Toxicity Profile of Karuho Poison on the Brain of Wistar Albino Rats

Kyolo, Samuel Kule; Bbosa, Godfrey S.; Odda, John; Lubega, Aloysius; Edmond, Ntabe Namegabe

doi:10.4236/nm.2018.92008

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…Any foreigner traveling to the east of the country, mainly, to Goma and Bukavu, had to develop the unusual symptoms attributed to this unknown mythical poison. The patients were cared for only by traditional healers and self-proclaimed toxicologists, presenting themselves as the only specialists in this poison, since this phenomenon was unknown in the hospital [7][8][9].…”

Section: Background 21 Research Designmentioning

confidence: 99%

Atmospheric Pollution and Toxicological Aspects of Helicobacter pylori Infection: Background, Pathophysiology and New Innovative Hypotheses

Ndelo di Phanzu,

Mputu Malolo,

Ndelo Matondo

et al. 2024

Gastric Cancer - Progress and Challenges in the Era of Precision Medicine

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A strange phenomenon characterized by numerous pathologies occurred in DR Congo and in some other countries of Subsaharian Africa since a few decades. While the entire population is convinced of massive poisonings provoked by a ritual poison from the eastern Africa, named Karuho, we incredibly established, since 2010, the responsibility of Helicobacter pylori in the phenomenon, thanks to cross-sectional epidemiological studies. Our findings have been published in international journals and presented in international scientific forums. The purpose of this chapter is to describe the background and conduct of this research, the pathophysiology of the Helicobacter pylori involvement, as well as the new innovative hypotheses on Helicobacter infection generated by this research.

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Section: Background 21 Research Designmentioning

confidence: 99%

Atmospheric Pollution and Toxicological Aspects of Helicobacter pylori Infection: Background, Pathophysiology and New Innovative Hypotheses

Ndelo di Phanzu,

Mputu Malolo,

Ndelo Matondo

et al. 2024

Gastric Cancer - Progress and Challenges in the Era of Precision Medicine

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“…The OMGKRP Karuho poison was selected based on its potency or activity using the previous study findings during the screening study that was conducted to determine the toxicity profile of the different Karuho poisons and their effects on the brain of Wistar rats [23].…”

Section: Selection Criteria Of Omgkrp Karuho Poisonmentioning

confidence: 99%

“…Four samples of OMGKRP were purchased from a well-known traditional healer who provided the same sample for previous study [23] and who prepared it using the same ingredients. However, the healer kept secret, the ingredients used in the preparation of the OMGKRP poison.…”

Section: Purchasing and Handling Of Omgkrp Karuho Poison Samplesmentioning

confidence: 99%

“…Liver and Heart Tissues Three dose levels including 1, 5 and 20 mg/Kg bwt were selected from acute toxicity study carried out in previous study [23] and were administered daily to the rats for 28-days according to OECD 407 methods [28] using the intra-gastric tube directly into the stomach. Unexceptional dose of 5000 mg/Kg was used as fourth dose as a way to compare its toxic effects to that of the lowest dose that is commonly used by unscrupulous individuals.…”

Section: Determination Of Sub-acute Effect Of Omgkrp On Kidney Lungmentioning

confidence: 99%

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Blood Chemistry and Major Body Organ Induced-Toxicity by Locally-Made Traditional OMGKRP Karuho Poison in Wistar Albino Rats

Kyolo¹,

Odda²,

Lubega³

et al. 2019

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OMGKRP is one of various Karuho poison mysteriously used by unscrupulous individuals to kill people during conflict and animals in Goma City, in DRC. The symptoms and signs of most cases are usually confused with many chronic diseases like tuberculosis and HIV/AIDS; with renal, hepatic and cardiac manifestations as well as blood chemistry changes. The study investigated the toxic effect of OMGKRP poison on blood chemistry, serum enzymes and organ toxicity including the kidney, lung, liver and heart of Wistar albino rats. A laboratory-based experimental study was conducted. Fifty animals in 5 groups each with 10 animals were dosed daily for 28 days with 1.0 mg, 5.0 mg, 20.0 mg and 5000.0 mg/Kg body weight of OMGKRP and normal saline as control group. International standard guidelines, OECD 407 and NIH 2011 were followed during the study period. The blood chemistry analysis, relative organ weight and histopathological changes in the kidney, lung, liver and heart were performed. The findings showed that OMGKRP was associated with increased blood chemistry parameters including total proteins, creatinine, urea, K + levels, direct albumin levels, a decrease in Cl − levels and albumin levels. Histopathological findings showed an increased relative weight and tissue damages of the lung, kidney, liver and heart. Therefore, OMGKRP Karuho poison caused toxicity on blood chemistry, serum enzymes as well as histopathological changes in the lung, renal, hepatic and cardiac tissue damages in Wistar albino rats.

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Toxicity Profile of Karuho Poison on the Brain of Wistar Albino Rats

Cited by 2 publications

References 18 publications

Atmospheric Pollution and Toxicological Aspects of Helicobacter pylori Infection: Background, Pathophysiology and New Innovative Hypotheses

Atmospheric Pollution and Toxicological Aspects of Helicobacter pylori Infection: Background, Pathophysiology and New Innovative Hypotheses

Blood Chemistry and Major Body Organ Induced-Toxicity by Locally-Made Traditional OMGKRP Karuho Poison in Wistar Albino Rats

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