Toxicological, Antidiarrheal and Spasmolytic Activities of Solanum paniculatum

Clementino-Neto, José; Pereira, Joedna Cavalcante; Vasconcelos, Luiz Henrique César; Souza, Iara Leão Luna de; Silva, Anne D. S.; Silva, Telma M. G.; Ramos, Natalia S. M.; Pêssoa, Hilzeth L. F.; Silva, Tania M. S.; Silva, Bagnólia A. da; Cavalcante, Fabiana de Andrade

doi:10.1055/s-0035-1557831

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Solanum paniculatum L., popularly known in Brazil as jurubeba, is a native plant species from South America with several uses in the culinary area and folk medicine. 1 Studies of the benefits of jurubeba have been compiled by European naturalists since the 19th century, including the famous German botanist C. F. P. von Martius. 2 Preparations using roots and stems are indicated for the treatment of liver and digestive disorders.…”

Section: Introductionmentioning

confidence: 99%

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

Gazolla

Marques

Silva

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Solanum paniculatum L., popularly known as jurubeba, has traditionally been used in Brazilian folk medicine for liver diseases. However, there is a lack of knowledge about the chemical characterization of 3‐aminospirostane alkaloids, an important class related to pharmacological activities. This work aimed to characterize the alkaloids using liquid chromatography with tandem mass spectrometry (LC/MS/MS) supported by molecular networking and theoretical calculations as well as to evaluate the contribution to hepatoprotective activity. Methods S. paniculatum roots were collected and macerated with MeOH/H2O (8:2) obtaining the crude extract (SP‐CE). From this, partition using EtOAc with pH variation yielded the alkaloidic fraction (SP‐AF). Both were evaluated in an acute liver injury model (100 and 200 mg/kg), after intraperitoneal administration of carbon tetrachloride (CCl4) in mice. AST (aspartate transaminase) and ALT (alanine transaminase) serum levels were investigated, as well as the histopathological characteristics. The SP‐CE and SP‐AF were analyzed by LC/MS/MS, using quadrupole/time‐of‐flight and ion‐trap systems. The alkaloids annotated by the GNPS molecular network had their structures defined using gas‐phase ionization and fragmentation reaction supported by theoretical calculations. Results The SP‐CE and SP‐AF decreased the ALT serum levels compared with the negative control. The group treated with the SP‐CE (at the highest dose) demonstrated a significant decrease of ALT. Hepatic cell degeneration decrease was observed mainly at the highest dose of the treatment. Detailed electrospray ionization MS/MS data allowed us to identify alkaloids not previously reported, to propose their gas‐phase reactions and to redefine the initial open ring fragmentation mechanism of the steroidal alkaloids with the jurubidine moiety. Conclusions The results allowed us to identify seven steroidal alkaloids from jurubeba and redefine the initial mechanism of fragmentation. A significant hepatoprotective effect was also demonstrated, corroborating its traditional use.

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Section: Introductionmentioning

confidence: 99%

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

Gazolla

Marques

Silva

et al. 2020

Rapid Comm Mass Spectrometry

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“…Baseado no fato de que diversas espécies de Solanum já apresentaram atividade espasmolítica sobre o músculo liso (OLIVEIRA et al, 2006a,b;PARMAR;GANGWAL;SHETH, 2010;MONTEIRO et al, 2012;CORREIA, 2009;CAVALCANTE et al, 2013;CLEMENTINO-NETO et al, 2015) e que Santos et al (2003) demonstraram que o extrato obtido do caule de Solanum stipulaceum apresenta efeito espasmolítico, resolveu-se investigar se o extrato obtido das partes aéreas desta espécie também apresentaria esta atividade.…”

Section: Resultsunclassified

Análise Da Rotulagem De Produtos Cosméticos Comercializados Em Salões De Beleza Na Cidade De Santa Cruz Do Capibaribe – Pe

Silva¹,

Silva²,

Vasconcelos³

2021

Fármacos, Medicamentos, Cosméticos E Produtos Biotecnológicos

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Direitos para esta edição cedidos à Atena Editora pelos autores.Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons.Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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“…Elephant apple ( D. indica ) is a prominent species which contains chemical substances that can be applied for medicinal purposes, such as β‐sitosterol and stigmasterol for their antimicrobial activity (Dey, Mukherjee, De, & Pandey, ; Ododo, Choudhury, & Dekebo, ), as well as vitamin E for its antioxidant features (Muhit, Tareq, Apu, Basak, & Lslam, ; Yeshwante et al, ). These four components also have anti‐inflammatory (Parvin et al, ) and antidiarrheal properties (Clementino‐Neto et al, ; Singh & Gupta, ). The methanolic crude extract showed that the leaves provide a rich source of triterpenoids and flavonoids (Abreu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Screening of phytochemicals and toxicity of medicinal plants,Dilleniaspecies, reveals potential natural product resources

Thooptianrat

Chaveerach

Sudmoon

et al. 2017

Journal of Food Biochemistry

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Plants in genus Dillenia have traditionally been consumed as foods and used for cancer and diarrhea treatments. Crude hexane extracts of nine species, D. aurea, D. excelsa, D. grandifolia, D. ovata, D. parviflora, D. philippinensis, D. pulchella, D. reticulata, and D. suffruticosa were analyzed for chemical contents via gas chromatography‐mass spectrometry, and for their cytotoxicity and genotoxicity on leukocytes via cell counting and comet assays. Oleamide, a chemopreventive agent which acts against Alzheimer's disease, enhances memory function and promotes sleep, was found at the highest amount (18.05–75.60%). The other components discovered in high amounts were squalene and vitamin E. The IC50 of all studied species was higher than 430 µg/mL. Comet assay indicated insignificant DNA damage (p > .05). These results indicate that the plants containing a high amount of useful phytochemicals are nontoxic to normal human cells, thus may be safely applied for the treatment of Alzheimer's disease and other related conditions. Practical applications Oleamide has an important role in living things, especially in humans. Its functions are, improved memory recovery, induced deep sleep and appetite in elders. Based on the principles of phytotherapy, a plant species actually contains several pharmacological compounds in a different quantity; a medicinal reading should be in a single unit. In agreement with a high quantity of oleamide in Dillenia species, many species would be selected to produce natural products in convenient forms, and in drug discovery, because this serves as active principles in drugs as well as templates for synthesis of new drugs. In this research, seven out of nine species including Dillenia aurea, D. excelsa, D. grandifolia, D. ovata, D. parviflora, D. philippinensis, and D. reticulata contained high amounts of oleamide, were expected to release single medicinal activity, and show no cytotoxicity and genotoxicity. Accordingly, they should effectively be made available in modified forms in order to be health products.

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Toxicological, Antidiarrheal and Spasmolytic Activities of Solanum paniculatum

Cited by 6 publications

References 22 publications

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

Análise Da Rotulagem De Produtos Cosméticos Comercializados Em Salões De Beleza Na Cidade De Santa Cruz Do Capibaribe – Pe

Screening of phytochemicals and toxicity of medicinal plants,Dilleniaspecies, reveals potential natural product resources

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