Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks

Abstract

The present study shows that C. adamantium extract has anti-inflammatory, antihyperalgesic, and antidepressive properties in rodents without causing toxicity.

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

“…Some studies showed the anti-inflammatory properties of extracts of Campomanesia velutina and Campomanesia adamantium leaves [3,4]. The extracts of C. adamantium fruit bark also exhibited antihyperalgesic, antidepressant, and anti-inflammatory effects in experimental models in rodents [5].…”

Campomanesia adamantium extract induces DNA damage, apoptosis, and affects cyclophosphamide metabolism

“…C. adamantium is a common species in Brazilian cerrado, and its anti-inflammatory, antidiarrheal, antiseptic, and antioxidant activities, reported by the native population, have been confirmed in previous studies (Ramos et al, 2007;Coutinho et al, 2008;Pascoal et al, 2011;Ferreira et al, 2013;de Souza et al, 2014). However, few studies on its mutagenic potential have been reported.…”

“…Doses were selected based on doses reported in studies by Fernandes and Vargas (2003) and de Souza et al (2014).…”

“…The fruit is commonly known as guavira, gabiroba, or guabiroba, and appears from September to December (Avidos and Ferreira, 2000). Species belonging to the Campomanesia genus have been shown to have medicinal properties, such as anti-inflammatory, antidiarrheal, antiseptic (Rodrigues and Carvalho, 2001;Brandelli et al, 2011;de Souza et al, 2014), and antioxidant activities (Ramos et al, 2007;Coutinho et al, 2008;Rufino et al, 2010;Pascoal et al, 2011), which are mainly attributed to the presence of phenolic compounds, flavonoids, chalcones, carotenoids, and vitamins.…”

First comprehensive study on total determination of nutritional elements in the fruit of the Campomanesia adamantium (Cambess.): Brazilian cerrado plant

“…In previous studies in vitro, the fruit extracts of C. adamantium were evaluated against the microorganism Mycobacterium tuberculosis [16]. Moreover, studies in animals showed that the fruit extracts of C. adamantium has anti-inflammatory, antihyperalgesic, and antidepressive properties in rodents without causing toxicity [17]. In the traditional medicine in Brazil, the root and leaves of Campomanesia adamantium O. Berg are used for antidiabetic effects.…”