Toxicological and Antibacterial Studies of Mixed Amodiaquine-Anthranilic Acid Metal-Drug Complexes: Synthesis and Characterization

Abstract

Background:The use of metal-drug complexes in medicine has encouraged researchers in the quest for novel chemotherapeutic agents against toxicity, bacterial and other infections. Methods: Four new mixed metal-drug complexes of amodiaquine and anthranilic acid have been prepared using Ni(II), Cd(II), Mn(II), and Cu(II) metal ions. The synthesized complexes were characterized by physicochemical and spectroscopic techniques such as melting point, elemental analysis, molar conductance, magnetic moment, AAS, FT-IR, and electronic spectroscopy. Results: The IR spectra revealed that in amodiaquine, coordination occurred through the nitrogen of the amino and oxygen of hydroxyl groups, and the oxygen of the carbonyl and nitrogen of the amino groups in anthranilic acid. Antibacterial assay of the complexes exhibited better activities than the free ligands against selected organisms. [Mn(ANT)(AMO)Cl 2 ] displayed the highest antibacterial activity against B. subtilis strains at a concentration of 30 µg/ml with a zone of inhibition of 48 mm. The toxicological effect of the compounds in serum and liver homogenate of albino rats (Rattus novergicuss) was investigated.Conclusion: Alkaline phosphate (ALP) concentrations for the metal complexes in the liver and serum homogenates were significantly different when compared to the control group after the study period at (P< 0.05). The antibacterial assay of the complexes showed better activities than the free ligands, indicating them to be potential chemotherapeutic agents.