2003
DOI: 10.1289/ehp.6114
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Toxicologic and epidemiologic clues from the characterization of the 1952 London smog fine particulate matter in archival autopsy lung tissues.

Abstract: Exposure to atmospheric fine particulate matter (PM), even at low ambient concentrations, has clearly been linked to increases in mortality and morbidity. A 10- micro g m(-3) increase in PM10 (PM < 10 micro m) has been found to produce a 0.5% increase in daily mortality. The mechanism of action is a source of debate, although recent attention has focused on the cardiac effects of PM exposures. Likewise, several possible etiologic agents have been implicated, including ultrafine PM (PM Show more

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Cited by 94 publications
(62 citation statements)
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“…Patients with Chronic Pulmonary Diseases (COPD) for example, tend to show exacerbated health conditions upon exposure to elevated short-term UFP-concentrations (Arbex et al, 2009). This is consistent with epidemiological observations of Hunt et al (2003) and Stenfors (2004) who showed that even a small increase in UFP concentrations may cause significant health effects.…”
Section: Introductionsupporting
confidence: 76%
“…Patients with Chronic Pulmonary Diseases (COPD) for example, tend to show exacerbated health conditions upon exposure to elevated short-term UFP-concentrations (Arbex et al, 2009). This is consistent with epidemiological observations of Hunt et al (2003) and Stenfors (2004) who showed that even a small increase in UFP concentrations may cause significant health effects.…”
Section: Introductionsupporting
confidence: 76%
“…Using electron microscopy analysis they revealed a predominance of retained soot and metal-bearing particles. Based on the experimental data, they stated that exposure to atmospheric particulate matter, even at low concentrations, is clearly linked to increased mortality and morbidity 22 . Phillips et al analyzed autopsy samples of a patient operating a metal arc process for spraying nickel onto bearings who died of respiratory failure 13 days after exposure.…”
Section: Discussionmentioning
confidence: 99%
“…166 Lack of accessibility of fresh tissue makes postmortem tissue an important alternative. Postmortem tissue has been used for studies on morphology [167][168][169][170][171] ; to study the mechanical properties of different organs 167,168 ; to validate new techniques [172][173][174] ; to correlate morphology with microbiology findings 103 ; to report new or rare diseases 175 ; to study the molecular mechanisms 95,123 to determine toxic element exposure 87 ; to determine a definitive disease diagnosis 88,96,104,176 ; and to detect infectious agents. 10,68 The use of postmortem tissue is often hampered, however, by agonal factors, postmortem intervals (PMIs), and storage conditions that contribute to tissue degradation.…”
Section: Sources and Types Of Solid Tissues Collectedmentioning
confidence: 99%