1969
DOI: 10.1016/0041-008x(69)90018-0
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Toxicologic and pharmacologic evaluation of phleomycin including special studies on its nephrotoxicity

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Cited by 39 publications
(35 citation statements)
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“…To address these questions, we first studied the expressions of AdipoR1 and -R2 during fasting and refeeding. We also analyzed the expressions of AdipoR1/R2 in an insulin deficiency model by streptozotocin (STZ) treatment (18). Moreover, we studied these expressions in a hyperinsulinemia model because of obesity-linked insulin resistance.…”
mentioning
confidence: 99%
“…To address these questions, we first studied the expressions of AdipoR1 and -R2 during fasting and refeeding. We also analyzed the expressions of AdipoR1/R2 in an insulin deficiency model by streptozotocin (STZ) treatment (18). Moreover, we studied these expressions in a hyperinsulinemia model because of obesity-linked insulin resistance.…”
mentioning
confidence: 99%
“…STZ has been used as a diabetogenic agent in rats and other animals. 18,19 STZ causes DNA strand breaks in pancreatic islets and stimulates nuclear poly (ADP-ribose) synthetase, and thus depletes the intracellular NAD and NADP levels. NAD depletion by STZ inhibits proinsulin synthesis and thus induces diabetes.…”
Section: Discussionmentioning
confidence: 99%
“…The most commonly used drug for this induction is Streptozotocin (STZ) because of its toxic effects on islet beta cells (Fadillioglu et al, 2008). (Rakieten et al, 1963; Ar'Rajab and Ahrén 1993; Gu et al, 1997). Co-morbid diseases with hyperglycaemia include high cholesterol, loss of body weight, loss of appetite etc.…”
Section: Issn: 2320-5407mentioning
confidence: 99%