Toxicogenomics — A novel opportunity to probe lupus susceptibility and pathogenesis

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

“…We suggest the best strategies might be those that combine computational and experimental techniques, and a systems pathology approach will ultimately lead to a better comprehension of the molecular effects of pharmaceuticals. These new approaches, which have been termed ''pharmacoepigenomics" or ''toxicoepigenomics" allow for the discovery of potential untoward effects of drugs early in the drug development program and might save significant time, effort, money, and even lives by eliminating potentially toxic drugs from the development pipeline [175].…”

Environment and lupus-related diseases

“…Such approaches should facilitate a more thorough understanding of the responses provoked by xenobiotics and the mechanisms of DILE and autoimmunity by identification of candidate genes or epigenetic factors. 20 Mixed connective tissue disease MCTD, a discrete entity, is usually a benign syndrome characterized by specific features of autoimmune diseases: SLE, systemic sclerosis (SyS), RA, and myositis, in the restricted presence of elevated titers of antibodies to RNP. This is an example where only one antibody is exclusively required for the basis of diagnosis.…”

“…This leads to induction of a polyclonal B-cell activation. 20 Pathogenic mechanisms include T and B-cell activation with interference of T-cell maturation, effects on cytokines, DNA methylation and formation of reactive metabolites. 21,22 Two mouse models exhibit accelerated systemic disease following UV exposure.…”

“…Such approaches should facilitate a more thorough understanding of the responses provoked by xenobiotics and the mechanisms of DILE and autoimmunity by identification of candidate genes or epigenetic factors. 20…”