Toxicological effects of chronic low doses of aflatoxin B1 and fumonisin B1-containing Fusarium moniliforme culture material in weaned piglets

Dilkin, Paulo; Zorzete, Patrícia; Mallmann, Carlos Augusto; Gomes, Jacinta Diva Ferrugem; Utiyama, Carlos Eduardo; Oetting, Liliana Lotufo; Corrêa, Benedito

doi:10.1016/s0278-6915(03)00137-6

Cited by 80 publications

(73 citation statements)

References 35 publications

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“…In our case (see Table 1), there was a mild contamination with DON in C diet. Studying the effects of a co-contamination from AFB 1 and FB 1 in piglets, Dilkin et al (2003) reported no change in leukocyte populations, but evidenced an increase both in RBC and Hct. Contrary to Edrington et al (1994) in growing lambs, we did not observe a specific effect from aflatoxin on Hct and WBC, probably because of our lower mycotoxin concentration.…”

Section: Discussionmentioning

confidence: 99%

Effects of two different blends of naturally mycotoxin-contaminated maize meal on growth and metabolic profile in replacement heifers

Abeni

Migliorati

Terzano

et al. 2014

Animal

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The aim of this trial was to assess the effects of the administration of different combinations of mycotoxins in naturally contaminated maize grains on dairy heifer growth, blood measurements and puberty onset. A total of 35 Friesian female heifers were randomly allotted to three experimental groups from 18-21 to 42-45 weeks of age. During the 24-week experimental period (EP), heifers were fed the same diet, but with maize meal derived from three differently contaminated lots: very low contamination, as control (C); medium-low aflatoxin-contaminated (A); and mixed aflatoxin-fumonisin contaminated (A-F). At the end of the EP, they returned to a common diet without contaminated maize, and they were monitored for an additional period of 12 weeks (postexperimental period, PEP). BW, wither height, hip height, body length and heart girth were measured every 4 weeks from the beginning of EP to the end of PEP. At the same time, body condition score was evaluated and blood samples were taken from the jugular vein to be analysed for haematological, serum protein and metabolic profiles. Age at puberty was assessed by measuring weekly plasma progesterone levels from 40 to 52 weeks of age. Body growth measurements were processed both by ANOVA of average daily gain of EP and PEP separately, and by the analysis of growth curve parameters. Haematological, serum protein and metabolic profile were evaluated using a mixed model, taking into account the repeated measurements in time on each animal. Heifers' growth was delayed both in A and A-F groups during EP, as evidenced by the different linear coefficients of the BW growth curve in the three groups. Differently contaminated diets did not affect the haematological profile, so that it can be concluded that these levels of mycotoxin contamination do not determine any specific effect on haematopoiesis and immunity in growing heifers. The main blood marker of mycotoxin chronic toxicity was the γ-glutamyl transferase activity level in plasma, which appeared to be altered even after the removal of mycotoxins. During EP, plasma glucose was lower in the groups fed contaminated diet compared with C. The joint actions of an altered nutritional status and a long-lasting liver damage were probably the causes of the delay in puberty attainment in A and, particularly, in the A-F group. The results from this trial evidenced that a chronic aflatoxin-fumonisin contamination in diets of dairy heifers can determine an important delay in the reproductive career of these animals.

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Section: Discussionmentioning

confidence: 99%

Effects of two different blends of naturally mycotoxin-contaminated maize meal on growth and metabolic profile in replacement heifers

Abeni

Migliorati

Terzano

et al. 2014

Animal

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“…A literatura demonstra que grande parte dos dados sobre os efeitos das fumonisinas em animais domésticos, incluindo aves, cavalos e suínos, foi obtida utilizando rações mono-contaminada com altas concentrações de FB 1 (Dilkin et al 2003, Direito et al 2009). Os dados deste estudo procurou determinar os efeitos da ingestão sub--crônica de rações contaminadas com níveis baixos de FB 1 no desempenho animal e na histopatologia, visto que os suínos são altamente susceptíveis e estão potencialmente expostos a níveis elevados de FB 1 .…”

Section: Discussionunclassified

“…A fumonisina B 1 (FB 1 ) não interferiu no consumo médio de ração e no ganho de peso corporal. Considerando-se os baixos níveis de contaminação utilizados, nossos dados não são surpreendentes e corroboram os estudos que utilizaram rações contaminadas com 10,0mg FB 1 /kg (Dilkin et al 2003) ou 6,0mg FB 1 /kg (Grenier et al 2011) sobre o desempenho de suínos, os quais não relataram nenhum efeito sobre o ganho de peso corporal. Leitões alimentados com rações que continham de 1,0-10,0 FB 1 mg/kg durante 4-8 semanas, também não apresentaram efeitos tóxicos das fumonisinas (Zomborszky et al 2000, 2002, Dilkin et al 2010.…”

Section: Discussionunclassified

“…No presente estudo, a exposição dos animais a níveis baixos de FB 1 por 28 dias não resultou em alterações nos pesos de órgãos em todos os tratamentos. Dilkin et al (2003) também não encontraram diferenças significativas no peso médio do coração, fígado e pulmões, ao avaliarem o efeito de 10,0mg FB 1 /kg e de 30,0mg FB 1 /kg durante 28 dias de exposição. Em contrapartida, suínos expostos a níveis de 5,0 a 10,0 mg FB 1 /kg de ração, a ingestão da toxina induziu um aumento significativo dose--dependente nos pesos dos pulmões de suínos (Zomborszky et al 2002).…”

Section: Discussionunclassified

“…Contudo, os dados deste estudo não estão de acordo com Zomborszky et al (2000), o qual observaram a presença de edema pulmonar em suínos alimentados com ração contaminada com 5,0mg FB 1 /kg. Ainda, Dilkin et al (2003) descreveram o edema pulmonar durante a exposição de leitões recém-desmamados submetidos a 10,0mg FB 1 /kg na ração.…”

Section: Discussionunclassified

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Ganho de peso, consumo de ração e histologia de órgãos de leitões alimentados com rações contendo baixos níveis de fumonisina B1

Souto

Ramalho

et al. 2015

Pesq. Vet. Bras.

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RESUMO.-A fumonisina B 1 (FB 1 ) é um metabólito secundário produzido principalmente por Fusarium verticilioides em diversos tipos de alimentos, principalmente o milho, o qual constitui a base para composição de rações para várias espécies de animais domésticos. A FB 1 é particularmente tóxica para suínos, cujas manifestações clínicas são evidentes em animais expostos a altas concentrações de FB 1 na ração (em geral, acima de 30mg/kg). No entanto, são escassos os estudos sobre os efeitos da FB 1 em suínos alimentados com rações contendo baixas concentrações de fumonisinas, as quais são mais prováveis de serem encontradas em condições de campo. O objetivo do estudo foi avaliar os efeitos da exposição de leitões a baixos níveis de FB 1 na ra- ) is a secondary metabolite produced mainly by Fusarium verticilioides in several types of foods, particularly corn, which is the basis for composition of feed for several domestic animals. FB 1 is particularly toxic to pigs, being the clinical manifestations evident in animals exposed to high concentrations of FB 1 in the diet (generally above 30mg/kg). However, there are few studies on the effects of FB 1 on pigs fed rations containing low concentrations of fumonisin, which are most probably found under field conditions. The aim of the study was to evaluate the effects of a 28-day exposure of piglets to low levels of FB 1 in the feed on the weight gain, feed consumption, organ weights and histological aspects of the spleen, liver, lungs, kidneys and heart. Twenty-four pigs were assigned into 4 experimental groups and fed diets containing 0mg (control), 3.0mg, 6.0mg or 9.0mg FB 1 /kg diet. The different diets did not affect (P>0.05) the weight gain or the weight of organs examined. There were no macroscopic or histological lesions in the spleen, liver, kidneys and heart. However, histological lesions were found in the lungs from all animals fed rations containing fumonisin, hence indicating that none of the FB 1 levels used in the experiment could be considered as safe for piglets. Further studies on the mechanisms of toxic action of FB 1 in pigs are needed, particularly under conditions of prolonged exposure to low contamination levels in the diet.INDEX TERMS: Fumonisin B 1 , FB 1 , low levels, swine, toxic effects, mycotoxicosis.

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Mycotoxins with a Special Focus on Aflatoxins, Ochratoxins and Fumonisins

Steyn

Gelderblom

Shephard

et al. 2009

General, Applied and Systems Toxicology

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Mycotoxins are important environmental and carcinogenic agents. They are ubiquitous in a broad range of commodities and cause toxic responses when ingested by humans and animals. A review of mycotoxins is presented with special reference to the producing species, analytical methodology, occurrence, biological activity, decontamination, regulations and the risk assessment of aflatoxins, ochratoxins and fumonisins. Some of the most recent studies regarding the mechanisms involved in fumonisin B 1 ‐induced biological effects in different cell culture systems are tabulated. The review is directed at updating the previous review of Steyn and Stander (1999) with a focus on recent findings.

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Toxicological effects of chronic low doses of aflatoxin B1 and fumonisin B1-containing Fusarium moniliforme culture material in weaned piglets

Cited by 80 publications

References 35 publications

Effects of two different blends of naturally mycotoxin-contaminated maize meal on growth and metabolic profile in replacement heifers

Effects of two different blends of naturally mycotoxin-contaminated maize meal on growth and metabolic profile in replacement heifers

Ganho de peso, consumo de ração e histologia de órgãos de leitões alimentados com rações contendo baixos níveis de fumonisina B1

Mycotoxins with a Special Focus on Aflatoxins, Ochratoxins and Fumonisins

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