Toxicity Study of Ricinus cummunis Lnn Seed Suspension in Female Wister Albino Rats

Muhammad, Bawa Yusuf; Alhassan, A. J.; Jaafaru, I

doi:10.9734/ijbcrr/2015/17511

Cited by 7 publications

(8 citation statements)

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“…The observed reduction in the activity and behavioral changes of the mice at all doses of the extract in this work may be due to the reduction of food intake by the mice over time which probably affected the function of many organsystems including the central nervous system. The serum levels of AST, ALT and ALP showed a statistically significant increase in both female and male mice treated with the high dose (1000 mg/kg/day) of the extract (Tables 1&2). Another study [13] also corroborated our findings with similar significant increment observed in the serum levels of AST, ALT and ALP in rats treated with high doses of RC seed suspension in their work. However, this is disproved by another report which showed significant decrease in serum levels of AST and ALP and significant increase in the levels of ALT in mice treated with the ethanolic leaves extract of RC for two weeks (acute toxicity study) [15].…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, mice treated with 250mg/kg, 500mg/kg and 1000mg/kg per day of the extract were observed to have multiple behavioral changes such as: depression, reduced locomotion, fatigue, head drooping, sleepiness, fur erection and fast breathing. In support of our study, Muhammad et al [13] revealed that behavioral changes such as depression, sluggishness, and mild diarrhea (in their acute toxicity study) as well as decreased appetite, increased water consumption and frequent urination (in their sub-chronic toxicity study) were observed, especially in those rats given the highest dose of the seed suspension of Ricinus communis. In contrast, Sadashiv [14] reported that mice treated with different dose levels of RC leaf extract showed no significant changes in behavior before and after the administration.…”

Section: Discussionsupporting

confidence: 89%

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Biochemical and Pathological Assessment of Ricinus Communis Leaf Extract Administration on Liver and Kidney in Mice

Gebeslassie

Ekanem

Gebrelibanos

et al. 2019

IJMBS

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Background: Medicinal plants remain the mainstay for primary healthcare. The present study evaluated the effects of sub-acute administration of Ricinus communis fresh leaves’ methanolic extract on the histopathology and biochemistry of the liver and kidney in Swiss albino mice. Methods: 24 male and female mice were randomly assigned into four equal groups. Group I (control) received 5% tween 80 orally, while the treated groups; II, III and IV received oral Ricinus communis extract at 250mg/kg/day, 500mg/kg/day, and 1000 mg/kg/day for 28 consecutive days, respectively. Tissue processing, staining and biochemical analysis were used to assess the changes induced histopathologically and biochemically on the liver and kidney tissues. Results: Female treated mice showed significant weight changes while male treated mice showed no changes. Histopathological alterations in liver and kidney sections were observed both in male and female mice. Serum levels of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase showed significant changes in both sexes. There were no significant changes in serum creatinine at all doses and in both sexes Conclusion: Methanolic extracts of Ricinus communis fresh leaves had hepatotoxic and nephrotoxic effects. Key words: Histopathology; Ricinus communis; liver; kidney; biochemical

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Biochemical and Pathological Assessment of Ricinus Communis Leaf Extract Administration on Liver and Kidney in Mice

Gebeslassie

Ekanem

Gebrelibanos

et al. 2019

IJMBS

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“…leucocephala poisoning [ 101 ]. The toxicological profile of Cannabis sativa intoxication is directly related to the proportion between the concentrations of ingested sample and mainly symptoms are related to the central nervous system [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

Phytotoxicological study of selected poisonous plants from Azad Jammu & Kashmir

et al. 2022

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Poisonous plants cause tremendous economic losses to the livestock industry. These economic losses are deterioration in their health, decreased productivity, deformed offspring, and reduced longevity. The current study is the first comprehensive report on poisonous plants of Azad Jammu and Kashmir which systematically documents the phytotoxicological effect and mode of action in livestock. The information was gathered from 271 informants including 167 men and 104 women through semi-structured interviews and literature search through available databases. The data collected through interviews was analyzed with quantitative tools viz. the factor informant consensus and fidelity level. A total of 38 species of flowering plants belonging to 23 families and 38 genera were reported. Family Asteraceae (5 spp) was the most dominant, followed by Solanaceae (4 spp), Fabaceae (4 spp), Euphorbiaceae (4 spp) and Convolvulaceae (3 spp). Among all the species collected, herbs were the dominant life form (22 spp, 57.89%), trailed by shrubs (11 spp, 28.95%), and trees (5 spp, 13.16%). Whole plant toxicity was reported to be the highest (15 spp, 39.47%), followed by leaf toxicity (12 spp, 31.58%), seed toxicity (4 spp, 7.89%), fruit toxicity (3 spp, 10.53%), latex toxicity (2 spp, 5.26%), flowers toxicity (1 spp, 2.63%), and berries toxicity (1 spp, 2.63%). The most toxic route of administration was found oral (39 spp, 40.63%), followed by intraperitoneal (24 spp, 25%), and intravenous (21 spp, 21.88%). The most commonly affected organ was found liver (20.41%), followed by gastrointestinal tract (20.341%), CNS (16.33%), skin (14.29%), kidneys (12.24%), lungs (4.04%), reproductive organs (2.04%), spleen (1.75%), blood (1.75%), heart (1.75%), urinary tract (1.75%), and pancreas (1.75%). The maximum Fic value was found for dermatological disorders (0.91), followed by the endocrine system (0.90), gastrointestinal (0.82), neurology (0.77), nephrology (0.67), cardiovascular (0.67), urinary (0.67), respiratory (0.60), sexual (0.60) disorders. Senecio vulgaris, and Ageratum conyzoides were the most important plants with fidelity level (0.95) and (0.87). Nerium oleander, Lantana camara, Leucaena leucocephala, and Ricinus communis were the important poisonous plant with maximum fidelity level (100%). Ricinus communis with reported lowest LD50 (<20 mg/kg) was the top-ranked poisonous plant followed by Lantana camara and Justicia adhatoda (25–50 mg/kg), Nerium Oleander (157.37 mg/kg), and Datura innoxia (400 mg/kg). We found that knowledge about poisonous plants is less prevailing in the rural areas of Azad Kashmir compared to the knowledge about medicinal plants and poisonous nature of reported plants is due to production of toxic substances and presence of essential oils.

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“…According to Ahmad et al (2016), the name Ricinus communis is derived from two Latin words: 'ricinus', which is the Latin name for the Mediterranean sheep tick (Ixodesricinus), to which the castor plant seed has similarities, and 'communis' which means common. Although called a "castor bean plant," it is not a true bean (Muhammad et al, 2015). The plant is known as "kharouâa" in Arabic, "ricin" in French, and locally in Nigeria as Laraa in Yoruba; Ogilisi in Igbo; Zurman in Hausa and Kpamfini gulu in Nupe (Ghnimi et al, 2014;Muhammad et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Phytochemical Analysis and Antimicrobial Activity of Ricinus communis Linn. Seed oil

Muhammad,

Daniyan

2024

USci

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Ricinus communis (R. communis) is a plant in the spurge family that has been traditionally used to treat numerous ailments. The study aims to evaluate the phytochemicals present in R. communis seed oil and its antimicrobial efficacy. The phytochemicals were quantified using standard procedures, and antimicrobial activity was carried out using broth dilution method at -100, 50, 25, and 12.5 mg/ml of the seed oil against Staphylococcus aureus, Escherichia coli, Salmonella sp., Aspergillus niger, and Aspergillus flavus. Alkaloids, flavonoids, phenols, saponins, and tannins were detected with varying concentrations. The highest MIC value, 100 mg/ml, was recorded against fungal isolates, while the lowest, 12.5 mg/ml, was recorded against S. aureus. Similarly, the highest MLC was recorded against the fungal isolates, and the lowest value of 50 mg/ml was recorded against all the bacterial species. The seed oil contained an appreciable amount of phytochemicals and exhibited antimicrobial activity against the tested isolates.

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Toxicity Study of Ricinus cummunis Lnn Seed Suspension in Female Wister Albino Rats

Cited by 7 publications

References 0 publications

Biochemical and Pathological Assessment of Ricinus Communis Leaf Extract Administration on Liver and Kidney in Mice

Biochemical and Pathological Assessment of Ricinus Communis Leaf Extract Administration on Liver and Kidney in Mice

Phytotoxicological study of selected poisonous plants from Azad Jammu & Kashmir

Quantitative Phytochemical Analysis and Antimicrobial Activity of Ricinus communis Linn. Seed oil

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