Toxicity related to autologous peripheral blood haematopoietic progenitor cell infusion is associated with number of granulocytes in graft, gender and diagnosis of multiple myeloma

Abstract

Our results indicate that beside the infused DMSO dose, the composition of graft as well as patient's diagnosis are also very important factors for infusion-related toxicity.

Limiting the Daily Total Nucleated Cell Dose of Cryopreserved Peripheral Blood Stem Cell Products for Autologous Transplantation Improves Infusion-Related Safety with No Adverse Impact on Hematopoietic Engraftment

“…It is possible that factors predisposing to poor mobilization and/or correlating with pre-transplant co-morbidity profiles, especially cardiovascular disease or infections might also predispose a patient to more severe infusion-related toxicity. Age, gender and patient diagnosis have been reported as predictors of AEs in other studies (4, 8, 17). Bojanic et al identified female gender and diagnosis of multiple myeloma in addition to granulocyte content as factors predicting infusion-related toxicity(4).…”

“…Age, gender and patient diagnosis have been reported as predictors of AEs in other studies (4, 8, 17). Bojanic et al identified female gender and diagnosis of multiple myeloma in addition to granulocyte content as factors predicting infusion-related toxicity(4). The effect of age is not so clear as Milone et al reported increasing incidence of AEs with increasing age(8) whereas Cordoba et al found increased age to be protective against occurrence of AEs(17).…”

“…The overall incidence of all adverse events associated with autologous PBSC infusions reported in the literature ranges from 13.5 to 67.3%(4, 8, 16, 17). More severe infusion-related events occur in the range of 0.4%, as reported by Graves et al(26).…”

“…At the time of collection, obtaining high quality apheresis products with minimal contamination by mature myeloid cells is desirable (4, 8, 16, 17). Poor mobilization of CD34+ progenitor cells is a major factor that can negatively affect the quality of the apheresis product.…”

Use of various offset settings in the Fenwal Amicus during hematopoietic progenitor cell collection to increase lymphocyte yield and reduce cross‐cellular contamination

“…In addition, Milone et al reported noncardiovascular AEs were dependant on patient age and the concentration of nonmononuclear white blood cells in the infused HPC product [2]. Bojanic et al reported toxicity of autologous HPC infusions was associated with the number of granulocytes in the graft, gender, and diagnosis of multiple myeloma [3]. The only cells that survive the freezing process are MNC; so cellular debris from ruptured RBC, PLT, and granulocytes are infused into the patient.…”