Toxicity studies of Tithonia diversifolia A. Gray (Asteraceae) in rats

Elufioye, Taiwo O.; Alatise, Olusegun Isaac; Fakoya, Francis Adelade; Agbedahunsi, Joseph M.; Houghton, PJ

doi:10.1016/j.jep.2008.12.007

Cited by 45 publications

(23 citation statements)

References 9 publications

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“…The rats that were treated with 10 mg/kg LRE showed less intense morphological alterations. Similar renal damage was reported in a study describing the toxicology of the ethanolic extract of Tithonia diversifolia (Elufioye et al, 2009). In addition, Tithonia diversifolia also has secretory trichomes on the foliar surface, and the major compounds in the trichomes are STLs (Ambrósio et al, 2008).…”

Section: Groupsupporting

confidence: 84%

Renal toxicity caused by oral use of medicinal plants: The yacon example

Oliveira

Paula

Rocha

et al. 2011

Journal of Ethnopharmacology

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The renal damage was associated with increased blood glucose levels after prolonged oral administration of the AE. This observation suggested that the hypoglycaemic effect observed after treatment for 30 days in an earlier study is reversible and was likely the result of renal injury caused by the toxicity of yacon. Because STLs were detected in both AE and LRE, there is strong evidence that these terpenoids are the main toxic compounds in the leaves of the yacon. Based on our results, we do not recommend the oral use of yacon leaves to treat diabetes.

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Section: Groupsupporting

confidence: 84%

Renal toxicity caused by oral use of medicinal plants: The yacon example

Oliveira

Paula

Rocha

et al. 2011

Journal of Ethnopharmacology

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“…A. Gray has promising antiplasmodial activity, study by Elufioye et al (2009) showed that it is toxic to the liver and kidney therefore limiting its widespread use in the management of malaria.…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants used for management of malaria among the Luhya community of Kakamega East sub-County, Kenya

Mukungu

Abuga

Okalebo

et al. 2016

Journal of Ethnopharmacology

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BackgroundMalaria remains a major health problem worldwide especially in sub-Saharan Africa. In Kenya, 80% of the population is at risk of contracting the disease. Pregnant mothers and children under five years are the most affected by this disease. Antimalarial drug resistance poses a major threat in the fight against malaria necessitating continuous search for new antimalarial drugs. Due to inadequate and inaccessible health facilities, majority of people living in rural communities heavily depend on traditional medicine which involves the use of medicinal plants for the management of malaria. Most of these indigenous knowledge is undocumented and risks being lost yet such information could be useful in the search of new antimalarial agents.Aim of studyAn ethnobotanical survey was carried out among the Luhya community of Kakamega East sub-County, a malaria epidemic region, with the aim of documenting the plants used in the management of malaria.Materials and methodsSemi-structured questionnaires were used to collect information from 21 informants who included traditional medicine practitioners and other caregivers who had experience in use of plants in management of malaria. These were drawn from 4 villages located in Kakamega East sub-county, within Kakamega County based on their differences in topography. Information recorded included plant names, parts used, mode of preparation and administration and the sources of plant materials. A literature search was conducted using PubMed and google scholar to identify the reported traditional uses of these plants and studied antiplasmodial activities.ResultsIn this study, 57% of the informants were aged above 50 years and a total of 61% had either no formal education or had only attained primary school education. A total of 42 plant species belonging to 24 families were identified. Most plants used in the management of malaria in this community belonged to Lamiaceae (18%), Leguminosae (9%) and Compositae (9%) plant families. Plants mostly used included Melia azedarach L, Aloe spp, Ajuga integrifolia Buch. Ham, Vernonia amygdalina Del., Rotheca myricoides (Hochst.) Steane and Mabb, Fuerstia africana T.C.E.Fr., Zanthoxylum gilletii (De Wild.) P.G.Waterman and Leucas calostachys Oliv. Rumex steudelii Hochst.ex A. Rich and Phyllanthus sepialis Müll. Arg are reported for the first time in the management of malaria. Although Clerodendrum johnstonii Oliv. (Jeruto et al., 2011) and Physalis peruviana L.(Ramadan et al., 2015) are reported in other studies for management of malaria, no studies have been carried out to demonstrate their antiplasmodial activity.The plant parts mostly used were the leaves (36%) and stem barks (26%). Majority of these plants were prepared as decoctions by boiling and allowed to cool before administration (66%) while infusions accounted for 28% of the preparations. The literature mined supports the use of these plants for the management of malaria since most of them have demonstrated in-vitro and in-vivo antiplasmodial activities.ConclusionMost of t...

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“…Although, the animals treated with 5000mg/kg extract of T. diversifolia survived throughout the experiments, reports have shown that ethanolic and aqueous extracts of T. diversifolia affected liver function index and some haematological parameters (Elufioye et al, 2009;Oyewole et al, 2007). Hence, the need for toxicity tests involving heamatogical and histopathological investigations for all the extracts.…”

Section: Discussionmentioning

confidence: 98%