Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges

Ahmad, Farooq; Wang, Xiao Yan; Li, Wanwan

doi:10.1002/adfm.201904268

Cited by 24 publications

(23 citation statements)

References 246 publications

(261 reference statements)

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“…Metabolomics is a powerful tool to evaluate the effects of nanomaterials on human cells 42 – 44 as it allows the detection of metabolic changes that cannot be quantified by other techniques. An NMR-based metabolomics approach was previously used to demonstrate that low concentrations of GO and FLG (5 µg/mL) induce metabolic changes in HaCaT cells 23 .…”

Section: Resultsmentioning

confidence: 99%

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Frontiñán-Rubio

Gómez

González

et al. 2020

Sci Rep

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Small few-layer graphene (sFLG), a novel small-sized graphene-related material (GRM), can be considered as an intermediate degradation product of graphene. GRMs have a promising present and future in the field of biomedicine. However, safety issues must be carefully addressed to facilitate their implementation. In the work described here, the effect of sub-lethal doses of sFLG on the biology of human HaCaT keratinocytes was examined. A one-week treatment of HaCaTs with sub-lethal doses of sFLG resulted in metabolome remodeling, dampening of the mitochondrial function and a shift in the redox state to pro-oxidant conditions. sFLG raises reactive oxygen species and calcium from 24 h to one week after the treatment and this involves the activation of NADPH oxidase 1. Likewise, sFLG seems to induce a shift from oxidative phosphorylation to glycolysis and promotes the use of glutamine as an alternative source of energy. When sub-toxic sFLG exposure was sustained for 30 days, an increase in cell proliferation and mitochondrial damage were observed. Further research is required to unveil the safety of GRMs and degradation-derived products before their use in the workplace and in practical applications.

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Section: Resultsmentioning

confidence: 99%

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Frontiñán-Rubio

Gómez

González

et al. 2020

Sci Rep

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Section: Introductionmentioning

confidence: 99%

“…Despite the rapid developments in these fields, there remain a number of challenges in nanotechnology development. The key issues are the health risk and safety concern of ENPs, especially in the field of nanomedicine ( Susan et al, 2018 ; Ahmad et al, 2019 ). Numerous studies have reported the ENP-associated toxicity to zebra fish ( Lakshmi et al, 2019 ; Bakshi, 2020 ), macroalgae ( Sfriso et al, 2019 ), animals ( Jia et al, 2017 ; Teng et al, 2019 ), and even human beings ( Guo et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

In vivo Protein Corona Formation: Characterizations, Effects on Engineered Nanoparticles’ Biobehaviors, and Applications

Bai

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Understanding the basic interactions between engineered nanoparticles (ENPs) and biological systems is essential for evaluating ENPs’ safety and developing better nanomedicine. Profound interactions between ENPs and biomolecules such as proteins are inevitable to occur when ENPs are administered or exposed to biological systems, for example, through intravenous injection, oral, or respiration. As a key component of these interactions, protein corona (PC) is immediately formed surrounding the outlayer of ENPs. PC formation is crucial because it gives ENPs a new biological identity by altering not only the physiochemical properties, but also the biobehaviors of ENPs. In the past two decades, most investigations about PC formation were carried out with in vitro systems which could not represent the true events occurring within in vivo systems. Most recently, studies of in vivo PC formation were reported, and it was found that the protein compositions and structures were very different from those formed in vitro. Herein, we provide an in-time review of the recent investigations of this in vivo PC formation of ENPs. In this review, commonly used characterization methods and compositions of in vivo PC are summarized firstly. Next, we highlight the impacts of the in vivo PC formation on absorption, blood circulation, biodistribution, metabolism, and toxicity of administered ENPs. We also introduce the applications of modulating in vivo PC formation in nanomedicine. We further discuss the challenges and future perspectives.

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“…This review aimed to deliver a comprehensive view of AgNPs for diagnostics and therapeutic treatment of several cancer genomes and metabolomes from multi-omics technology (i.e., genomics, transcriptomics, proteomics, and metabolomics). The multi-omics sciences have globally matured to target structural, molecular, and phenotypic changes in systems biology [142,143]. Here, we have carefully accounted for the variability of several genomes, proteomes, and metabolomes which are mostly highly listed in terms of AgNPs-based targeting therapy in tumor microenvironmental locations.…”

Section: Conclusion Challenges and Future Perspectivesmentioning

confidence: 99%

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Ganesan

Jang

Suh

et al. 2020

Cancers

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Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional heterogeneity, microenvironmental differences, and reversible changes in cell properties (e.g., chemotherapy). There is a lack of targets for processes involved in tumor cellular heterogeneity, such as metabolic clampdown, cytotoxicity, and genotoxicity, which hinders microenvironmental biology. Proteogenomics and chemical metabolomics are important tools that can be used to study proteins/genes and metabolites in cells, respectively. Chemical metabolomics have many advantages over genomics, transcriptomics, and proteomics in anticancer therapy. However, recent studies with AgNPs have revealed considerable genomic and proteomic changes, particularly in genes involved in tumor suppression, apoptosis, and oxidative stress. Metabolites interact biochemically with energy storage, neurotransmitters, and antioxidant defense systems. Mechanobiological studies of AgNPs in cancer metabolomics suggest that AgNPs may be promising tools that can be exploited to develop more robust and effective adaptive anticancer therapies. Herein, we present a proof-of-concept review for AgNPs-based proteogenomics and chemical metabolomics from various tumor cells with the help of several technologies, suggesting their promising use as drug carriers for cancer therapy.

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Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges

Cited by 24 publications

References 246 publications

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

Sublethal exposure of small few-layer graphene promotes metabolic alterations in human skin cells

In vivo Protein Corona Formation: Characterizations, Effects on Engineered Nanoparticles’ Biobehaviors, and Applications

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

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