Toxicity Studies of Certain Organic Peroxides and Hydroperoxides

Floyd, Emily; Stokinger, Herbert E.

doi:10.1080/00028895809343577

Cited by 40 publications

(9 citation statements)

References 7 publications

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“…The results with diaminohexane are in contradiction to Soviet claims (Kulakov, 1967) Floyd and Stokinger (1958), who found the LC50 (4 hours) to be 220 ppm in rats. Soviet claims (Solomin, 1964(Solomin, , 1966 suggest that the concentration of this compound must be reduced to 0-001 ppm to avoid effects on animals and on man.…”

Section: Presentation Of Experimental Resultscontrasting

confidence: 55%

The Subacute Inhalation Toxicity of 109 Industrial Chemicals

Gage¹

1971

Journal of Occupational and Environmental Medicine

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Section: Presentation Of Experimental Resultscontrasting

confidence: 55%

The Subacute Inhalation Toxicity of 109 Industrial Chemicals

Gage¹

1971

Journal of Occupational and Environmental Medicine

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“…On the basis of experimental data, lipid peroxidation of target organs due to free radicals liberated from MEKP and toxicity due to the generation of organic acids such as acetic acid, formic acid, and propionic acid as a result of MEKP metabolism seem to be the dominant pathophysiological mechanisms in this intoxication (2,3,9,18). Treatment of rats with 40 mg/kg of MEKP quickly induced lipid peroxidation in vivo, and from one to four hours after treatment caused a depression in the plasma content of vitamin E and the liver content of glutathione, as well as elevations in serum activities of alanine and aspartate aminotransferases (19).…”

Section: Discussionmentioning

confidence: 99%

“…The ability to cause eye irritation in rabbits has been shown to correlate with chemical reactivity. Systemic toxicity studies have shown that MEKP is the most toxic organic peroxide, followed by tert-butyl-hydroperoxide or cumene-hydroperoxide, and di-tert-butyl-peroxide, in that order (1)(2)(3). Commercially, the term MEKP usually designates the technical grade of this material, which is really a solution of a mixture of various methylethyl ketone peroxides and hydroperoxides in dimethylphtalate.…”

Section: Introductionmentioning

confidence: 99%

N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication

Enckevort

Touw

Vleming

2008

Clinical Toxicology

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The plastic hardener methyl ethyl ketone peroxide (MEKP) is an unstable peroxide that releases free oxygen radicals. Ingestion of this compound induces widespread liver necrosis that is often fatal, extensive ulceration with subsequent scarring, and stenosis of the proximal digestive tract in survivors. Severe metabolic acidosis occurs due to the accumulation of formic acid and other organic acids inducing neurologic damage, such as optic nerve lesions. A 53-year-old man unintentionally ingested approximately 120 ml of a 33% solution of this compound in dimethylphtalate. The patient was treated with the free radical scavenger N-acetylcysteine to counteract free radical-mediated damage and with hemodialysis to remove accumulated organic acids. Although our patient demonstrated considerable edema and ulceration of the distal esophagus, stomach and duodenum in the acute phase, there was never any sign of liver damage or neurological damage, nor were there any demonstrable lesions in the proximal digestive tract three weeks after the event. Treatment with a combination of N-acetylcysteine and haemodialysis may be a promising therapy for this severe and potentially life-threatening intoxication.

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“…The investigation of photoformation and transformation of ROOH may provide useful insights into the photoformation of HO • and RO • . Moreover, the oxidation of organic compounds by HO • also leads to ROOH formation, and ROOH usually presents higher toxicity than the original organic compounds. , Therefore, the details of ROOHs, such as quantum yields, steady-state concentrations, and degradation pathways in natural waters under solar irradiation, should be investigated.…”

Section: Introductionmentioning

confidence: 99%

Photochemical Formation of Methylhydroperoxide in Dissolved Organic Matter Solutions

Sun

Lian

et al. 2020

Environ. Sci. Technol.

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Although it is known that the solar irradiation of chromophoric dissolved organic matter (CDOM) solutions generates H 2 O 2 , whether or not organic hydroperoxides (ROOHs) are photochemically formed remains unclear. This study employs high-performance liquid chromatography with the postcolumn enzymatic derivatization method to examine whether ROOHs can be formed in CDOM solutions under simulated solar irradiation. Methylhydroperoxide (MHP) is the only identified ROOH under our experimental conditions, and the quantum yields of MHP (Φ MHP ) vary from (1.09 ± 0.09) × 10 −6 to (4.95 ± 0.11) × 10 −6 in the tested CDOM solutions, including four reference natural organic matters and two effluent organic matters. The quantum yields of H 2 O 2 (Φ H 2 O 2 ) are simultaneously measured, and the ratios of Φ H 2 O 2 to Φ MHP range from 147 to 676. The formation of MHP is highly related to the presence of superoxide radical ions (O 2•− ) and methyl radicals (CH 3 •); therefore, a photoformation mechanism of MHP has been proposed. The photochemically generated CH 3• reacts with O 2 to yield CH 3 OO • . Subsequently, CH 3 OO • is reduced to MHP by O 2 •− . Our results also suggest that the yield of CH 3• to MHP under air-saturated conditions is 52% and increases to 98% under oxygensaturated conditions. The decays of MHP and H 2 O 2 are very similar in terms of photodegradation, hydrolysis, Fenton, and photo-Fenton reactions. This study can be useful to understand the photochemical formation of organic peroxides in surface waters.

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Toxicity Studies of Certain Organic Peroxides and Hydroperoxides

Cited by 40 publications

References 7 publications

The Subacute Inhalation Toxicity of 109 Industrial Chemicals

The Subacute Inhalation Toxicity of 109 Industrial Chemicals

N-acetylcysteine and hemodialysis treatment of a severe case of methyl ethyl ketone peroxide intoxication

Photochemical Formation of Methylhydroperoxide in Dissolved Organic Matter Solutions

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