Toxicological Characteristic of Designer Drugs From the Group of Synthetic Opioids

Background: Poisoning with psychotropic and narcotic substances is still leads to the general structure of fatal intoxications. A decreased traditional psychotropic and narcotic drug fatal poisoning and an increased new synthetic psychoactive substances and combined consumption are recorded in the country. Aims: This study aimed to study the dynamics of drug poisoning incidence according to the annual report data in 20172020 in the Krasnodar territory and establish their predominant etiology. Analyze the medical literature and identify the data mostly described during the external examination that suggests narcotic drug exposure possibility of the body. Comparison of the literature and external examination results of the corpse from the Expert Conclusions (Acts of forensic medical research) to further use the signs to create a profile of the suspected poisoned corpse with narcotic substances. Material and methods: The study material includes the annual reports of the State Budgetary Healthcare Institution Bureau SME of the Ministry of Health of the Krasnodar Territory in 20172020, archival medical documentation autopsy reports in cases of death from narcotic substances; domestic and foreign literary sources. Results: In the Krasnodar Territory, opiates account for a large proportion of drug deaths. Psychotropic and narcotic drug intake is often (up to 30%) combined with alcohol consumption. The study showed that forensic pathology rarely uses external signs that make up the profile of a corpse suspected of drug poisoning at the initial stage. The most common signs (in 50% of cases) were: injection traces, cyanotic and flushed face, conjunctival hemorrhages, and whitish-pink foam in the nose or mouth openings. Others were not given due attention. Conclusion: The research topic dictates the need for further study and problem development, accumulation, and systematization of the obtained material for subsequent use.

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External study possibilities of a dead body solution about the death occurrence from psychotropic and narcotic drug poisoning

Травенко

Николаевна²,

Породенко

2021

Russian Journal of Forensic Medicine

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Dental Status and Features of Dental Care in Drug-Dependent Patients Taking Synthetic Narcotic Substances

Gigolaev

Khabadze

Zoryan

et al. 2022

Actual Problems in Dentistry

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The subject. Clinical manifestations of dependence on synthetic narcotic substances have been thoroughly studied by specialists in the field of psychiatry, narcology, therapy, immunology at the tissue, organ and system levels. Unfortunately, the same cannot be said about dentistry. When receiving a drug-dependent patient, most dentists cannot determine drug addiction and, accordingly, competently draw up a treatment plan for such patients. Objectives. To study the features of the management of dental diseases in patients taking synthetic narcotic substances, according to the literature. Methodology. Within the framework of this article, the analysis of publications from the databases PubMed, Google Scholar, eLibrary and Cyberleninka describing the toxicological properties and clinical manifestations of synthetic narcotic substances is carried out. The search included full-text articles for the last 5 years. Informational letters were excluded from the analysis. Results. The fight against the spread and use of narcotic substances throughout the world is not slowing down. However, the creation of analogues of studied and illicit drugs by correcting their chemical structures, as well as new narcotic substances with known properties, reduces the effectiveness of this struggle. The dental status of patients taking synthetic narcotic substances has been little studied, since they rarely seek dental care, arriving, as a rule, for urgent indications, or by referral from a narcological institution. Conclusions. The analyzed literature data suggest that in patients taking synthetic "designer" substances, the most studied are the manifestations of drug addiction in terms of their effect on the central nervous system. This problem is relevant for doctors of narrow specialties, since knowing the signs of drug use, it is possible to correctly plan treatment tactics, preventing the occurrence of complications during the administration of drugs. Since the manifestations of drug addiction in dental patients are practically not described in the scientific literature, this topic requires further research.

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Dynamics of acute poisoning with narcotic and psychotropic drugs in children

Kutsenko

Kovaleva

Mironova

et al. 2021

RPJ

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Introduction. Acute poisoning of chemical aetiology in children and adolescents is a significant medical and social problem. The average overall assessment of the state of the drug situation in St. Petersburg by all criteria is: in 2018 - 3.6 (pre-crisis condition), in 2019 - 3.5 (pre-crisis), in 2020 - 3.3 (severe). The aim of this work is to analyze the structure of acute poisoning with narcotic and psychodysleptic drugs in children of St. Petersburg. Materials and methods. An analysis was carried out of 4256 cases of acute chemical poisoning in children (form No. 64) admitted to the acute poisoning department of N.F. Filatov St. Petersburg State Children Hospital from 2016 to 2018. Results. The total number of chemical aetiology poisonings was 1441 cases in 2016, 1,527 in 2017 and 1,288 in 2018. Poisoning with narcotic and psychodysleptic drugs was (of the total number of poisonings) in 2016 - 3.1%, in 2017 - 5.8% and 2018 - 4.9%. The top place among poisonings with toxic substances of this group are opiates, methadone, LSD, hashish. The maximum poisoning with psychotropic drugs is psychostimulants such as methamphetamine - 2.6%, amphetamine - 1.4%, ecstasy - 1.2%. There was a significant increase in acute poisoning with unspecified psychotropic drugs from 0.7% (2016) to 4.6% (2018). Conclusions. The obtained results of the study revealed a decrease in the total number of acute chemical poisoning by 18.9%. On the background of a reduction in the total number of poisonings, there is an increase in the frequency of poisoning with neurodestructive substances (methadone, hashish, LSD, benzodiazepine, amphetamine, methamphetamine and ecstasy). The most frequent cause of acute chemical intoxication in children is poisoning with psychotropic drugs.

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Toxicological Characteristic of Designer Drugs From the Group of Synthetic Opioids

Cited by 4 publications

References 25 publications

External study possibilities of a dead body solution about the death occurrence from psychotropic and narcotic drug poisoning

External study possibilities of a dead body solution about the death occurrence from psychotropic and narcotic drug poisoning

Dental Status and Features of Dental Care in Drug-Dependent Patients Taking Synthetic Narcotic Substances

Dynamics of acute poisoning with narcotic and psychotropic drugs in children

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