Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

Osselaere, Ann; Devreese, Mathias; Goossens, Joline; Vandenbroucke, Virginie; Baere, Siegrid De; Backer, Patrick De; Croubels, Siska

doi:10.1016/j.fct.2012.10.006

Cited by 86 publications

(101 citation statements)

References 27 publications

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“…The mycotoxin adsorbing agent illite-ambrosite clay does not cause direct damage or irritation. However, feeding this clay mineral in combination with DON may result in higher concentrations of the mycotoxin in more distal parts of the small intestine, resulting in damage of the intestinal barrier (Osselaere et al, 2013a).…”

Section: Deoxynivalenolmentioning

confidence: 99%

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Escrivá

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Manyes

2015

Food and Chemical Toxicology

310

203

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Section: Deoxynivalenolmentioning

confidence: 99%

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Escrivá

Font

Manyes

2015

Food and Chemical Toxicology

310

203

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“…In both chicken (Osselaere et al 2013) and turkey (Devreese et al 2015) the DON absorption was low as reflected by the AUC po,plasma, norm = 0.03 l (h*kg) -1 . On the contrary, the absorption appears to be higher in piglets (Prelusky et al 1988) and pigs (Goyarts & Dänicke 2006) as shown by AUC po,plasma,norm = 4.4 and 2.3 l (h*kg) -1 , respectively.…”

Section: Toxicokinetics Of Donmentioning

confidence: 99%

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

Bernhoft

Høgåsen

Rosenlund

et al. 2017

Food Additives & Contaminants: Part A

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Post-smolt Atlantic salmon (Salmo salar) were fed standard feed with added 2 or 6 mg kg -1 pure deoxynivalenol (DON), 0.8 or 2.4 mg kg -1 pure ochratoxin A (OTA), or no added toxins for up to 8 weeks. The experiments were performed in duplicate tanks with 25 fish each per diet group, and the feed was given for three 2-h periods per day. After 3, 6 and 8 weeks, 10 fish from each diet group were sampled. In the following hours after the last feeding at 8 weeks, toxin elimination was studied by sampling three fish per diet group at five time points. Analysis of DON and OTA in fish tissues and plasma was conducted by liquid chromatography-mass spectrometry and high-pressure liquid chromatography with fluorescence detection, respectively. DON was distributed to the liver, kidney, plasma, muscle, skin and brain, and the concentrations in liver and muscle increased significantly from 3 to 8 weeks of exposure to the high-DON diet. After the last feeding at 8 weeks, DON concentration in liver reached a maximum at 1 h and decreased thereafter with a half-life (t 1/2 ) of 6.2 h. DON concentration in muscle reached a maximum at 6 h and was then eliminated with a t 1/2 = 16.5 h. OTA was mainly found in liver and kidney, and the concentration in liver decreased significantly from 3 to 8 weeks in the high-OTA group. OTA was eliminated faster than DON from various tissues. By using Norwegian food consumption data and kinetic findings in this study, we predicted the human exposure to DON and OTA from fish products through carryover from the feed. Following a comparison with tolerable daily intakes, we found the risk to human health from the consumption of salmon-fed diets containing maximum recommended levels of these toxins to be negligible. ARTICLE HISTORY

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“…In this study, we only analyzed the deviation of F based on the two-compartment model. As a result, 10 data sets, 2 of which were original data from published literature [6] and 8 of which were transformed from the plasma concentration-time graphs [5,[7][8][9][10][11][12], met the preconditions and were further analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…They all were described as having the two-compartment model, and used the actually measured drug concentrations. Regarding experimental subjects, one study used broiler chickens [11], one used Sprague-Dawley rats [12], and the rest used human subjects. All of the studies used oral administration as the ev administration method, except for one that used inhalation [7].…”

Section: Methodsmentioning

confidence: 99%

Modifications of the Method for Calculating Absolute Drug Bioavailability

et al. 2016

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-Purpose: Absolute bioavailability (F) is calculated as the ratio of the area under the plasma drug concentration-time curve (AUC) between extravascular administration and intravenous injection. However, as distribution of a drug after intravenous administration does not reach an equilibrium in the body during the distribution phase, the plasma drug concentration at this phase does not reflect the total amount of drug in the body. The goal of this paper was to analyze the insufficiencies of the method for calculating on absolute bioavailability and to propose a modification to improve the calculation. Methods: Literature reporting absolute bioavailability published during 1983-2014 was searched for ten drug candidates. Plasma drug concentrations representing the amount of drug in the body were then calculated at each time point during the distribution phase according to the plasma drug concentration-time relationship during the elimination phase. Results: The AUC values based on the distribution equilibrium drug concentrations following intravenous injection were 75%±11% of the actually measured drug concentrations in the literature. The absolute bioavailability values in the literature were 76%±12% of the actual bioavailability based on the AUCs from distribution-equilibrium drug concentrations. Conclusions: The present method underestimates the absolute drug bioavailability and should be modified to represent the data more accurately.

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Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

Cited by 86 publications

References 27 publications

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Tissue distribution and elimination of deoxynivalenol and ochratoxin A in dietary-exposed Atlantic salmon (Salmo salar)

Modifications of the Method for Calculating Absolute Drug Bioavailability

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