2014
DOI: 10.1016/j.toxlet.2014.03.023
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Toxicity of TDCPP and TCEP on PC12 cell: Changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels

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Cited by 116 publications
(68 citation statements)
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“…Likewise, a recent study reported that TDCIPP can (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) induce apoptotic cell death in PC12 cells (Ta et al, 2014). Taken together, these findings suggested that induction of apoptosis may be one of the mechanisms of TDCIPP-induced neurotoxicity.…”
Section: Discussionmentioning
confidence: 61%
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“…Likewise, a recent study reported that TDCIPP can (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) induce apoptotic cell death in PC12 cells (Ta et al, 2014). Taken together, these findings suggested that induction of apoptosis may be one of the mechanisms of TDCIPP-induced neurotoxicity.…”
Section: Discussionmentioning
confidence: 61%
“…Although TDCIPP has been proposed to be a neurotoxicant (Wang et al, 2015a,b;Ta et al, 2014), its toxicity, and in particular the mechanisms of its toxicity, are not well understood. In the present study, we demonstrated that TDCIPP can induce apoptosis and also autophagy in SH-SY5Y cells through induction of ROS.…”
Section: Discussionmentioning
confidence: 99%
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“…A recent DNA microarray study in chicken embryos injected with TDCPP demonstrated toxicity to lipid metabolism, including cholesterol, as well as a transcriptional dysregulation of genes involved in immune response (Farhat et al, 2014). In vitro studies show that TDCPP exhibits similar neurotoxic actions to organophosphorus (OP) pesticides (e.g., altered neurodifferentiation) (Dishaw et al, 2011) and exerts cytotoxic and neurotoxic effects to PC12 cells (e.g., decreased cell growth, increased apoptosis, altered cell morphology, and changes in gene expression) (Ta et al, 2014). However, knowledge of the toxicological and environmental health effects of TDCPP remains limited, particularly the effects of long-term exposures to low concentrations and whether TDCPP causes neurotoxicity in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…Published data suggest that exposure to TDCIPP causes various toxicities depending on organisms tested, such as endocrine disruption (Kojima et al, 2013;Liu et al, 2013;Zhang et al, 2014;Wang et al, 2015a), neural toxicity (Dishaw et al, 2011(Dishaw et al, , 2014Ta et al, 2014;Wang et al, 2015bWang et al, , 2015c, hepatoxicology (Crump et al, 2012;Farhat et al, 2013Farhat et al, , 2014aFarhat et al, , 2014bLiu et al, 2016) and developmental and reproductive toxicity (Liu et al, 2012;Liu et al, 2013;McGee et al, 2012;Farhat et al, 2013;Fu et al, 2013;Wang et al, 2015a). For example, acute exposure to TDCIPP affects embryonic development by delaying remethylation of the zygotic genome and embryonic epiboly and results in significantly greater mortality in embryos of zebrafish (McGee et al, 2012;Fu et al, 2013).…”
mentioning
confidence: 99%