Ergot Alkaloids and Related Compounds 1978
DOI: 10.1007/978-3-642-66775-6_12
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Toxicologic Considerations

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Cited by 32 publications
(38 citation statements)
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“…In dogs, a variety of hypertensive vasoconstrictor agents (Table 2) can also elicit characteristic arterial changes in the heart, as well as other organs (6,14,51). Intense vasoconstriction may be the principle cause of medial necrosis of coronary arteries of dogs treated with excessive doses of digoxin (6,48).…”
Section: Vasoactive Induced Arterial Lesions In the Dogmentioning
confidence: 99%
“…In dogs, a variety of hypertensive vasoconstrictor agents (Table 2) can also elicit characteristic arterial changes in the heart, as well as other organs (6,14,51). Intense vasoconstriction may be the principle cause of medial necrosis of coronary arteries of dogs treated with excessive doses of digoxin (6,48).…”
Section: Vasoactive Induced Arterial Lesions In the Dogmentioning
confidence: 99%
“…Because of large species-specific differences in the relative toxicities of different ergot alkaloids administered by various means to laboratory animals (Griffith et al 1978), it is not possible to extrapolate directly from these data to obtain toxicity estimates of ergot-contaminated poultry feeds. Controlled studies to determine relative toxicity levels of the various alkaloids commonly found in Canadian ergot sclerotia are required before the safety of a particular feed sample can be assessed.…”
mentioning
confidence: 99%
“…For example, in subacute and chronic toxicity studies the occurrence of gangrene in various animal species correlated closely with the vasoconstrictor potential (9). In this case, human intoxication is indeed well predictable from animal experiments.…”
Section: : Ergotaminementioning
confidence: 83%
“…In standard reproduction toxicological studies in pregnant mice, rats and rabbits it was found that high oral doses given during the organogenetic phase affected the maternal weight gain and caused an increase in prenatal mortality as well as evidence of fetal retardation and anomalies in rats (9). This result was observed at about the time of the thalidomide tragedy and caused considerable concern, because the majority of patients using ergotamine preparations are women.…”
Section: : Ergotaminementioning
confidence: 99%