Toxicological and Teratological Studies of a Rapeseed Protein Diet in Rats and Mice

Sharpe, George; Larsson, Karin; Liedén, S.-Å.

doi:10.1159/000175602

Cited by 14 publications

(5 citation statements)

References 3 publications

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“…However, the occurrence of serious complications during late pregnancy in rats fed on RPC essentially free from glucosinolates has been reported in previous papers (4)(5)(6)(7). Since it contains a rather high amount of phytic acid RPC may interfere with the utilization of dietary minerals, e.g.…”

Section: Introductionmentioning

confidence: 85%

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Eklúnd

Ågren²

1978

Ann Nutr Metab

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In order to study the effects of a dietary rapeseed protein concentrate (RPC) on tocopherol and zinc levels in serum, liver and tibia, female rats were fed a tocopherol-reduced diet for a 3-week period and were then transferred to either of a RPC diet or a control diet containing casein at 20% levels of protein. No unfavourable effects on food intakes or weight gains were recorded. The serum zinc content of the RPC group was slightly reduced and the serum tocopherol values significantly lowered in comparison to the control group. Zinc and tocopherol contents of the livers were not changed. Precipitation of sera by dextran sulphate in the presence of calcium ions indicated a reduced level of low density lipoproteins in rats fed RPC diet. In a second experiment, male and female rats were fed diets containing 10% of protein derived either from RPC or casein. Low zinc contents of tibiae indicated a low biological availability of the zinc present in the RPC diet. Rats on RPC diet also showed reduced levels of tocopherol in serum. Despite a lowered zinc status in rats fed RPC diet there was no reduction in food intake, weight gain or growth of tibia in these groups.

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Section: Introductionmentioning

confidence: 85%

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Eklúnd

Ågren²

1978

Ann Nutr Metab

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“…It has, therefore, been recommended that not more than 15 % of rapeseed meal from conventional varieties be included in the feed of starting and growing chickens (7). It has been reported that even protein concentrates prepared from conven tional rapeseed exhibit some toxic effects in experimental animals (12). Thus, it is obvious that the breeding of new varieties of rapeseed, which contain low levels of glucosinolates, as well as the production of protein isolates from vari eties of rapeseed containing high or low levels of glucosinolates, constitute major steps towards better utilization of rapeseed protein.…”

Section: Methodsmentioning

confidence: 99%

Nutritive Value of Rapeseed Meals and Rapeseed Protein Isolates

Nockrashy¹,

Kiewitt²,

Mangold³

et al. 1975

Ann Nutr Metab

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Defatted meals of two new varieties of rapeseed, Brassica napus, Erglu and Lesira, and protein isolates prepared therefrom, were fed to chicks that had been depleted of their embryonic protein reserve. First, the animals were fed at a 12 % protein level, half of it from rapeseed meal, or a rapeseed protein isolate and, subsequently, at a 20 % level, all of it from rapeseed products. Feed consumption, weight gain and protein efficiency ratio revealed better performance of the protein isolates as compared to the corresponding meals. This is attributed to the favorable amino acid patterns of these isolates and the absence of glucosinolates. Erglu meal, too, is eminently suitable as a supplement to chicken feed, whereas Lesira meal, although its amino acid pattern is adequate and similar to that of Erglu meal, showed detrimental effects, probably due to its high glucosinolate content.

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“…Feeding rapeseed protein concentrates is associated with specific problems of anorexia, weight loss and reduction in number of live pups at parturition [33]. These problems occur with low glucosinolate protein concentrates and cannot be reproduced by feeding glucosinolates [59]. Extensive work in Sweden has shown that the active principle is a low molecular weight, water soluble component [33] which may be associated with disruption of vitamin E absorption and function [14], since deficiency of this vitamin is known to depress reproductive performance.…”

Section: Ruts and Micesmentioning

confidence: 99%

Rapeseed meal‐glucosinolates and their antinutritional effects Part 5. Animal reproduction

Mawson

Heaney

Zduńczyk

et al. 1994

Nahrung

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Although there is no clear evidence to fully describe the mechanism involved in glucosinolate-related effects on animal reproduction, lowered fertility in animals fed diets with rapeseed meal (RSM) inclusion is related to glucosinolate content in the diet. Negative effects can result both from multidirectional action of glucosinolates, malnutrition of mother due to the thyroid dysfunction, transfer of goitrogenic compounds to foetus and reduced transfer of nutritive compounds (e.g. iodine) through the placenta. The degree of reproduction impairment depends both on glucosinolate content and on the type of animal. Pregnant female rats are sensitive to the presence of glucosinolates, and the first symptoms of fertility impairment and lowering of offspring survival rate may occur at low glucosinolate levels, e.g. with diets containing low glucosinolate rapeseed meal (LG-RSM). In the case of swine, the limiting value above which sows fertility may be impaired is 4 mumol of total glucosinolates per g diet and 8 mmol of daily intake of these compounds. Opinions on the permitted RSM inclusion in diet for hens are very divergent. Some authors recommend limiting of the RSM inclusion to 10%, while others did not find any lowering of egg production in hens fed with two- or three-fold greater RSM inclusion rates. Most long-term experiments with heifers, cows and ewes indicate that ruminants tolerate the level of glucosinolate in LG-RSM although feeding this fodder as the only high-protein concentrate component may lead to impaired fertility.

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Toxicological and Teratological Studies of a Rapeseed Protein Diet in Rats and Mice

Cited by 14 publications

References 3 publications

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Effect of a Dietary Rapeseed Protein Concentrate on the Contents of α-Tocopherol and Zinc in Serum, Liver and Tibia of Rats

Nutritive Value of Rapeseed Meals and Rapeseed Protein Isolates

Rapeseed meal‐glucosinolates and their antinutritional effects Part 5. Animal reproduction

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