Toxicokinetic analysis of the anticoagulant rodenticides warfarin &amp; diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)

Takeda, Katsuo; Manago, Kosuke; Morita, Ayuko; Kawai, Yusuke; Yasuo, Nobuaki; Sekijima, Masakazu; Ikenaka, Yoshinori; Hashimoto, Takuma; Minato, Ryuichi; Oyamada, Yusuke; Horikoshi, Kazuo; Suzuki, Hajime; Ishizuka, Mayumi; Nakayama, Shouta M.M.

doi:10.1016/j.ecoenv.2022.113971

Cited by 4 publications

(1 citation statement)

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“…Increasing the understanding of differences in protein binding, which can affect chemical distribution and excretion, is another opportunity for NAMs to be refined in the application of toxicokinetics for interspecies extrapolations. Computational analysis of binding predictions based on amino acid sequencing of target molecules can be used to predict the toxicity of anticoagulant rodenticides in different species that have varied mutations in the gene that encodes structural forms for the vitamin K 2,3‐epoxide reductase, the enzyme that recycles vitamin K to enable its reuse in activation of blood coagulation proteins (Bermejo‐Nogales et al, 2022; Takeda et al, 2022). For metals, differences in basal expression and induction potential of metallothioneins and other “metal chaperone” proteins could affect relative species sensitivities (Spurgeon et al, 2020).…”

Section: Solutions To Challengesmentioning

confidence: 99%

Wildlife ecological risk assessment in the 21st century: Promising technologies to assess toxicological effects

Rattner

Bean

Beasley

et al. 2023

Integr Envir Assess & Manag

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Despite advances in toxicity testing and the development of new approach methodologies (NAMs) for hazard assessment, the ecological risk assessment (ERA) framework for terrestrial wildlife (i.e., air‐breathing amphibians, reptiles, birds, and mammals) has remained unchanged for decades. While survival, growth, and reproductive endpoints derived from whole‐animal toxicity tests are central to hazard assessment, nonstandard measures of biological effects at multiple levels of biological organization (e.g., molecular, cellular, tissue, organ, organism, population, community, ecosystem) have the potential to enhance the relevance of prospective and retrospective wildlife ERAs. Other factors (e.g., indirect effects of contaminants on food supplies and infectious disease processes) are influenced by toxicants at individual, population, and community levels, and need to be factored into chemically based risk assessments to enhance the “eco” component of ERAs. Regulatory and logistical challenges often relegate such nonstandard endpoints and indirect effects to postregistration evaluations of pesticides and industrial chemicals and contaminated site evaluations. While NAMs are being developed, to date, their applications in ERAs focused on wildlife have been limited. No single magic tool or model will address all uncertainties in hazard assessment. Modernizing wildlife ERAs will likely entail combinations of laboratory‐ and field‐derived data at multiple levels of biological organization, knowledge collection solutions (e.g., systematic review, adverse outcome pathway frameworks), and inferential methods that facilitate integrations and risk estimations focused on species, populations, interspecific extrapolations, and ecosystem services modeling, with less dependence on whole‐animal data and simple hazard ratios. Integr Environ Assess Manag 2023;00:1–24. © 2023 His Majesty the King in Right of Canada and The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). Reproduced with the permission of the Minister of Environment and Climate Change Canada. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

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Section: Solutions To Challengesmentioning

confidence: 99%