Toxicokinetics and systematic responses of differently sized indium tin oxide (ITO) particles in mice via oropharyngeal aspiration exposure

Qu, Jing; Wang, Jianli; Zhang, Haopeng; Wu, Jialu; Wang, Shile; Zang, Yiteng; Huang, Yuhui; Ma, Ying; Cao, Yuxia; Wu, Dezhen; Zhang, Ting

doi:10.1016/j.envpol.2021.117993

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…In addition, the distributions of indium NPs and indium ions were similar, with strong signals detected at the sites of inflammatory cell infiltration. Although previous studies have suggested that ITO NPs may be involved in renal damage, 22 , 23 this study revealed that ITO NPs, in addition to ionized indium, strongly contribute to the development of renal damage.…”

Section: Discussioncontrasting

confidence: 62%

“…Generally, small-diameter particles reach deeper into the lungs and cause severe lung damage. Several studies in which ITO NPs were administered to animals have revealed that ITO NPs cause lung damage similar to that in indium lung 22 ‑ 24 ; and Qu et al 22 showed that smaller particles require less exposure to cause lung damage than larger particles. In vitro studies using human lung epithelial cells have shown that ITO NPs are absorbed by the cells and cause DNA damage.…”

Section: Introductionmentioning

confidence: 99%

“… 25 , 26 Additionally, when animals are administered ITO NPs, indium is deposited not only in the lungs but also in other organs and can damage distal organs, such as the kidney and liver. 22 , 23 However, few studies have conducted detailed examinations of organs other than lungs.…”

Section: Introductionmentioning

confidence: 99%

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Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats

Matsumura,

Tanaka,

Ogra

et al. 2024

Journal of Occupational Health

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Objectives: We aimed to analyze the subchronic toxicity and tissue distribution of indium after the intratracheal administration of indium-tin oxide nanoparticles (ITO NPs) to the lungs of rats. Methods: Male Wistar rats were administered a single intratracheal dose of 10 or 20 mg In/kg body weight (BW) of ITO NPs. The control rats received only an intratracheal dose of distilled water. A subset of rats was periodically euthanized throughout the study from 1 to 20 weeks after administration. Indium concentrations in the serum, lungs, mediastinal lymph nodes, kidneys, liver, and spleen as well as pathological changes in the lungs and kidneys were determined. Additionally, the distribution of ionic indium and indium NPs in the kidneys was analyzed using laser ablation-inductively coupled plasma mass spectrometry. Results: Indium concentrations in the lungs of the two ITO NP groups gradually decreased over the 20-week observation period. Conversely, the indium concentrations in the mediastinal lymph nodes of the two ITO groups increased and were several hundred times higher than those in the kidneys, spleen, and liver. Pulmonary and renal toxicities were observed histopathologically in both the ITO groups. Both indium NPs and ionic indium were detected in the kidneys and their distributions were similar to the strong indium signals detected at the sites of inflammatory cell infiltration and tubular epithelial cells. Conclusions: Our results demonstrate that intratracheal administration of 10 or 20 mg In/kg body weight of ITO NPs in male rats produces pulmonary and renal toxicities.

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats

Matsumura,

Tanaka,

Ogra

et al. 2024

Journal of Occupational Health

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“…Previous reports using animal models demonstrated that ITO particles resided and injured the lung tissue for weeks or months, and only a small amount of ITO was transferred to other organs [17,18]. There are few reports about the long-term in uence of ITO on humans.…”

Section: Discussionmentioning

confidence: 99%

A case report of an indium lung with progressive emphysema and fibrosis that underwent unilateral lung transplantation 20 years after the end of the exposure

Inoue

Ohkouchi

Chonan

et al. 2022

Preprint

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Background: Indium lung is characterized by interstitial pneumonia and/or emphysema, which occurs in indium-tin oxide (ITO) workers. Indium lung is now known to progress after stopping exposure to ITO, but the long-term influences of ITO remain unclear. Case presentation: A 47-year-old, male never-smoker, who was engaged in an ITO manufacturing process for 8 years. Emphysema was indicated by a medical check-up for ex-ITO workers, and the subject was diagnosed with indium lung. He underwent partial lung resections for pneumothorax twice, and obstructive pulmonary dysfunction progressed over the years. The subject underwent right single lung transplantation 20 years after ITO exposure. Pathologically, his lung showed severe distal acinar emphysema and honeycomb change. Fibrosis and destruction of the lung tissue significantly progressed compared to the previous partial resections. Scanning electron microscopy combined with energy dispersive spectroscopy revealed that the deposited particles contained indium and tin. After transplantation, his respiratory function was improved. Conclusions: In this case, ITO resided in the lung tissue for 20 years, and lung tissue destruction continued to progress. Careful medical follow-up is recommended for ITO workers even if they are asymptomatic.

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“…Nevertheless, because the surface of ITO is characterised by strong water absorption, it can easily form 'mildew' on reacting with water and carbon dioxide in the air; thus, a thin layer of chemically stable Au is normally coated onto the surface of ITO as a protective layer to protect it from moisture in the air. In contrast, as a kind of III-V semiconductor oxide [12], ITO can stop the resonances of Ag and Au from affecting each other if the three materials form the sandwich structure shown in Figure 1. Owing to the good conductivity of ITO, the resonance SPWs formed at the interface can be quickly transmitted outward.…”

Section: Introductionmentioning

confidence: 99%

Performance Analysis of a Kretschmann-Based Ag-ITO-Au Surface Plasmon Resonance Sensor through Numerical Simulations

Zhang

et al. 2021

International Journal of Optics

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Variations of a Kretschmann-structure-based Ag-indium tin oxide- (ITO-) Au surface plasmon resonance (SPR) sensor were explored to improve its sensitivity. The sensor structure was optimised, and its characteristics were studied through numerical simulations. The chip structure that comprised 20 nm Ag/30 nm ITO/10 nm Au yielded the best sensing performance, wherein the angular sensitivity could reach 197.6° RIU−1 and the figure of merit was 43.4 RIU−1. These performance parameters are nearly three times higher than those of Ag/Au bimetallic resonance sensors. Furthermore, an adhesive Cr layer and two-dimensional graphene were incorporated into this sensor structure to explore their impact on the performance. The results demonstrated that the Cr layer significantly weakened the sensor performance, whereas graphene did not produce the expected enhancement effect on this structure. If simply adding a layer to a Au/Ag sensor can produce a three-fold improvement in its performance, then its economic and scientific benefits are potentially significant and widespread.

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Toxicokinetics and systematic responses of differently sized indium tin oxide (ITO) particles in mice via oropharyngeal aspiration exposure

Cited by 11 publications

References 46 publications

Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats

Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats

A case report of an indium lung with progressive emphysema and fibrosis that underwent unilateral lung transplantation 20 years after the end of the exposure

Performance Analysis of a Kretschmann-Based Ag-ITO-Au Surface Plasmon Resonance Sensor through Numerical Simulations

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