Toxicokinetics and bioaccumulation of silver sulfide nanoparticles in benthic invertebrates in an indoor stream mesocosm

Silva, Patrícia V.; Silva, Ana Rita R.; Clark, Nathaniel J.; Vassallo, Joanne; Baccaro, Marta; Medvešček, Neja; Grgić, Magdalena; Ferreira, Abel L.G.; Busquets-Fité, Martí; Jurkschat, Kerstin; Papadiamantis, Anastasios G.; Puntes, Víctor F.; Lynch, Iseult; Svendsen, Claus; Brink, N.W. van den; Handy, Richard D.; Gestel, C.A.M. van; Loureiro, Susana

doi:10.1016/j.scitotenv.2023.162160

Cited by 5 publications

(1 citation statement)

References 92 publications

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“…Ecotoxicity exposures conducted in soil and mesocosm experiments are often complex with multiple parameters and endpoints (e.g., [37][38][39][40]). The diversity of data types required to monitor soil, porewater, nanomaterials and organisms requires many sample collections and analyses, as well as ensuring collection of pre-experiment data and metadata.…”

Section: Monitoring Nanomaterials Transformation In Complex Environme...mentioning

confidence: 99%

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

Punz,

Brajnik,

Dokler

et al. 2024

Preprint

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Nanosafety assessment, which seeks to evaluate the risks from exposure to nanoscale materials, spans materials synthesis and characterisation, exposure science, toxicology, and computational approaches, resulting in complex experimental workflows and diverse data types. Managing the data flows, with a focus on provenance (who generated the data, for what purpose) and quality (how the data was generated, using which protocol, with which controls), as part of good research output management, is necessary to maximise the re-use potential and value of the data. The concept of Instance Maps has been developed and evolved to visualise experimental nanosafety workflows and to bridge the gap between the theoretical principles of FAIR (Findable, Accessible, Interoperable and Re-usable) data and the everyday practice of experimental researchers. While Instance Maps can be created for completed studies or publications, they are most effective when applied at the study design stage to associate the workflow with the nanomaterials, environmental conditions, method descriptions, protocols, biological and computational models to be used and the data flows arising from study execution. Application of the Instance Map Tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from assessment of nanomaterials transformations in complex media, and documentation of nanomaterial synthesis, functionalisation and characterisation, to description of the culturing of ecotoxicity model organisms Daphnia magna and their use in acute and chronic standardised tests for nanomaterials ecotoxicity assessment, and visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models. These examples showcase the use of the Instance Map approach for coordination of materials and data flows in complex multi-partner collaborative projects, and to support demonstration case studies. Finally, areas for future development of the Instance Map approach and tool are highlighted.

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Section: Monitoring Nanomaterials Transformation In Complex Environme...mentioning

confidence: 99%

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

Punz,

Brajnik,

Dokler

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Predicting uptake and elimination kinetics of chemicals in invertebrates: A technical note on residual variance modeling

van Lingen,

Saccenti,

Suarez-Diez

et al. 2025

Computational Toxicology

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Trophic transfer of nanomaterials and their effects on high-trophic-level predators

Dang,

Yuan,

Huang

et al. 2023

NanoImpact

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Toxicokinetics and bioaccumulation of silver sulfide nanoparticles in benthic invertebrates in an indoor stream mesocosm

Cited by 5 publications

References 92 publications

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

Predicting uptake and elimination kinetics of chemicals in invertebrates: A technical note on residual variance modeling

Trophic transfer of nanomaterials and their effects on high-trophic-level predators

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