“…Published data suggest that exposure to TDCIPP causes various toxicities depending on organisms tested, such as endocrine disruption (Kojima et al, 2013;Liu et al, 2013;Zhang et al, 2014;Wang et al, 2015a), neural toxicity (Dishaw et al, 2011(Dishaw et al, , 2014Ta et al, 2014;Wang et al, 2015bWang et al, , 2015c, hepatoxicology (Crump et al, 2012;Farhat et al, 2013Farhat et al, , 2014aFarhat et al, , 2014bLiu et al, 2016) and developmental and reproductive toxicity (Liu et al, 2012;Liu et al, 2013;McGee et al, 2012;Farhat et al, 2013;Fu et al, 2013;Wang et al, 2015a). For example, acute exposure to TDCIPP affects embryonic development by delaying remethylation of the zygotic genome and embryonic epiboly and results in significantly greater mortality in embryos of zebrafish (McGee et al, 2012;Fu et al, 2013).…”