Toxicological effects of gossypol

Nomeir, Amin A.; Abou‐Donia, Mohamed B.

doi:10.1007/978-94-009-4894-5_9

Cited by 9 publications

(7 citation statements)

References 77 publications

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“…Concerning the high dose of GOS, the increased activity of transaminases was consistent with results elsewhere (Abou-Donia, 1976). This view is supported by the finding of Nomeir and Abou-Donia (1985) that GOS may alter the activity of transaminases by reacting with the substrate and blocking the action of the enzyme and/or by combining with the enzyme itself. Individual fatty acid concentrations (% of the total peak area) in blood plasma at the end of treatment of male rabbits with gossypol and their regression coefficients.…”

Section: Effect Of Level Of Gos On Biochemical Parameters and Electrosupporting

confidence: 89%

Effects of sublethal doses of gossypol on haematological properties and biochemical metabolites of male rabbit

Ramadan

Rashad

2019

World Rabbit Sci.

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The purpose of this study was to investigate the effects of two sublethal doses of gossypol (GOS) (4 and 20 mg/kg of body weight), administered every other day, on some haematological, biochemical, enzymatic and electrolytic properties and amino and fatty acids in male rabbit blood plasma. The experiment lasted for 16 wk and included two phases: 1) administration period; rabbits were given the experimental doses of GOS for 8 wk; and 2) recovery period; rabbits were allowed 8 wk for complete withdrawal of drugs from the plasma. Results showed that low levels of gossypol increased (P<0.01) haemoglobin, mean corpuscular haemoglobin and white blood cells compared to control. Plasma total protein was increased (P<0.01) by the low GOS dose in both experimental phases. Likewise, glucose concentration was increased (P<0.01) by the high GOS dose during the recovery period. Aspartate aminotransferase and alanine aminotransferase enzymes were increased (P<0.01) by the high dose of GOS treatment only. Low GOS dose increased (P<0.01) blood plasma Na + concentration in the recovery period only. Results revealed that total essential amino acids (EAA), and EAA/non-EAA ratio were not affected in a dose-dependent manner during the treatment phase expect for plasma proline, which was increased along with non-EAA (P<0.01) by high GOS dose. Additionally, GOS administration did not affect total unsaturated fatty acids (USFA), total saturated fatty acids (SFA) and SFA/USFA ratio in a dose-dependent manner. In conclusion, Gossypol treatment affected rabbit haematological parameters and biochemical properties of blood plasma in a dosedependent manner.

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Section: Effect Of Level Of Gos On Biochemical Parameters and Electrosupporting

confidence: 89%

Effects of sublethal doses of gossypol on haematological properties and biochemical metabolites of male rabbit

Ramadan

Rashad

2019

World Rabbit Sci.

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“…In this case, the moderately leaked transaminases may be inhibited in the presence of gossypol. This view is supported by the finding of Nomeir and Abou-Donia (45), who reported that gossypol may alter the activity of transaminases by reacting with the substrate and blocking the action of the enzyme and/or by combining with the enzyme itself.…”

Section: Groupmentioning

confidence: 69%

Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma

Shaaban

Taha

El-Nouty

et al. 2008

Fertility and Sterility

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“…Elevations of K (1 1.9 and 7.6 mm/liter) and depressions of chloride (89 and 86 mm/liter) were in two of the moribund calves which otherwise had electrolyte values in the range of the other calves. Total bicarbonate in venous serum was depressed in the three moribund calves (12,13, and 16 mm/liter) compared to control and hospitalized calves (range of 22-29 mmlliter).…”

Section: Resultsmentioning

confidence: 93%

Pathological and Toxicological Studies of Calves Fed a High Concentration Cotton Seed Meal Diet

et al. 1988

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Feeding a high concentration of cotton seed meal to young calves resulted in death with lesions compatible with gossypol toxicity. Calves were fed two different commercially prepared rations. Free gossypol concentrations in different lots of the 17% protein ration varied from 250 to 380 ppm, and the 13% protein ration varied from 40 to 240 ppm. Serum sorbitol dehydrogenase elevation was the most consistent clinical pathological finding. The mean serum sorbitol dehydrogenase concentrations for moribund, hospitalized, and clinically healthy calves were 277, 34, and 45 units/liter. The mean for sorbitol dehydrogenase concentration for healthy calves not fed cotton seed meal was 18 units/liter. Gross lesions included severe effusion of a high protein content fluid into the body cavities of most calves, edema of the mesentery, and hepatomegaly. The most consistent histological lesion was severe centrilobular hepatic necrosis. Elevated levels of liver gossypol were demonstrated. The mean liver gossypol concentration for three calves was 41.7 micrograms/g on a wet weight basis.

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Toxicological effects of gossypol

Cited by 9 publications

References 77 publications

Effects of sublethal doses of gossypol on haematological properties and biochemical metabolites of male rabbit

Effects of sublethal doses of gossypol on haematological properties and biochemical metabolites of male rabbit

Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma

Pathological and Toxicological Studies of Calves Fed a High Concentration Cotton Seed Meal Diet

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