Toxicological consequences of aroclor 1254 ingestion by female rhesus (macaca mulatta) monkeys. Part 1A. Prebreeding phase: Clinical health findings

Arnold, Douglas L.; Bryce, F.; Stapley, R.; McGuire, Peter; Burns, DP; Tanner, Joanna; Karpinski, K.

doi:10.1016/0278-6915(93)90218-n

Cited by 37 publications

(23 citation statements)

References 38 publications

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“…From these studies a LOAEL of 0.005 mag-day was established. This information is supported by Tryphonas et al (1989);(1991a);(1991b);Arnold (1992); Arnold et al (1993a); (1993b); Loo et al (1989);and Luster et al (1992).…”

Section: E2413 Aroclor-1254mentioning

confidence: 74%

“…This Rfl) value was based on studies of Aroclor-1254 ingestion by female Rhesus (Macaca mulatta) monkeys reported by Arnold et al (1993a); (1993b); (1991a);and (1991b). The safety factor consists of a 10-fold factor to account for sensitive individuals, a factor of 10 to account for the use of a LOAEL instead of a NOAEL, and a factor of three to extrapolate from Rhesus monkeys to humans.…”

Section: E2413 Aroclor-1254mentioning

confidence: 99%

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Remedial investigation/feasibility study for the Clinch River/Poplar Creek operable unit. Volume 3. Appendix E

1995

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Section: E2413 Aroclor-1254mentioning

confidence: 74%

Section: E2413 Aroclor-1254mentioning

confidence: 99%

Remedial investigation/feasibility study for the Clinch River/Poplar Creek operable unit. Volume 3. Appendix E

1995

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“…Monkeys exposed to 0.005-0.08 mg/kg b.w. per day Aroclor 1254 for 37 months, showed dose-related ocular and dermal effects (Arnold et al, 1993a). Conjunctivitis was observed in Rhesus monkeys treated in the diet with 0.2 mg/kg b.w.…”

Section: Ocular Effectsmentioning

confidence: 92%

“…per day doses of Aroclor 1254 for up to 72 months (Arnold et al, 1993a(Arnold et al, ,b, 1995(Arnold et al, , 1997. Comparisons between the treated and control groups showed that the conception rates were significantly (p<0.05) reduced at doses of 0.02 mg/kg b.w.…”

Section: Reproductive and Developmental Effectsmentioning

confidence: 99%

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2005

EFSA Journal

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SUMMARYPolychlorinated biphenyls (PCB) cover a group of 209 different PCB congeners which can be divided into two groups according to their toxicological properties. One group, consisting of 12 congeners, show toxicological properties similar to dioxins, is therefore termed "dioxinlike PCB" (DL-PCB), and these have been included in the "Risk Assessment of Dioxins and Dioxin-Like PCBs in Food" performed by the EU Scientific Committee on Food (SCF). The other PCB, referred to as "non dioxin-like PCB" (NDL-PCB), have not been previously evaluated by the SCF or EFSA. Both groups of PCB, NDL-PCB as well DL-PCB, are usually found in feed and food.PCB were widely used in a number of industrial and commercial applications. It is estimated that more than 1 million tons of technical PCB mixtures were produced world-wide since their first commercial use in the late 1920s. Although produced by comparable production processes, technical PCB mixtures contain both DL and NDL-PCB and may vary considerably with respect to their congener composition due to differences in the amount of chlorine and the reaction conditions applied. Moreover, technical PCB mixtures contain other dioxin-like compounds as impurities, such as polychlorinated dibenzofurans (PCDF). The different compositions as well as the presence of toxicologically relevant impurities may have a significant impact on the results of toxicological studies with technical PCB mixtures.Although the manufacture, processing and distribution of PCB has been prohibited in almost all industrial countries since the late 1980s, their entry into the environment still occurs, especially due to improper disposal practices or leaks in electrical equipment and hydraulic systems still in use. PCB are highly persistent and are globally circulated by atmospheric transport and thus are present in all environmental media.Data on the occurrence of NDL-PCB in food and feed have been reported in different ways for example as the sum of three PCB congeners (PCB 138, 153 and 180), as the sum of six PCB congeners (PCB 28, 52, 101, 138, 153, 180) often referred to as indicator PCB or as the sum of seven (sum of six indicator PCB plus PCB 118). This lack of consistency often hampers a direct comparison of occurrence data. The Panel decided to use the sum of the six indicator PCB as the basis for the evaluation in this opinion, because these congeners are appropriate indicators for different PCB patterns in various sample matrices and are most suitable for a risk assessment of NDL-PCB on the basis of the available data. The Panel noted that the sum of the six indicator PCB represents about 50% of total NDL-PCB in food.Following exposure of farm animals, NDL-PCB will accumulate in meat, liver and particularly in fat tissues. In addition, NDL-PCB will be transferred into milk and eggs, and levels in these products will reach a steady state following exposure over a period of several weeks. PCB 138 and 153, both with six chlorine atoms, show the highest carry-over into milk and eggs, in the order of 5...

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“…The reported RjD was used as the most likely value to occur (mode). Therefore, Q log-trinngulnr distribution was used to represent the uncertainty in the Arnold et al (1993a);(1993b);Tryphonas et al (1989);(1991a); and (1991b). The safety factor consists of a 10-fold factor to account for sensitive individuals, a factor of 10 to account for the use of a LOAEL instead of a NOAEL, and a factor of three to extrapolate from Rhesus monkeys to humans.…”

mentioning

confidence: 99%

Remedial investigation/feasibility study of the Clinch River/Poplar Creek operable unit. Volume 3: Appendixes E and F -- Risk assessment information

1996

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Other than inclusion of an updated executive summary, no substantive changes have been requested or made to this volume from the D2 issue of this document. I 1This document has been approved by the ms 1 E 2 for release to the public. Date: 6/)9/% %=' & , ? ORNL Technical Information OfficeThis report has been reproduced directly from the best available copy. Empirical distribution functions for acute toxicity and chronic toxicity of nickel to fish and invertebrates and individual measurements of nickel in reaches for which potentially significant concentrations were reported ... F2-120Empirical distribution functions for acute toxicity and chronic toxicity of PCBs to fish and invertebrates and individual measurements of PCBs in reaches for which potentially significant concentrations were reported ... F2-121Empirical distribution functions for acute toxicity and chronic toxicity of silver to fish and invertebrates and individual measurements of silver in reaches for which potentially significant concentrations were reported ... F2-122Empirical distribution functions for acute toxicity and chronic toxicity of zinc to fish and invertebrates and individual measurements of zinc in reaches for which potentially significant concentrations were reported ... F2-123Empirical distribution functions for acute toxicity and chronic toxicity of cadmium to aquatic organisms and individual measurements of cadmium in reaches for which potentially significant concentrations were reported .... F3-97Empirical distribution functions for acute toxicity and chronic toxicity of copper to aquatic organisms and individual measurements of copper in reaches for which potentially significant concentrations were reported .... F3-98Empirical distribution functions for acute toxicity and chronic toxicity of mercury to aquatic organisms and individual measurements of mercury Empirical distribution functions for acute toxicity and chronic toxicity of nickel to aquatic organisms and individual measurements of nickel in Empirical distribution functions for acute toxicity and chronic toxicity of zinc to aquatic organisms and individual measurements of zinc in Empirical distribution functions for sediment toxicity of arsenic to sediment-associated organisms and individual measurements of arsenic Empirical distribution functions for sediment toxicity of arsenic to sediment-associated organisms and individual measurements of arsenic in reaches for which potentially significant concentrations were reported .... F3-99reaches for which potentially significant concentrations were reported ..... F3-100reaches for which potentially significant concentrations were reported ..... F3.13(a-b) Empirical distribution functions for sediment toxicity of silver to sedimentassociated organisms and individual measurements of silver in sediments F3.13(c-d) Empirical distribution functions for sediment toxicity of silver to sedimentassociated organisms and individual measurements of silver in sediments F3.14(a-b) Empirical distribution functions for sediment toxicity...

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Toxicological consequences of aroclor 1254 ingestion by female rhesus (macaca mulatta) monkeys. Part 1A. Prebreeding phase: Clinical health findings

Cited by 37 publications

References 38 publications

Remedial investigation/feasibility study for the Clinch River/Poplar Creek operable unit. Volume 3. Appendix E

Remedial investigation/feasibility study for the Clinch River/Poplar Creek operable unit. Volume 3. Appendix E

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Remedial investigation/feasibility study of the Clinch River/Poplar Creek operable unit. Volume 3: Appendixes E and F -- Risk assessment information

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