Toxicity of Tannic Acid

Barnes, James E.

doi:10.1016/s0140-6736(00)87196-2

Cited by 27 publications

(8 citation statements)

References 9 publications

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“…30 , 33 , 34 However, concerns of its safety were raised when autopsies done on 14 soldiers treated with TA for burns showed liver necrosis and polymorphonuclear infiltration. 35 Additional causes of liver necrosis observed in the soldiers were not ruled out, such as untreated sepsis, hypovalemic shock state, or reabsorption of lipid protein complexes from burnt skin. 30 , 35 Subsequent mice studies showed that high concentrations of TA injected subcutaneously (>75 g/kg body weight) or intravenously (>40 g/kg body weight) were able to cause death in some cases, though the exact cause of death was not reported.…”

Section: Discussionmentioning

confidence: 99%

“…35 Additional causes of liver necrosis observed in the soldiers were not ruled out, such as untreated sepsis, hypovalemic shock state, or reabsorption of lipid protein complexes from burnt skin. 30 , 35 Subsequent mice studies showed that high concentrations of TA injected subcutaneously (>75 g/kg body weight) or intravenously (>40 g/kg body weight) were able to cause death in some cases, though the exact cause of death was not reported. 36 In the same studies, smaller dosages of TA showed no visible pathology.…”

Section: Discussionmentioning

confidence: 99%

“…36 In the same studies, smaller dosages of TA showed no visible pathology. 35 , 36 Liver damage was measured with bromsulphalein dye retention after 10 g/kg body weight TA dosage administered subcutaneously, showed as much as 30% retention of TA. 35 , 36 However, topically applied TA had no observed effect.…”

Section: Discussionmentioning

confidence: 99%

“…35 , 36 Liver damage was measured with bromsulphalein dye retention after 10 g/kg body weight TA dosage administered subcutaneously, showed as much as 30% retention of TA. 35 , 36 However, topically applied TA had no observed effect. Later studies found that a 3% TA treatment topically applied to experimental burns showed less liver structure changes in animals treated with TA for burns compared to untreated.…”

Section: Discussionmentioning

confidence: 99%

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The in vivo biocompatibility of novel tannic acid-collagen type I injectable bead scaffold material for breast reconstruction post-lumpectomy

Baldwin

Frank-Kamenetskii

et al. 2020

J Biomater Appl

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Breast cancer is the most common invasive cancer in women worldwide. Surgical removal of the breast tumor and subsequent reconstructive surgery can result in complications such as infection or necrosis of transplanted adipose tissue. Breast cancer recurrence is also a serious concern for patients. Our group has developed a tannic acid/collagen bead material that has the potential to be used as an injectable adipose tissue regenerative device to replace lipofilling. Tannic acid is a polyphenol with anticancer and antibiotic properties. The objective of this study was to establish the biocompatibility of an injectable tannic acid/collagen bead implant material in an in vivo rat model. The injection of the tannic acid-collagen type I bead device was minimally invasive. No symptoms of infection, tissue necrosis, or widespread chronic inflammation were observed. After 12 weeks, implants showed incorporation into native tissue with no fibrous encapsulation. Despite the presence of inflammatory cells in the remaining beads, fat tissue growth and collagen redistribution were observed within the beads over 12 weeks, showing incorporation within native subcutaneous tissue and indicating good biocompatibility and bioactivity of the implant. Our results demonstrate that the tannic acid/collagen bead scaffold has good biocompatibility and works as an adipocyte tissue regeneration and reconstructive device.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The in vivo biocompatibility of novel tannic acid-collagen type I injectable bead scaffold material for breast reconstruction post-lumpectomy

Baldwin

Frank-Kamenetskii

et al. 2020

J Biomater Appl

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“…On sait cependant que l'injec tion intraveineuse de tannate de sodium (11) entraîne rapidement la mort, l'autopsie révélant une nécrose du foie. D'autre part, le tannate de sodium, administré par voie intramusculaire est plus toxique que l'acide tannique, mais les dommages hépatiques ne sont visibles que lors d'injections intraveineuses (2).…”

Section: Introductionunclassified

Etude comparée des effets de l’acide tannique et de l’acide tannique oxydé sur la croissance, la composition corporelle et l’utilisation biologique des aliments chez le rat

1978

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The nutritional effects of oxidized tannic acid in rats have been compared with the effects of tannic acid supplemented or not with a reductor: sodium sulfite. The results indicate that in the group which ingested oxidized tannic acid, fecal nitrogen excretion is lower than in the group which ingested tannic acid; its action on growth is mainly exerted by reduction of the retention coefficient; urinary nitrogen excretion being increased. With regard to the other groups of animals, oxidized tannic acid decreases the weight gain of the thymus and slightly increases the weight gain of the heart. Sulfite supplementation does not change the effects of tannic acid on growth; nevertheless, a higher weight gain of the kidneys is noted.

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Diseases of the Liver and Biliary Tract

Greene¹

1944

Arch Intern Med (Chic)

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Toxicity of Tannic Acid

Cited by 27 publications

References 9 publications

The in vivo biocompatibility of novel tannic acid-collagen type I injectable bead scaffold material for breast reconstruction post-lumpectomy

The in vivo biocompatibility of novel tannic acid-collagen type I injectable bead scaffold material for breast reconstruction post-lumpectomy

Etude comparée des effets de l’acide tannique et de l’acide tannique oxydé sur la croissance, la composition corporelle et l’utilisation biologique des aliments chez le rat

Diseases of the Liver and Biliary Tract

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