Toxico-Neurological Effects of Piroxicam in Monogastric Animals

Saganuwan, Saganuwan Alhaji; Orinya, Orinya Agbaji

doi:10.4137/jen.s40144

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Human equivalent dose (HED) formula was used to determine therapeutic dose of (5 mg/kg) piroxicam in WAD goats. 23,24 HED = animal dose × animal K m H k m whereas K m = Body surface area Body weight But human BSA = H 0.528 × W 0.528 × K. Goat BSA = BW 0.67 × 10 −3 . …”

Section: Methodsmentioning

confidence: 99%

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Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

2017

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Cases of Stevens-Johnson syndrome have been increasingly reported in Nigeria by individuals who consumed meat products of animals especially goats injected sulfonamides. Hence, tissue distribution and residues of intramuscular sulfadimidine were studied in West African Dwarf (WAD) goats. Twenty goats divided into two groups of 10 each (five males; five females) weighing 10.4 ± 1.63 kg were administered intramuscular sulfadimidine (100 mg/kg body weight), and the second group was coadministered 5 mg/kg of piroxicam via right and left thigh muscle, respectively. Samples of the liver, kidney, spleen, heart, lung, intestine, brain, and skeletal muscle were collected into sterile cellophane bags. Two untreated goats were killed and used for preparation of tissue standards. The tissue samples were stored frozen for analysis. High concentration of sulfadimidine residues was found in all the tissues of goats administered sulfadimidine as well as tissues of goats coadministered sulfadimidine/piroxicam for up to 30 days postdrug administration. Generally, residues of sulfadimidine were observed to be significantly higher than the acceptable limit (0.1 ppm). Hence, consumption of meats from WAD goats administered sulfadimidine may pose very high risk of Stevens-Johnson syndrome in sensitive humans. As such consumption of such meats should be avoided.

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Section: Methodsmentioning

confidence: 99%

“…Human equivalent dose (HED) formula was used to determine therapeutic dose of (5 mg/kg) piroxicam in WAD goats. 23,24 HED…”

Section: Drugs and Dosagementioning

confidence: 99%

Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

2017

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“…In previous studies, the effective dose of piroxicam with analgesic effects in mice was determined to be 30 mg/kg. 14 Therefore, in the present study, two doses, 15 and 30 mg/ kg were used.…”

Section: Study Population (Animals)mentioning

confidence: 99%

Comparison of Analgesic Effect of Rosmarinic Acid With Piroxicam in Mice

Moradi

Saberi

Salkuyeh

et al. 2022

Int J Basic Sci Med

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Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used drugs in the treatment of pain and inflammation. Although, their side effects i.e.; gastrointestinal and renal adverse effects, limit the use of these drugs. Therefore, investigating new compounds with higher efficacy and fewer side effects is considerable issue. In this study, the analgesic activity of rosmarinic acid at different doses was compared with piroxicam (known standard NSAID).Methods: To evaluate the analgesic effects of rosmarinic acid, two well-known methods, Hot plate, and Tail-flick, were used. The experiments were performed in 10 groups (6 male mice per group) including the experimental groups (rosmarinic acid), the positive control group (piroxicam), and the negative control group (normal saline). All administrations were through intraperitoneal injection. The obtained data were analyzed separately by SPSS software and an independent student t test.Results: Rosmarinic acid at doses of 10 mg/kg and higher had significant analgesic effects compared with the control group, 30 minutes after injection in both hot plate and tail flick tests (P < 0.05). Concomitant injection of 50 mg/kg of rosmarinic acid with 15 mg/kg of piroxicam produced significant painkiller effects when compared with the dose of 15 mg/kg piroxicam injection alone.Conclusion: Rosmarinic acid was able to exert analgesic effects in pharmacological tests in a dose-dependent manner. Concomitant use of rosmarinic acid and piroxicam may lead to synergic pain relief, especially in acute and severe pain in patients, reducing the therapeutic dose of piroxicam and subsequently, its side effects.

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“…At present, non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are widely used in the treatment of inflammatory diseases ( Lane et al, 2017 ). Research has revealed that NSAIDs have the advantage of fast onset of action and are more commonly used in clinical practice, but pharmacokinetic and pharmacodynamic tests have shown that these drugs have side effects such as gastrointestinal mucosal damage ( Saganuwan and Orinya, 2016 ). Therefore, the development of new anti-inflammatory treatments is imperative.…”

Section: Introductionmentioning

confidence: 99%

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice

Liu,

Tao,

Shen

et al. 2023

Front. Pharmacol.

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Introduction: Inflammation is a defensive response of the body and the pathological basis of many diseases. However, excessive inflammation and chronic inflammation impair the homeostasis of the organism. Arachidonic acid (AA) has a close relationship with inflammation and is the main mediator of the pro-inflammatory response. Based on the prodrug principle, the new pharmaceutical compound aspirin eugenol ester (AEE) was designed and synthesized. However, the effects of AEE on key enzymes, metabolites and inflammatory signaling pathways in the AA metabolic network have not been reported.Methods: In this study, the anti-inflammation effects of AEE were first investigated in mice and RAW264.7 cells in LPS induced inflammation model. Then, the changes of the key enzymes and AA metabolites were explored by RT-PCR and targeted metabolomics. Moreover, the regulatory effects on NF–kB and MAPKS signaling pathways were explored by Western Blotting.Results: Results indicated that AEE significantly reduced the number of leukocyte and increased the lymphocyte percentage. AEE decreased the expression levels of IL-1β, IL-6, IL-8 and TNF-α both in vivo and in vitro. In the liver of mice, AEE downregulated the levels of AA, prostaglandin D2 (PGD2) and upregulated 12- hydroxyeicosatetraenoic acid (12-HETE). However, the changes of PGE2, PGF2α, 6-keto-prostaglandin F1α (6-KETO-PGF1α), 9-hydroxy-octadecenoic acid (9- HODE), 13-HODE, 15-HETE, docosahexaenoic acid (DHA) and thromboxane B2 (TXB2) were not significant. Additionally, it was found that AEE decreased the relative mRNA expression levels of p65 and p38 and the ratio of p-p65/p65.Discussion: It was concluded that AEE might inhibit the LPS-induced inflammatory response through the regulation of AA metabolism. This study provides the theoretical foundation for the development of AEE as a medicinal anti-inflammatory drug.

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Toxico-Neurological Effects of Piroxicam in Monogastric Animals

Cited by 7 publications

References 29 publications

Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

Effects of piroxicam on tissue distribution of sulfadimidine in West African Dwarf male and female goats

Comparison of Analgesic Effect of Rosmarinic Acid With Piroxicam in Mice

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice

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