Toxicity of subacute oral administration of cypermethrin in rats with special reference to histopathological changes

Grewal, G. S.; Verma, Pawan Kumar; Dhar, Vir Ji; Srivastava, A. K.

doi:10.4103/0973-8258.59735

Cited by 14 publications

(11 citation statements)

References 15 publications

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“…Maximum decline produce hepatotoxicity. High plasma concentrations of st of 29.2% was observed on 21 day of treatment which ALT and AST are considered as an index of liver was comparatively higher than fenvalerate (20.5%) damage [22]. An increase of aminotransferase activity and sodium nitrate (7.69%) exposed groups.…”

Section: Introductionmentioning

confidence: 92%

Evaluation of biochemical alterations produced by combined exposure of fenvalerate and nitrate in Bubalus bubalis

Gill¹,

Sandhu²,

Kaur³

2014

Vet World

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Aim: Evaluation of combined effect of fenvalerate and nitrate on biochemical parameters in buffalo calves. Materials and Methods:Sixteen male buffalo calves were divided into four groups of four calves each. Group I receiving no treatment served as the control. Group II and III animals were orally administered with fenvalerate (1.0 mg/kg/day) and sodium nitrate (20 mg/kg/day), respectively, for 21 consecutive days and were kept as positive control. Group IV animals were co-administered with fenvalerate and sodium nitrate at the above dose rates for 21 consecutive days. Biochemical parameters including Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Gamma-glutamyl transpeptidase (GGT), Lactate dehydrogenase (LDH), Glucose, Total protein, Albumin, Cholesterol, Blood urea nitrogen (BUN) and Creatinine were th determined on 0, 3, 7, 10, 14, 17 and 21 day of treatment. Estimation of these parameters was also done on 7 day of posttreatment period.Results: Co-administration of fenvalerate and sodium nitrate produced significant increase in the plasma levels of AST, ALP, GGT, LDH, glucose, BUN, cholesterol and creatinine while significant decrease in the plasma levels of total proteins was observed. No significant alteration was observed in albumin levels. Extent of organ damage as evidenced by biochemical alterations was more pronounced in calves exposed to combination of fenvalerate and sodium nitrate as compared to their individual exposures. Conclusion:Fenvalerate and sodium nitrate co-administration potentiates the toxicological injury produced, in comparison to their individual exposure.

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Section: Introductionmentioning

confidence: 92%

Evaluation of biochemical alterations produced by combined exposure of fenvalerate and nitrate in Bubalus bubalis

Gill¹,

Sandhu²,

Kaur³

2014

Vet World

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“…Histopathological study revealed that hepatocytes undergo atrophy and sever necrosis and destruction with infiltration of polymorph nuclear leucocytes dependent manner. Similarly, (24) were marked diffuse necrosis of hepatic tissue in all cypermethrin treated in rats. While the evident that cypermethrin produced hemorrhage and congestion were found in liver, agree with (12).…”

Section: Discussionmentioning

confidence: 77%

Study of some toxicological aspects of Alfa-cypermethrin in rabbits

Al-Nakeeb¹

2010

QJVMS

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This study was conducted to evaluate the immediate alterations that occur in rabbits after acute toxicity with single oral dose of cypermethrin. Twenty one rabbits were randomly divided into three equal groups: treated groups (A1), (A2) and control group used in this study. Groups (A1), (A2) received orally cypermethrin in dose of (25, 50 mg/kg body weight) respectively, While control group received normal saline at same time. Most obvious clinical sings in the treated groups were Restlessness, salivation, licking of legs and face, frequent urination, muscular tremor, incoordination, and ataxia appeared in dose dependent manner. In addition, significantly increased in respiratory rate and heart rate in treated groups compared with control group and appeared petechial hemorrhage and congestion in the conjunctiva in treated groups. The blood samples were taking to evaluate some of blood parameters includes (RBC counts, WBC counts, PLT counts, Hb concentration, PCV, RBCs indices (MCV, MCH, MCHC, RDW -CV and RDW -SD), PDW, MPV, P-LCR and some biochemical study as ALT and AST. Two rabbits from each group were killed to evaluate the histopathological alteration in liver. The statistical analysis revealed that there were significant decreased in RBC counts and Hb concentration (P<0.05) in treated groups (A1), (A2) as compared with control group. The PCV percentage, platelet counts and MCHC values revealed significant decreased (P<0.05) between group (A2) and control group. The RDW-SD, RDW-CV valves were significantly increased (p<0.05) between group (A1) and control group. Other parameter studied did not show significant differences between treated groups and control group. The statistical analysis revealed that the levels of ALT and AST were significantly elevated (P<0.05) in (A1 and A2) groups as compared with control group. In gross appearance there were petechial hemorrhage and erosion of liver parenchyma. Histopathological study revealed that there were engorgement of hepatic vein with presence of extravasated RBCs between the hepatocytes in group (A1), while group (A2) the hepatocytes undergo atrophy and severe necrosis and destruction with infiltration of polymorphnuclear leukocytes and engorgement of some portal trait with bile secretion.

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“…These changes may be attributed to increased peroxidation of polyunsaturated fatty acids. Previous studies have suggested that cypermethrin induces histopathological changes in liver [46,65]. These changes are possibly due to oxidative stress induced by cypermethrin toxicity.…”

Section: Discussionmentioning

confidence: 93%

Ameliorative role of melatonin against cypermethrin induced hepatotoxicity and impaired antioxidant defense system in Wistar rats

Gk¹,

Ips²,

Nk³

et al. 2014

IOSRJESTFT

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Recently, melatonin has attracted attention because of their strong free radical scavenging and antioxidant properties. The present study was designed to investigate the role of melatonin against cypermethrin induced hepatotoxicity in rats using qualitative, quantitative and biochemical approaches. Adult female Wistar rats were randomly divided into four groups; each group consists of six animals. Control group received vehicle, corn oil; Cypermethrin (CM) [250mg/kg bw]; Melatonin (MEL) [10 mg/kg bw]; CM+MEL treated group. Animals were treated orally, daily for a period of 4 weeks. Animals were sacrificed by decapitation and liver was used for various biochemical and histopathological examinations. The result of this study shows that in vivo administration of cypermethrin caused a significant induction of oxidative damage in liver tissue as evidenced by depletion of proteins, glutathione (GSH) and increased lipid peroxidation in hepatic tissue. Cypermethrin administration significantly enhanced the activities of enzymatic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) glutathione reductase (GR) and glutathione-Stransferase (GST). Cypermethrin intoxication exhibited elevation in the activities of liver marker enzymes such as serum glutamate pyruvate transaminase (SGPT) serum glutamate oxaloacetate transaminase (SGOT) and Lactate dehydrogenase (LDH). Furthermore, the co-administration of melatonin mitigates the hepatotoxicity of cypermethrin by normalizing the biochemical and enzymatic parameters. The biochemical observations were supported by histopathological examination of liver. The findings of this investigation suggest that the melatonin may play a protective role against cypermethrin induced hepatotoxicity and oxidative damage in female albino rats.

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Toxicity of subacute oral administration of cypermethrin in rats with special reference to histopathological changes

Cited by 14 publications

References 15 publications

Evaluation of biochemical alterations produced by combined exposure of fenvalerate and nitrate in Bubalus bubalis

Evaluation of biochemical alterations produced by combined exposure of fenvalerate and nitrate in Bubalus bubalis

Study of some toxicological aspects of Alfa-cypermethrin in rabbits

Ameliorative role of melatonin against cypermethrin induced hepatotoxicity and impaired antioxidant defense system in Wistar rats

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