Toxicity Studies on the Methanolic Extract of Portulaca oleracea L. (Fam. Portulacaceae)

Musa, K. Y.; Ahmed, Amran; Ibrahim, G; ., O.E. Ojonugwa; Mohammed, Bisalla; Musa, Hassan Hussein; Danmalam, U.H.

doi:10.3923/jbs.2007.1293.1295

Cited by 13 publications

(2 citation statements)

References 3 publications

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“…On the other hand, purslane was reported to have weak or no cytotoxic activities in in vitro models. The LD 50 of methanolic extract in acute toxicity experiment on mice was 1853 mg/kg, suggesting that purslane is a moderately toxic plant according to WHO classification [34]. In addition, the clinical trial of purslane at dose 180 mg/day for 12 weeks in type 2 diabetes patients showed that purslane consumption is safe with no significant differences in hematologic, biochemistry, and urinalysis values between the purslane-treated and placebo groups [35].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown

Truong

Huynh

Dung

et al. 2019

Parkinson's Disease

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Parkinson’s disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders. There have been numerous in vitro and in vivo models developed to study mechanisms of PD and screen potential drug. Recently, dUCH-knockdown Drosophila model has been established and showed potential for screening antioxidants for PD treatment. The dUCH-knockdown Drosophila model of PD mimics most of main PD pathologies such as dopaminergic neurons degeneration, locomotor dysfunction, and shortage of dopamine in the brain. Common purslane (Portulaca oleracea L.) is a nutritious vegetable containing a variety of antioxidants, levodopa, and dopamine, a neurotransmitter closely related to PD. Purslane has been reported to exert neuroprotective effects against several neurotoxins including rotenone and 6-OHDA in PD models. However, the recent data have not provided sufficient evidence for using purslane to treat PD or decelerate disease progression. Therefore, in this study, we utilized dUCH-knockdown fly to evaluate the capacity of purslane extracts for PD treatment. The results showed that purslane extracts improved locomotor ability in the larval stage and decelerated disease progression in the adult stage. Additionally, purslane extracts also reduced dopaminergic neuron degeneration. Taken together, our data strongly demonstrated that purslane extracts effectively rescued PD-like phenotypes in the fly model. This result contributed a foundation for further study on the application of purslane in PD treatment.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown

Truong

Huynh

Dung

et al. 2019

Parkinson's Disease

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“…These neurotransmitters may be responsible for increasing blood pressure in this model of hypertension in which dexamethasone intensifies the reactivity to vasopressor effects of catecholamines. There is no accurate data for toxicity profile of seeds Heart rate Time (day) (23). There are some reports for the alteration in oxalic acid content in P. oleracea extract based on the nitrogen concentration and nitrate/ammonium ratio in the nutrient solutions (24).…”

Section: Discussionmentioning

confidence: 99%

Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

Safaeian¹,

Baniahmad²,

Esfandiari³

et al. 2017

J Herbmed Pharmacol

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The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasoneinduced hypertensive rats. Therefore, it is recommended that its using be avoided in hypertensive patients receiving glucocorticoids. Please cite this paper as: Introduction:Portulaca oleracea is used as a nutritional and medicinal plant. The aim of this study was to assess the effect of hydroalcoholic extract of P. oleracea seeds in dexamethasone -induced hypertension in rats. Methods: For induction of hypertension, dexamethasone (30 µg/kg/d, subcutaneously) was administered for 14 days. Animals received P. oleracea extract as a pretreatment at various doses of 100, 200 and 400 mg/kg/d orally from 4 days before dexamethasone administration and during the test period. Systolic blood pressure (SBP) and heart rate were measured using tailcuff method. The weight of thymus gland was estimated as a marker of glucocorticoid activity. Results: Dexamethasone injection significantly increased SBP (P < 0.001) while decreased the body and thymus weights (P < 0.05 and P < 0.001, respectively). Oral administration of P. oleracea could not prevent rising in SBP and decreasing in thymus weight. It also increased heart rate in hypertensive rats at the dose of 400 mg/kg/d (P < 0.05). Conclusion:The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasone-induced hypertensive rats. Hence, it should be used with caution in hypertensive patients receiving glucocorticoids.

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Neuroprotective Effects of Portulaca oleracea and Portulaca quadrifida Linn

Buabeid

Gacem

Fujihashi

et al. 2021

Medicinal Herbs and Fungi

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Toxicity Studies on the Methanolic Extract of Portulaca oleracea L. (Fam. Portulacaceae)

Cited by 13 publications

References 3 publications

Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown

Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown

Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

Neuroprotective Effects of Portulaca oleracea and Portulaca quadrifida Linn

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