2019
DOI: 10.3390/nano9070968
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Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

Abstract: Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO2, ZnO, SiO2, and coated SiO2 nanoparticles, and evaluate their suitability as additives to consolidants of weathered construction materials. First, water soluble tetrazolium 1 (WST-1) and lactate dehydrogenase (LDH) assays were used t… Show more

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Cited by 39 publications
(37 citation statements)
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“…Concerning the preparation of consolidants, five commercially available metal oxide nanoparticles were used, including Aeroxide ® TiO 2 P25 (Evonik Industries, Essen, Germany), Aerosil ® SiO 2 200 Pharma, Aerosil ® SiO 2 R805, Aerosil ® SiO 2 R9200 (all Evonik Industries, Essen, Germany) and NanoZnO (Bochemie, Bohumin, Czech Republic). Detailed characteristics of the nanoparticles are provided in reference [11]. Dynasylan 40 was obtained from Evonik Industries (Essen, Germany), isopropanol (IPA), dibutyltin dilaurate (DBTL), n-octylamine, were all from Sigma-Aldrich (St. Louis, MO, USA), and Ca(OH) 2 (Penta, Prague, Czech Republic).…”
Section: Methodsmentioning
confidence: 99%
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“…Concerning the preparation of consolidants, five commercially available metal oxide nanoparticles were used, including Aeroxide ® TiO 2 P25 (Evonik Industries, Essen, Germany), Aerosil ® SiO 2 200 Pharma, Aerosil ® SiO 2 R805, Aerosil ® SiO 2 R9200 (all Evonik Industries, Essen, Germany) and NanoZnO (Bochemie, Bohumin, Czech Republic). Detailed characteristics of the nanoparticles are provided in reference [11]. Dynasylan 40 was obtained from Evonik Industries (Essen, Germany), isopropanol (IPA), dibutyltin dilaurate (DBTL), n-octylamine, were all from Sigma-Aldrich (St. Louis, MO, USA), and Ca(OH) 2 (Penta, Prague, Czech Republic).…”
Section: Methodsmentioning
confidence: 99%
“…Another strategy involves the incorporation of elastic segments, such as hydroxyl-terminated polydimethylsiloxane (PDMS), into the xerogel structure; these segments effectively removed the stress caused by capillary pressure [5][6][7][8][9]. Another more general approach is based on the incorporation of various oxide nanoparticles, such as SiO 2 , TiO 2 , Al 2 O 3 and ZnO (so-called particle-modified consolidants, PMC) [3,8,[10][11][12][13][14][15]. Due to the increase in the pore size of PMC-based xerogel and the improvement of its mechanical properties, cracking was reduced, and the consolidation effect enhanced.…”
Section: Introductionmentioning
confidence: 99%
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“…Moreover, the anti-bacterial potential of Zinc oxide nanoparticles was observed to be effective than that of Zinc oxide, essentially classified due to the smaller particles comprising a superior surface-dependent to amount of volume, which exhibits significant anti-bacterial properties [15]. ZnNPs also had substantial toxicity against cancer cells as discovered by various researchers [16,17]. ZnNPs are also considered to be top photocatalysts, which are employed in sanitizing wastewater, and decay or reduce herbicides and pesticides [1].…”
Section: Introductionmentioning
confidence: 98%