Toxicokinetic of benzo[a]pyrene and fipronil in female green frogs (Pelophylax kl. esculentus)

Reynaud, Stéphane; Worms, Isabelle; Veyrenc, Sylvie; Portier, Julien; Maı̂tre, Anne; Miaud, Claude; Raveton, Muriel

doi:10.1016/j.envpol.2011.10.029

Cited by 32 publications

(36 citation statements)

References 52 publications

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“…In the adult R. temporaria force-fed with [ 14 C] DDT, the amount of radioactive residues was proportional to the lipid content of each organ with the higher residues in fat body, gall bladder, liver and kidney, and for females in the ovary. 42) A similar dependence of 14 C distribution in each organ was observed for X. laevis exposed to […”

Section: Bioconcentration Factorsupporting

confidence: 57%

“…The toxicological concern about an environmentally more persistent metabolite was reported for fipronil. 14) More residues of the sulfone metabolite than of fipronil were detected in the P. kl. esculentus frog in the water-exposure study.…”

Section: Bioconcentration Factormentioning

confidence: 99%

“…esculentus, implying no correlation of k U with log K ow . 14) More polar phenol tended to be eliminated faster after its intraperitoneal injection into adult Rana temporaria, but with no clear relationship between the initial depuration rate and log K ow (−0.2 to 3.3). 15) In contrast, the k D values of various polychlorinated biphenyls and polycyclic aromatic hydrocarbons injected into two frog species decreased in proportion to their log K ow (4 to 7).…”

Section: Uptake and Depurationmentioning

confidence: 99%

“…In contrast to bioconcentration, bioaccumulation through the dietary route has been experimentally examined in the few stud- 2, lindane (6 hr); 45) 3, parathion (4 days); 46) 4, fenthion (4 days); 46) 5, triclosan (4 days); 43) 6, fluoranthene (2 days); 17) 7, dieldrin (1 to 28 days); 24,35) 8, DDT (1 day); 24,41) 9, cypermethrin (1 day); 23) 10, deltamethrin (13 hr); 45) 11, fipronil (6 days); 14) 12, methoxychlor (1 day); 47) 13, benzo[a]pyrene (6 days).…”

Section: Bioconcentration Factormentioning

confidence: 99%

“…12,41) Since the BCF values were estimated on the 14 C basis, further studies determining pesticide residues in biota are needed to clarify the temperature effect.…”

Section: Bioconcentration Factormentioning

confidence: 99%

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Bioconcentration and metabolism of pesticides and industrial chemicals in the frog

Katagi

Ose

2014

J. Pestic. Sci.

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Exposure to pesticide residues is claimed to be one of the possible causes of frog decline. Knowledge of basic information on the uptake, metabolism and depuration processes of pesticides in the frog is needed to understand the relationship between exposure and toxic effects from their actual body burden, together with their bioconcentration. The hydrophobicity of pesticides and industrial chemicals was one of the most important factors controlling bioconcentration, similarly to fish, when frogs are exposed to contaminated water. Skin absorption was also a key route in the uptake process especially in the adult frog. The metabolic profiles in the frog, mainly examined by an intraperitoneal injection technique, were common to other aquatic species without any frog-specific transformation reaction. The effects of developmental stage, sex, species and environmental factors such as temperature were observed for bioconcentration and metabolism.

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Section: Bioconcentration Factorsupporting

confidence: 57%

Section: Bioconcentration Factormentioning

confidence: 99%

Section: Uptake and Depurationmentioning

confidence: 99%

Section: Bioconcentration Factormentioning

confidence: 99%

“…12,41) Since the BCF values were estimated on the 14 C basis, further studies determining pesticide residues in biota are needed to clarify the temperature effect.…”

Section: Bioconcentration Factormentioning

confidence: 99%

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Bioconcentration and metabolism of pesticides and industrial chemicals in the frog

Katagi

Ose

2014

J. Pestic. Sci.

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Soil organic matter content effects on dermal pesticide bioconcentration in American toads (Bufo americanus)

Meter

Glinski

Henderson

et al. 2016

Enviro Toxic and Chemistry

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Pesticides have been implicated as a major factor in global amphibian declines and may pose great risk to terrestrial phase amphibians moving to and from breeding ponds on agricultural landscapes. Dermal uptake from soil is known to occur in amphibians, but predicting pesticide availability and bioconcentration across soil types is not well understood. The present study was designed to compare uptake of 5 current‐use pesticides (imidacloprid, atrazine, triadimefon, fipronil, and pendimethalin) in American toads (Bufo americanus) from exposure on soils with significant organic matter content differences (14.1% = high organic matter and 3.1% = low organic matter). We placed toads on high‐ or low‐organic matter soil after applying individual current‐use pesticides on the soil surface for an 8‐h exposure duration. Whole body tissue homogenates and soils were extracted and analyzed using liquid chromatography–mass spectrometry to determine pesticide tissue and soil concentration, as well as bioconcentration factor in toads. Tissue concentrations were greater on the low‐organic matter soil than the high‐organic matter soil across all pesticides (average ± standard error; 1.23 ± 0.35 ppm and 0.78 ± 0.23 ppm, respectively), and bioconcentration was significantly higher for toads on the low‐organic matter soil (analysis of covariance p = 0.002). Soil organic matter is known to play a significant role in the mobility of pesticides and bioavailability to living organisms. Agricultural soils typically have relatively lower organic matter content and serve as a functional habitat for amphibians. The potential for pesticide accumulation in amphibians moving throughout agricultural landscapes may be greater and should be considered in conservation and policy efforts. Environ Toxicol Chem 2016;35:2734–2741. © 2016 SETAC.

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Comparative Studies on the Toxicokinetics of Benzo[a]pyrene in Pinctada martensii and Perna viridis

Wang

Cui

Cheng

et al. 2017

Bull Environ Contam Toxicol

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Research on the kinetics of Benzo[a]pyrene (B[a]P) bioaccumulation in the clam Pinctada martensii and mussel Perna viridis showed that the initial rate of uptake was directly related to the PAH concentrations in the ambient environment. The uptake and depuration rate constants were different at the four B[a]P exposure levels, which indicated that the toxicokinetic rate constants mainly depended on the exposure levels of pollutants to the environment. In addition, the uptake rate constants of B[a]P were higher than the depuration rate constants in the entire experiment. The comparison demonstrated that mussels release B[a]P more rapidly than clams. The bioconcentration factors (BCFs) of B[a]P varied from 3335 to 12892 in the clam and 2373-6235 in the mussel. These findings on the bioaccumulation kinetics for petroleum hydrocarbons, in association with the critical body residue, will be valuable when choosing sensitive organisms to assess the potential ecotoxicological risk to the marine environment.

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Toxicokinetic of benzo[a]pyrene and fipronil in female green frogs (Pelophylax kl. esculentus)

Cited by 32 publications

References 52 publications

Bioconcentration and metabolism of pesticides and industrial chemicals in the frog

Bioconcentration and metabolism of pesticides and industrial chemicals in the frog

Soil organic matter content effects on dermal pesticide bioconcentration in American toads (Bufo americanus)

Comparative Studies on the Toxicokinetics of Benzo[a]pyrene in Pinctada martensii and Perna viridis

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