Toxicity of Withania Somnifera Root Extract in Rats and Mice

Sharada, A.C.; Solomon, F. Emerson; Devi, P. Uma

doi:10.3109/13880209309082943

Cited by 51 publications

(23 citation statements)

References 9 publications

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“…This is of significance, as the root powder of the plant is used in the crude form in the Indian system of medicine (1). Moreover, the crude extract ( 100 mg/kg x 30) was well tolerated and has an anabolic effect on mice, as evident from the increase in blood hemoglobin levels and body weight (12). It can be concluded from the present study that withaferin A is effective in inhibiting the growth of Ehrlich ascites tumor in mouse.…”

Section: Discussionmentioning

confidence: 51%

Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo

et al. 1996

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Section: Discussionmentioning

confidence: 51%

Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo

et al. 1996

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“…administration of an ethanol extract of Ashwagandha, LD 50 was 1259 mg/kg in mice. 49) Although withanolide A, withanoside IV, and withanoside VI showed neurite outgrowth activity at 1 µM, withaferin A and withanolide D (Fig. 1) showed neurotoxicity at 1 µM in cultured SH-SY5Y cells 18,19) and normal cortical neurons.…”

Section: Safety Of Ashwagandha and Its Con-stituentsmentioning

confidence: 99%

Effects of Ashwagandha (Roots of <i>Withania somnifera</i>) on Neurodegenerative Diseases

Kuboyama

Tohda

Komatsu

2014

Biological & Pharmaceutical Bulletin

121

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Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera DUNAL) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

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“…As of today, no herb-herb or herb-drug interactions has been reported in the literature with W. somnifera (Kulkarni and Dhir, 2008;Prabu et al, 2013;Sharada et al, 1993). The side effects and the long-term safety of W. somnifera are still under construction.…”

Section: Introductionmentioning

confidence: 99%

Chemistry and pharmacology of withania somnifera: An update

Kumar¹,

Dey²,

Hadimani³

et al. 2015

TANG [HUMANITAS MEDICINE]

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Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it is used as tonic to rejuvenate the body and increase longevity. In Ayurvedic preparations, various parts of the plant have been used to treat variety of ailments that affect the human health. However, dried roots of the plant are widely used for the treatment of nervous and sexual disorders. The major active chemical constituents of this plant are withanolides, which is responsible for its wide range of biological activities. Since the beginning of the 20 th century, a significant amount of research has been done and efforts are ongoing to further explore other bioactive constituents, and many pharmacological studies have been carried out to describe their disease preventing mechanisms. In this chapter, we have reviewed the chemistry and pharmacological basis of W. somnifera in various human ailments.

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Toxicity of Withania Somnifera Root Extract in Rats and Mice

Cited by 51 publications

References 9 publications

Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo

Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo

Effects of Ashwagandha (Roots of <i>Withania somnifera</i>) on Neurodegenerative Diseases

Chemistry and pharmacology of withania somnifera: An update

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