know more about other attributes linked to the biological compatibility. This behavior makes GSH-Ag NPs as a promising tool for the design of novel antibacterial agents for controlling Campylobacter.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Glutathione-Stabilized Silver Nanoparticles Against Campylobacter Multidrug-Resistant Strains

et al. 2018

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“…The survival rate of TB-infected animals following the combined treatment with isoniazid and AgNP was 95% and 35% in the group receiving AgNP only, compared with 100% mortality in the TB-infected control group. 133 One of the potential drawbacks of AgNPs, as four most of the inorganic nanoparticles, is their toxicity which may limit their usage in a biological context, [240][241][242] but despite the extension of use in the last decades, the evidence for the toxicity of AgNPs is still unclear. 243 However, an in depth discussion regarding the toxicity of AgNP is something that goes beyond the purpose of this manuscript.…”

Section: In Vivo Preclinical and Clinical Studiesmentioning

confidence: 99%

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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“…Structures such as nano‐rods, nanofibers, and more complex shapes such as nano‐prisms have been shown to be effective against wound pathogens such as S. aureus . The current challenge of heavy metal‐based antimicrobials is overcoming their inherent cyto‐toxicity to ensure optimal biocompatibility . There have been reports in the literature of contradictory factors that cause cyto‐toxicity due to the inconsistency of different AgNPs tested, when stems from both the synthesis and method of testing .…”

Section: Developments In Wound Treatmentmentioning

confidence: 99%

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

Dart

Bhave

Kingshott

2019

Macromolecular Bioscience

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Current wound healing treatments such as bandages and gauzes predominantly rely on passively protecting the wound and do not offer properties that increase the rate of wound healing. While these strategies are strong at protecting any infection after application, they are ineffective at treating an already infected wound or assisting in tissue regeneration. Next‐generation wound healing treatments are being developed at a rapid pace and have a variety of advantages over traditional treatments. Features such as gas exchange, moisture balance, active suppression of infection, and increased cell proliferation are all central to developing the next successful wound healing dressing. Electrospinning has already been shown to have the qualities required to be a key technique of next generation polymer‐based wound healing treatments. Combined with antimicrobial peptides (AMPs), electrospun dressings can indeed become a formidable solution for the treatment of both acute and chronic wounds. The literature on combining electrospinning and AMPs is now starting to increase and this review aims to give a comprehensive overview of the current developments that combine electrospinning technology and AMPs in order to make multifunctional fibers effective against infection in wound healing.

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Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter?

Cited by 191 publications

References 95 publications

Antibacterial Activity of Glutathione-Stabilized Silver Nanoparticles Against Campylobacter Multidrug-Resistant Strains

Antibacterial Activity of Glutathione-Stabilized Silver Nanoparticles Against Campylobacter Multidrug-Resistant Strains

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications

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