Toxicity of toxaphene in the rat and beagle dog

Chu, Ih; Villeneuve, D. C.; Sun, Chong-Wu; Secours, V. E.; Procter, B. G.; Arnold, Elsie; Clegg, D. J.; Reynolds, L. M.; Valli, V. E.

doi:10.1016/0272-0590(86)90090-4

Cited by 19 publications

(4 citation statements)

References 7 publications

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“…Therefore, it is not possible to assign the observed induction of this formation rate in the highest dose group to a specific P450 enzyme. Based on the combination of earlier studies [12–14,31–33] and our present study, it can be suggested that the induction pattern of toxaphene does not fully resemble that of phenobarbital.…”

Section: Discussionsupporting

confidence: 67%

“…The reported environmental levels in biota are much lower than the hepatic residue levels in our study or the concentration in the feed [14] that caused effects on P450 activities in rats and Japanese quail. Based on the present results, we conclude that induction of P450 activities in the liver of rats and Japanese quail is unlikely to occur at environmentally relevant exposure levels.…”

Section: Discussionmentioning

confidence: 56%

“…The relatively low susceptibility of rats toward P450 activity induction by toxaphene is in concordance with earlier studies. Only in the highest dose groups of male (45.9 mg/kg body wt/d) and female rats (63 mg toxaphene/kg body wt/d) that were fed toxaphene‐contam‐inated feed for 13 weeks were P450 activities induced [14]. No effects were observed in the second highest dose groups (8.6 mg of toxaphene/kg body wt/d for the males, 12.6 mg of toxaphene/kg body wt/d for the females).…”

Section: Discussionmentioning

confidence: 99%

“…dose (165 mg/kg body wt) of technical toxaphene [12]. Induction of P450 activities in male and female rats exposed to toxaphene in the feed were also reported [13,14]. These studies indicate that P450 activities could be induced by toxaphene, but no dose‐effect relationship was established.…”

Section: Introductionmentioning

confidence: 99%

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Induction of hepatic cytochrome p450 activities by toxaphene in rat and japanese quail

Drenth

Oevelen

Buitenhuis

et al. 2000

Enviro Toxic and Chemistry

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Several organochlorine compounds can induce hepatic cytochrome P450 activities. We exposed female Japanese quail and female rats to a single oral dose of technical toxaphene ranging from 0.012 to 40 mg/kg body weight to investigate a possible dose‐response relationship for P450 activity induction. The hepatic microsomal alkoxyresorufin dealkylation and steroid hydrox‐ylation activities (testosterone, 17β‐estradiol) were determined. Only in the highest dose groups (40 mg/kg) of rats and Japanese quail were some P450 activities induced. Pentoxyresorufin‐O‐dealkylation, formation of 15β‐hydroxytestosterone, and formation of 2‐hydroxyestradiol were induced significantly (p ≤ 0.05) in rat hepatic microsomes with a factor of 3.9, 3.1, and 2.4, respectively. In Japanese quail hepatic microsomes, the formation rates of 6β‐, 15α‐, 16β‐hydroxytestosterone and androstenedione were induced significantly (p ≤ 0.05) with a factor of 2.4, 6.5, 3.3, and 1.6, respectively. It is concluded that exposure to toxaphene can lead to specific P450 activity induction in rats and Japanese quail but only at doses near reported LD50 values. Because reported toxaphene levels in biota are lower compared with liver residue levels that we have measured in our study, we conclude that it is unlikely that P450 activity induction occurs in wildlife higher in the food chain due to environmental toxaphene exposure.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Induction of hepatic cytochrome p450 activities by toxaphene in rat and japanese quail

Drenth

Oevelen

Buitenhuis

et al. 2000

Enviro Toxic and Chemistry

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Chloriertes Camphen (Toxaphen) [MAK Value Documentation in German language, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 27. Lieferung, Ausgabe 1998 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Toxaphene [MAK Value Documentation, 2003]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 19 (2003) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Absorption, distribution, elimination Metabolism Effects in Man Animal Experiments and in vitro Studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Reproductive and developmental toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value/classification)

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Toxicity of toxaphene in the rat and beagle dog

Cited by 19 publications

References 7 publications

Induction of hepatic cytochrome p450 activities by toxaphene in rat and japanese quail

Induction of hepatic cytochrome p450 activities by toxaphene in rat and japanese quail

Chloriertes Camphen (Toxaphen) [MAK Value Documentation in German language, 1998]

Toxaphene [MAK Value Documentation, 2003]

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