Toxicity of Single-Walled Carbon Nanohorns

Abstract

We extensively investigated in vitro and in vivo the toxicities of as-grown single-walled carbon nanohorns (SWNHs), a tubular nanocarbon containing no metal impurity. The SWNHs were found to be a nonirritant and a nondermal sensitizer through skin primary and conjunctival irritation tests and skin sensitization test. Negative mutagenic and clastogenic potentials suggest that SWNHs are not carcinogenic. The acute peroral toxicity of SWNHs was found to be quite low--the lethal dosage for rats was more than 2000 mg/kg of body weight. Intratracheal instillation tests revealed that SWNHs rarely damaged rat lung tissue for a 90-day test period, although black pigmentation due to accumulated nanohorns was observed. While further toxicological assessments, including chronic (repeated dose), reproductive, and developmental toxicity studies, are still needed, yet the present results strongly suggest that as-grown SWNHs have low acute toxicities.

Therapeutic applications of low-toxicity spherical nanocarbon materials

“…23,90,93,94,99 In further animal tests, no abnormal body weight or clinical symptoms (including skin and eye irritation and lung tissue damage) were observed after the administration of SWNHs. 92,130 Negative mutagenic and clastogenic results suggest that SWNHs are not carcinogenic. Moreover, histopathological examinations revealed that SWNHs were retained in the liver, lungs and spleen of the tested animals.…”

An Overview of Nanotoxicology

“…Toxicological assessments of as-grown Single-walled Carbon Nanohorns (SWNHs) investigated by Miyawaki et al, under different exposure pathways. Results indicated that SWNHs have low toxicity because SWNHs not include metal catalyst [33].…”

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

“…KNT'lerin fare ve sıçanlara uygulandığı birkaç çalışmada, akciğer, karaciğer ya da dalak gibi majör organlarda KNT birikiminden kaynaklanan olumsuz etkiler görülmüş-tür. Bu çalışmalarda KNT toksisitesinin uygulanma yoluyla da ilgili olabildiği de rapor edilmektedir (97)(98)(99)(100)(101)(102). KNT'lerin akciğer plevra dokusu ve mezotelyoma üzerine etkisi hakkındaki in vivo, in vitro ve de novo çalışmalar ise yok denecek kadar azdır (103).…”