Toxicity to goats ofIpomoea carnea

Idris, O. F.; Tartour, G.; Adam, Safwaan; Obeid, H. M.

doi:10.1007/bf02236148

Cited by 19 publications

(18 citation statements)

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“…18,19,23,25,36,38 Clinical signs of acute and chronic I. carnea poisoning probably reflect impairment of tissues affected by vacuolar lesions, particularly nervous tissue, and range from general depression and ruminal and digestive disorders to staggering gait, reluctance to move, abduction and weakness of the hind limbs, general weakness, tremors, dullness, incoordination, posterior paresis and paralysis, diarrhea, lacrimation, nasal discharge, and pallor of visible mucous membranes. 10,16,21,33,35 Hyperaesthesia, head tremors, and nystagmus were observed in some of the affected goats.…”

Section: Discussionmentioning

confidence: 99%

“…carnea) 8,16 has been diagnosed in Karawag, Indonesia. 7 Although the toxicity of the plant and its effects on the nervous system have been reported by these and other authors, a detailed histopathologic examination of the nervous system was either inconclusive or not done, 10,16,21,34,35 and the toxic principle(s) and mechanism of intoxication was not determined.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier reports of I. carnea poisoning came from Sudan and India, 21,35 and toxicity in livestock after the consumption of I. crassicaulis (ϭI. carnea) 8,16 has been diagnosed in Karawag, Indonesia.…”

Section: Discussionmentioning

confidence: 99%

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A Lysosomal Storage Disease Induced by Ipomoea Carnea in Goats in Mozambique

et al. 1999

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Abstract.A novel plant-induced lysosomal storage disease was observed in goats from a village in Mozambique. Affected animals were ataxic, with head tremors and nystagmus. Because of a lack of suitable feed, the animals consumed an exotic hedge plant growing in the village that was identified as Ipomoea carnea (shrubby morning glory, Convolvulaceae). The toxicosis was reproduced by feeding I. carnea plant material to goats. In acute cases, histologic changes in the brain and spinal cord comprised widespread cytoplasmic vacuolation of neurons and glial cells in association with axonal spheroid formation. Ultrastructurally, cytoplasmic storage vacuoles in neurons were membrane bound and consistent with lysosomes. Cytoplasmic vacuolation was also found in neurons in the submucosal and mesenteric plexuses in the small intestine, in renal tubular epithelial cells, and in macrophage-phagocytic cells in the spleen and lymph nodes in acute cases. Residual alterations in the brain in chronic cases revealed predominantly cerebellar lesions characterized by loss of Purkinje neurons and gliosis of the Purkinje cell layer. Analysis of I. carnea plant material by gas chromatography-mass spectrometry established the presence of the mannosidase inhibitor swainsonine and 2 glycosidase inhibitors, calystegine B 2 and calystegine C 1 , consistent with a plant-induced ␣-mannosidosis in the goats. The described storage disorder is analogous to the lysosomal storage diseases induced by ingestion of locoweeds (Astragalus and Oxytropis) and poison peas (Swainsona).Most lysosomal storage diseases are genetic disorders, 32 but a few are induced by the ingestion of toxic plants such as the locoweeds (Astragalus and Oxytropis spp.) from North America, South America, and China 36 and the poison peas (Swainsona spp.) found in Australia. 13,15,25 These plants belong to the family Fabaceae (Leguminosae) and contain the indolizidine alkaloid swainsonine, an inhibitor of lysosomal ␣-mannosidase and mannosidase II. 12,28 The action of swainsonine results in a lysosomal storage disorder that closely mimics ␣-mannosidosis, characterized by the accumulation of incompletely processed oligosaccharides rich in ␣-mannosyl and ␤-N-acetyl glucosamine moieties. 2,12 Histologically, there are cytoplasmic vacuoles in cells of the nervous system and other tissues. Neurons, as is the case in most lysosomal storage diseases, are most consistently affected because

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Lysosomal Storage Disease Induced by Ipomoea Carnea in Goats in Mozambique

et al. 1999

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“…After prolonged periods of I. carnea intake, animals exhibit a variety of clinical signs like depression, general weakness, loss of body weight, staggering gait, muscle tremors, ataxia, posterior paresis, and paralysis, followed by death if the ingestion is not interrupted (Idris et al, 1973;Damir et al, 1987;De Balogh et al, 1999). These toxic effects are attributed to the polyhydroxylated alkaloids swainsonine, calystegines B 1 , B 2 , C 1 and 2α-2β-dihydroxynortropane detected in I. carnea (Asano et al, 2001), chemical toxins present mainly in the leaves of the plant.…”

Section: Introductionmentioning

confidence: 99%

Rats offspring exposed to Ipomoea Carnea and handling during gestation: neurochemical evaluation

Schwarz

Hosomi

Flório

et al. 2007

Braz. arch. biol. technol.

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“…40 Ipomoea carnea has been responsible for intoxication of ruminants throughout tropical regions worldwide. 3,11,22 Ipomoea carnea poisoning outbreaks occur annually during the dry season, when food is scarce.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Morphologic Changes in Ewes and Fetuses Poisoned by Ipomoea Carnea Subspecies Fistulosa

et al. 2011

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Abstract. Intoxication with Ipomoea carnea has been reported in goats, sheep, and cattle in tropical regions worldwide. The disease has been characterized only in goats; therefore, the present study was conducted in sheep. Nine animals were fed feed rations that contained 3 different concentrations of Ipomoea carnea subsp. fistulosa. Individual intake varied between 10.5 and 135.2 g of fresh plant per kilogram of body weight (BW) per day. Animals first showed clinical signs between day 43 and day 63. The maximum survival time was 133 days. Sheep presented with weight loss and neurologic abnormalities. Neurologic signs were dominated by marked depression, abnormal behavior, and musculoskeletal weakness, with poorly defined motor and proprioceptive deficits. In mature animals, cytoplasmic vacuolation, consistent with accumulation of secondary lysosomes, affected neurons, astrocytes, exocrine pancreatic acinar epithelia, hepatocytes and Kupffer cells, renal tubular epithelia, thyroid follicular epithelia, cortical adrenal epithelia, endothelia and perivascular cells, and macrophages in lymph nodes and spleen. In the central nervous system, there was axonal degeneration and astrogliosis. Abortion was observed as early as day 22 of the trial. In fetal tissues and placenta of chronically poisoned ewes, cytoplasmic vacuolation was histologically detected in neurons, exocrine pancreatic acinar epithelia, hepatocytes, renal tubular epithelia, and thyroid follicular epithelia. All the sheep developed a glycoprotein storage disease, with lysosomal accumulation of N-glycosidically linked oligosaccharides, which was indistinguishable from that induced by the alkaloid swainsonine alone.

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Toxicity to goats ofIpomoea carnea

Cited by 19 publications

References 1 publication

A Lysosomal Storage Disease Induced by Ipomoea Carnea in Goats in Mozambique

A Lysosomal Storage Disease Induced by Ipomoea Carnea in Goats in Mozambique

Rats offspring exposed to Ipomoea Carnea and handling during gestation: neurochemical evaluation

Clinical and Morphologic Changes in Ewes and Fetuses Poisoned by Ipomoea Carnea Subspecies Fistulosa

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