2014
DOI: 10.1016/j.yrtph.2013.12.011
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Toxicological assessment of enzyme-treated asparagus extract in rat acute and subchronic oral toxicity studies and genotoxicity tests

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Cited by 22 publications
(15 citation statements)
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“…Akt signaling is a master regulator for cellular proliferation, survival, and energy metabolism [ 22 ]. A previous study demonstrated that oral acute and subacute ETAS 50 administration has no significant side effects on food consumption, body weight, mortality, urinalysis, hematology, biochemistry, necropsy, organ weight, and histopathology in rats [ 23 ]. The lack of side effects may be due to ETAS 50 having minimal influence on basal Akt phosphorylation.…”
Section: Resultsmentioning
confidence: 99%
“…Akt signaling is a master regulator for cellular proliferation, survival, and energy metabolism [ 22 ]. A previous study demonstrated that oral acute and subacute ETAS 50 administration has no significant side effects on food consumption, body weight, mortality, urinalysis, hematology, biochemistry, necropsy, organ weight, and histopathology in rats [ 23 ]. The lack of side effects may be due to ETAS 50 having minimal influence on basal Akt phosphorylation.…”
Section: Resultsmentioning
confidence: 99%
“…Other investigators have reported that ETAS shows neuroprotective effects in vitro and attenuates cognitive impairment in senescence-accelerated mice (17). Several toxicity studies of ETAS have also been conducted with no abnormal results in the Ames test, a bone-marrow micronucleus assay in mice, and both acute and subchronic oral dose toxicity studies in rats (18). We report here the results of two human studies designed to determine whether ETAS affects HSP70 expression in blood, modulates the autonomic nervous system and stress-related hormone levels, and alters the sleep state.…”
Section: Effects Of Enzyme-treated Asparagus Extract On Heat Shock Prmentioning
confidence: 99%
“…ETAS induces Hsp70 and heme oxygenase-1 mRNAs in neuroblastoma cells, showing cytoprotective effects [7]. A toxicological assessment of ETAS in rats [8] has supported its safety as a food and dietary supplement. Furthermore, ETAS attenuates the cognitive impairment of senescence-accelerated mouse prone 8 (SAMP8) mice, in which contextual fear memory (considered as a hippocampus-dependent memory) is significantly impaired [7].…”
mentioning
confidence: 99%