Toxicity of Synthetic Musks to Early Life Stages of the Freshwater Mussel Lampsilis cardium

Gooding, Meredith P.; Newton, Teresa J.; Bartsch, Michelle R.; Hornbuckle, Keri C.

doi:10.1007/s00244-005-0223-4

Cited by 62 publications

(24 citation statements)

References 26 publications

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“…However, null mortality in the control treatment implies good health status of tested juveniles. Most toxicity studies use survival as the test endpoint, although most researchers recognize the need to develop sublethal biomarkers for these animals (Gooding et al, 2006). This is in accordance with the results of this study, which showed that by employing sublethal endpoints (growth, movement), it is possible to detect significant effects at concentrations around one-half of the lethal endpoints, which are indicated by the cessation of juvenile ciliary activity.…”

supporting

confidence: 93%

Effects of nitrate nitrogen pollution on Central European unionid bivalves revealed by distributional data and acute toxicity testing

Douda

2009

Aquatic Conservation

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ABSTRACT1. Studies from Central Europe have shown a relationship between the impaired population status of threatened freshwater mussel species and elevated nitrate nitrogen (N-NO À 3 ) concentrations in running waters. 2. Causal mechanisms, however, remain unknown, and no experimental data or comprehensive studies involving more species are available, which causes uncertainty in prioritizing conservation actions.3. This study uses both descriptive and experimental approaches to identify the effects of nitrates on freshwater mussels and demonstrates the need for integrating different research methods for development of conservation strategies for threatened species.4. Spatial co-occurrence of five native freshwater mussel species (Anodonta anatina, Pseudanodonta complanata, Unio pictorum, Unio tumidus, Unio crassus) and N-NO À 3 concentrations were examined in a 7th-order river catchment (Luzˇnice River, Czech Republic) with anthropogenically-induced increasing N-NO À 3 levels and declining populations of these species during the 20th century.5. Acute toxicity of N-NO À 3 was then estimated for artificially reared juveniles of A. anatina and U. crassus using both lethal and sublethal test endpoints.6. Results showed that the probability of occurrence of all species was significantly reduced in reaches with elevated N-NO À 3 levels. 7. In contrast, the results of toxicity testing revealed that the juvenile stages of the two tested species were less sensitive to N-NO À 3 than most previously tested freshwater macroinvertebrates. The detected 96-h median lethal N-NO À 3 concentrations were two orders of magnitude higher than the limits derived from distributional data. 8. Despite the probable absence of a direct negative effect of N-NO À 3 on freshwater mussel populations, N-NO À 3 has potential to be used as an effective indicator of biotope conditions. Identification of causal mechanisms responsible for the observed relationship between unionids and N-NO À 3 will require further research.

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confidence: 93%

Effects of nitrate nitrogen pollution on Central European unionid bivalves revealed by distributional data and acute toxicity testing

Douda

2009

Aquatic Conservation

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“…Some studies have shown that SMCs are widely distributed in aquatic and marine environments [5,6]. Recent studies reported that these compounds have ecotoxic and endocrine-disrupting effects in laboratory animals [7][8][9]. In particular, musk ketone amplifies the genotoxicity of benzo [a]pyrene in humans and increases human susceptibility to the health hazards of benzo [a]pyrene and other PAHs [10].…”

Section: Introductionmentioning

confidence: 98%

“…Lack of species-and sexdependent differences in the concentrations of PAHs and SMCs were found. Naphthalene and 1, 3,4,6,7,6,6,7,8, were predominant compounds in all the samples for PAHs and SMCs, respectively. The concentrations of PAHs and SMCs were significantly correlated with each other, but were not correlated with body size of cetaceans.…”

mentioning

confidence: 97%

Accumulation of PAHs and synthetic musk compound in minke whales (Balanoptera acutorostrata) and long‐beaked common dolphins (Delphinus capensis) from Korean coastal waters

Moon

An²,

Choi³

et al. 2012

Enviro Toxic and Chemistry

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Information on the occurrence and accumulation profiles of polycyclic aromatic hydrocarbons (PAHs) and synthetic musk compounds (SMCs) in marine mammals is scarce. In the present study, we recorded the concentrations and profiles of PAHs and SMCs in liver tissue and blubber from minke whales and common dolphins from Korean coastal waters. The overall concentrations of PAHs and SMCs in blubber from both cetacean species were approximately three to five times higher than those in liver tissues. Residue levels of PAHs were lower, whereas levels of SMCs were relatively higher than those reported in other studies. Lack of species- and sex-dependent differences in the concentrations of PAHs and SMCs were found. Naphthalene and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-r-2-benzopyran (HHCB) were predominant compounds in all the samples for PAHs and SMCs, respectively. The concentrations of PAHs and SMCs were significantly correlated with each other, but were not correlated with body size of cetaceans. The present data provide valuable information on the exposure of Korean cetaceans to PAHs and SMCs.

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“…Whether Tonalide and Pearlide have harmful effects remains to be investigated in animal experiments, as they have been reported to be toxic (9)(10)(11). Tonalide is not expected to be very harmful at low doses due to its prolonging effect in tumor-transplanted mice.…”

Section: Discussionmentioning

confidence: 99%

“…We studied the carcinostatic activity of diverse aromatics in a series screening anticancer agents (4,5) and found Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyltetrahydronaphthalene, AHTN), an aromatic widely used in some detergents or soaps, to have carcinostatic activities. The antitumor effects of tonalide remain to be elucidated, whereas its toxicity has been reported in environmental (6)(7)(8) and biological (9)(10)(11) studies.…”

Section: Introductionmentioning

confidence: 99%

The antitumor activities of the structurally-similar two-species aromatics Tonalide and Pearlide and the enhancement of their effects by hyperthermia

Asada

Kageyama²,

Tanaka³

et al. 2008

Mol Med Rep

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Abstract. Antitumor activities have been reported for the aromatics Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyl-tetrahydronaphthalene, AHTN) and Pearlide (1,3,4,6,7,6,6,7,8, HHCB), which are contained in detergents. In this study, their carcinostatic activities in Ehrlich ascites tumor (EAT) cells were evaluated by mitochondrial dehydroganase-based WST-1 assay and dye-exclusion assay. The viability of EAT cells treated at 37 or 42˚C for 30 min and sequentially cultured at 37˚C was assayed at graded times. Immediately after treatment at 37˚C, neither Tonalide nor Pearlide had an effect on EAT cells, even at a concentration as high as 200 μM. However, cell viability was reduced to 40% versus the control after 20 h of culture with Tonalide at 50 μM, and to below 20% at 25 μM after 72 h. In contrast, Pearlide was nearly inactive, even at a dose of 100 μM after 20 h of culture, and only reduced cell viability to 41.2% after 72 h. After treatment at 42˚C without culture, neither of the aromatics was effective, even at a dose of 200 μM. The viability of cells cultured with Tonalide for 20 h after treatment at 42˚C was reduced to nearly half of that at 37˚C, and to 10% of the control after culture for 72 h. These values for the reduction of cell viability were also acheived by the Trypan blue dye-exclusion assay. The lifespan-prolonging effects of Tonalide on mice implanted with EAT cells were also examined. The lifespan of mice administrated 1.8 mg/day of Tonalide was prolonged by up to 28 days, while mice that did not receive Tonalide died within a mean of 15 days. Thus, Tonalide exhibited marked carcinostatic effects in vitro and in vivo and may prove to be a potent multipurpose antitumor agent in combination with hyperthermia.

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Toxicity of Synthetic Musks to Early Life Stages of the Freshwater Mussel Lampsilis cardium

Cited by 62 publications

References 26 publications

Effects of nitrate nitrogen pollution on Central European unionid bivalves revealed by distributional data and acute toxicity testing

Effects of nitrate nitrogen pollution on Central European unionid bivalves revealed by distributional data and acute toxicity testing

Accumulation of PAHs and synthetic musk compound in minke whales (Balanoptera acutorostrata) and long‐beaked common dolphins (Delphinus capensis) from Korean coastal waters

The antitumor activities of the structurally-similar two-species aromatics Tonalide and Pearlide and the enhancement of their effects by hyperthermia

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