Toxicity studies in fertilized zebrafish eggs treated with N-methylamine, N,N-dimethylamine, 2-aminoethanol, isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol

Groth, Georg; Schreeb, K H; Herdt, Veerle De; Freundt, K. J.

doi:10.1007/bf00209953

Cited by 31 publications

(10 citation statements)

References 4 publications

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“…Treatment effects included delayed hatching and developmental toxicity (Zhu and Shi, ). Organic pesticides, such as astrazine, malathion, carbaryl, urea, and lindane have been tested and the LC 50 values were reported (Dave, ; Gorge and Napel, ; Dave and Xiu, ; Groth et al, ; Schulte and Nagel, ; Zhu and Shi, ). The LC 50 of 40 organic‐solvent reagents were assessed after incubating for 48 or 96 hr (Zhu and Shi, ).…”

Section: Toxicological Studiesmentioning

confidence: 99%

Zebrafish: An Animal Model for Toxicological Studies

2003

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Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening.

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Section: Toxicological Studiesmentioning

confidence: 99%

Zebrafish: An Animal Model for Toxicological Studies

2003

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“…Previous studies have examined the acute toxicity of various pesticide chemicals to eggs and early-life-stage development (Elonen et al, 1998;Gallo et al, 1995;Groth et al, 1993;Henry et al, 1997;Samson and Shenker, 2000;Westerlund et al, 2000;Wiegand et al, 2000). The research reported here focuses speci"cally on egg development under exposure to Sevin.…”

Section: Introductionmentioning

confidence: 98%

Effects of Sevin (Carbaryl Insecticide) on Early Life Stages of Zebrafish (Danio rerio)

Todd

Leeuwen

2002

Ecotoxicology and Environmental Safety

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“…Accordingly, these compounds are discharged into the environment and they are considered priority pollutants in environmental risk assessment (Okamura et al, 1996). There are to date, therefore, many reports from studies of the effects of aniline and chlorinated anilines on aquatic organisms, including the calculation of half-maximal (50%) effective concentration (EC 50 ), lethal concentration, 50% (LC 50 ), and no-observed-effect concentration (Groth et al, 1993;Leeuwen et al, 1990;Scheil et al, 2009). However, sublethal effects of these chemicals, including edema, body curvature and absence of swim-bladder inflation, are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Lethal and sublethal effects of aniline and chlorinated anilines on zebrafish embryos and larvae

Horie

Yamagishi

Koshio

et al. 2017

J of Applied Toxicology

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Environmental risk assessments show increased attention to the sublethal effects of chemicals on aquatic organisms. The Organization for Economic Cooperation and Development (OECD) established the "Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages" (OECD test 212) to predict lethal effects. It is still unclear, however, whether this test can predict sublethal effects. Although their sublethal effects are still unknown, chlorinated anilines are widely used in various fields. The purpose of this study, therefore, is to investigate sublethal effects of chlorinated anilines using OECD test 212 with zebrafish, and to examine the correlation of several sublethal effects between embryo and larval stages. Embryos were exposed to aniline and nine chlorinated anilines until 8 days post-fertilization. A delayed lethal effect was observed from three of the 10 anilines tested. In the control group, the swim bladder inflated after hatching, but there was no swim-bladder inflation after exposure to the chlorinated anilines. Fertilized eggs exposed to lower concentrations of test chemicals showed effects during embryogenesis that did not affect mortality rates, such as changes in body curvature and edema. Our results show that chlorinated anilines induce not only lethal effects but also a variety of sublethal effects. Moreover, a detailed estimate of these effects requires study during both embryonic and larval stages. OECD test 212 may therefore prove useful as a method for screening chemicals for lethal and sublethal effects. Copyright © 2017 John Wiley & Sons, Ltd.

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Toxicity studies in fertilized zebrafish eggs treated with N-methylamine, N,N-dimethylamine, 2-aminoethanol, isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol

Cited by 31 publications

References 4 publications

Zebrafish: An Animal Model for Toxicological Studies

Zebrafish: An Animal Model for Toxicological Studies

Effects of Sevin (Carbaryl Insecticide) on Early Life Stages of Zebrafish (Danio rerio)

Lethal and sublethal effects of aniline and chlorinated anilines on zebrafish embryos and larvae

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