Toxicity study of Bidens pilosa in animals

Liang, Y.; Lin, Chuan-Ju; Yang, Cheng-Ying; Chen, Yung‐Hsiang; Yang, Mengting; Chou, Fu-Shiuan; Yang, Wen‐Chin; Chang, Ching‐Cheng

doi:10.1016/j.jtcme.2019.04.002

Cited by 15 publications

(13 citation statements)

References 16 publications

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“…It has high nutritional value both as food and forage ( Cheng and Jia, 2002 ; Bartolome et al., 2013 ). According to previous studies, this species has no adverse effects in mice or chickens when given as 5% or less of the total food intake ( Liang et al., 2020 ). B. pilosa has a beneficial impact on growth performance and protozoan infection in chickens, probably via modulation of gut bacteria ( Chang et al., 2016 ).…”

Section: Discussionmentioning

confidence: 89%

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

Yang

Luo

Gan³

et al. 2021

Plant Diversity

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In the Qinba mountainous area of Central China, pig farming has a significant impact on the growth of the rural economy and has substantially increased farmer incomes. Traditional knowledge plays an important role in the selection of forage plant species for pig farming by local people. This study aimed to identify the forage plants used for pig feeding and to catalog indigenous knowledge regarding their use. During 2016 and 2017, ethnobotanical surveys and inventories were conducted in Zhuxi County, Hubei Province, China. Data were collected using semi-structured interviews, key informant reports, free listings, guided field walks, and participatory observations with 77 households in 16 villages in 13 towns/townships. The obtained data were analyzed using a relative frequency citation (RFC) index. Overall, 145 wild forage plants from 91 genera and 31 families were recorded. The most cited families were Asteraceae, Polygonaceae, Urticaceae, Amaranthaceae, Fabaceae, Cruciferae, Caryophyllaceae, and Lamiaceae. Whole plants (75.9%) and tender leaves (12.4%) were the most frequently used parts of the plants. Most of the forage plants were herbaceous (88.9%). Almost all forage plants could be collected throughout the year (62.7%). Raw and cooked were the two main preparation methods. The most frequently cited species were Taraxacum mongolicum , Bidens pilosa , Sonchus oleraceus , Pilea verrucosa , and Pilea pumila var. obtusifolia . A total of 14 species were identified as the top forage plants in Zhuxi County based on their RFC values (RFC value greater than 0.5). Local people possess rich traditional knowledge about the utilization and management of forage plants for pig feeding. However, the maintenance of this traditional knowledge may be seriously threatened by changes in pig feeding modes and the lack of successors. Appropriate strategies and action plans have been suggested for the conservation of traditional knowledge associated with biodiversity and the sustainable use of forage species resources. These include 1) taking targeted measures to protect forage resources and associated traditional knowledge; 2) strengthening research on the forage plants with the highest RFC values for nutritional value, digestibility, other functions, and ecological status; and 3) enhancing the identification of poisonous forage plants.

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Section: Discussionmentioning

confidence: 89%

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

Yang

Luo

Gan³

et al. 2021

Plant Diversity

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“…16,18 Furthermore, it is well established in the literature that such extracts are relatively safe regarding distinct toxicological endpoints, comprising acute/sub-chronic toxicity, genotoxicity, and histopathological alterations in vital organs. [25][26][27][28][29] The present clinical trial showed that the formulation did not cause any adverse reactions in the mucosa of the oral cavity or any systemic complications in the patients with cancer included in this study (Figure 5). Corroborating our findings, there is evidence that CL is safe and non-toxic up to doses of 100 mg/kg/day in animals and 12 g/day in humans.…”

Section: Discussionmentioning

confidence: 97%

Safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and Bidens pilosa L. extract in the prevention and treatment of radiochemotherapy‐induced oral mucositis: Triple‐blind, randomized, placebo‐controlled, clinical trial

et al. 2021

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Background: Oral mucositis (OM) is the significant complication of radio/ chemotherapy treatment. This study evaluated the safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and Bidens pilosa L. (FITOPROT) in the prevention/treatment of OM.Methods: Sixty-two patients were randomized into the group's intervention and placebo. Adverse effect assessment, OM grading, pain, and saliva collection were carried at the 1st, 15th, 21st, and final of radiotherapy (RT). Inflammatory salivary mediators were measured. Results: FITOPROT decreased the severity of OM from the 15th to the final RT, while the placebo showed an increase in the severity (p < 0.05). Intervention group had a lower number of patients with ulcerated OM at the final RT (p < 0.05). Phytomedication prevented increases of IL-8 levels and reduced the salivary nitrite during RT.

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“…Some studies on acute, subchronic, and chronic toxicities of B. pilosa have been conducted in rodents. Liang and colleagues showed that administration of B. pilosa whole plant at 1 g/kg body weight (BW) for 24 weeks, a dosage of close to 10% of food, in mice showed no toxicity as evidenced by their food intake, water consumption, serum biochemistry, hematology, urine analysis, BW, mortality, organ weight, genotoxicity, and organ histopathology (Liang et al., 2019). Similar results were also obtained in chickens fed with B. pilosa for 28 days.…”

Section: Nutritional Value and Safetymentioning

confidence: 99%

Bidens pilosa: Nutritional value and benefits for metabolic syndrome

et al. 2021

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The genus Bidens (Asteraceae) encompasses over 240 different species. One of them is Bidens pilosa L. that is an easy-to-grow perennial, and broadly distributed in tropical and subtropical regions of the world. This plant has been regarded as an edible plant by the Food and Agriculture Organization of the United Nations since 1975, and has been traditionally used as a food and medicine in America, Africa, and Asia. B. pilosa has been claimed to possess active compounds with more than 40 distinct bioactivities. Although considerable progress has been made in studying the phytochemistry and biology of B. pilosa and its compounds over recent years, a critical review of its dietary functions for metabolic syndrome is unavailable. The present review summarizes the nutrition, benefits, phytochemistry, and safety of B. pilosa with respect to metabolic syndrome. As well as highlighting studies of the use of B. pilosa for metabolic syndrome, scientific evidence regarding the antimetabolic action, mechanism, and application of this species and its active phytochemicals are discussed. This review consolidates information for further study into the medicinal benefits of the compounds in this plant.

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Toxicity study of Bidens pilosa in animals

Cited by 15 publications

References 16 publications

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China

Safety and efficacy of a mucoadhesive phytomedication containing curcuminoids and Bidens pilosa L. extract in the prevention and treatment of radiochemotherapy‐induced oral mucositis: Triple‐blind, randomized, placebo‐controlled, clinical trial

Bidens pilosa: Nutritional value and benefits for metabolic syndrome

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