Toxicological effects of <scp><i>Camellia sinensis</i></scp> (green tea): A review

Bedrood, Zeinab; Rameshrad, Maryam; Hosseinzadeh, Hossein

doi:10.1002/ptr.6063

Cited by 110 publications

(97 citation statements)

References 132 publications

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“…From the human consumption perspective, the Food and Drug Administration currently recommends that the total daily consumption of l ‐THE should not exceed 1,200 mg/day for healthy adults. Additionally, these values are further supported by worldwide safe historical consumption of high quantities of GT containing l ‐THE (Bedrood, Rameshrad, & Hosseinzadeh, ; Graham, ).…”

Section: Physical Properties Pharmacokinetics and Toxicity Of L‐thementioning

confidence: 88%

The beneficial health effects of green tea amino acid l‐theanine in animal models: Promises and prospects for human trials

Williams

Sergi

McKune

et al. 2019

Phytotherapy Research

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l‐Theanine (l‐THE) is a nonproteinogenic amino acid derived from green tea (Camellia sinensis), which exhibits strong antioxidant‐like properties and contributes to the favourable umami taste sensation. Several studies have reported that the consumption of this amino acid has many therapeutic effects, including improvements in brain and gastrointestinal function, cancer drug therapeutic efficacies, antihypertensive effects, and improved immune function. Considering the recent Western commercialisation and popularity of green tea consumption as a nootropic agent in humans, the aims of this review were to consolidate the existing knowledge from ex vivo and in vitro animal models and attempt to highlight the applicability of l‐THE towards the human clinical trials. Considering the anti‐inflammatory and antioxidants effects of l‐THE presented in the current review, further research must translate the existing knowledge gained from animal and cell models to exploring the potential metabolic health benefits and moderating effects on the pathogenesis of conditions such as obesity, arthritis, depression, and type 2 diabetes in human trials. This will bridge the gap in literature and provide more insights into the mechanisms driving pathologies characterised by the inflammatory response and oxidative stress.

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Section: Physical Properties Pharmacokinetics and Toxicity Of L‐thementioning

confidence: 88%

The beneficial health effects of green tea amino acid l‐theanine in animal models: Promises and prospects for human trials

Williams

Sergi

McKune

et al. 2019

Phytotherapy Research

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“…The MTS assay showed a decrease of cancer cells viability cultured with both kinds of Pt NPs in comparison with the control; however, 13% and 16% larger decrease is observed for the SW480 and SW620 cells cultured with NPs synthesized by green chemistry. In the literature, anticancer properties of green tea have been reported, which are attributed to the presence of polyphenols, such as epicatechin, epigallocatechin, epicatechin‐3‐gallate, and epigallocatechin‐3‐gallate . Several studies have shown that drinking green tea can prevent carcinogenesis and the development of various types of cancers Moreover, green tea polyphenols are responsible for the regulation of different cancer‐related processes and factors, including DNA methylation and microRNA, histone, and protein modification .…”

Section: Resultsmentioning

confidence: 99%

“…In the literature, anticancer properties of green tea have been reported, which are attributed to the presence of polyphenols, such as epicatechin, epigallocatechin, epicatechin-3-gallate, and epigallocatechin-3-gallate. [60,61] Several studies have shown that drinking green tea can prevent carcinogenesis and the development of various types of cancers [21,[62][63][64] Moreover, green tea polyphenols are responsible for the regulation of different cancer-related processes and factors, including DNA methylation and microRNA, histone, and protein modification. [65,66] Recently, it was shown that green tea plays a very important role in cancer prevention.…”

Section: Viability Changesmentioning

confidence: 99%

Synthesis method‐dependent photothermal effects of colloidal solutions of platinum nanoparticles used in photothermal anticancer therapy

Depciuch

Stec

Maximenko

et al. 2020

Applied Organom Chemis

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One of the most common anticancer therapies is photothermal therapy (PTT). The effectiveness of PTT depends on the photosensitizer being a molecule which is toxic for the cancer cells after electromagnetic wave irradiation. Therefore, a simulation of PTT was performed in this work on two colon cancer cells (SW480 and SW620) using platinum nanoparticles (Pt NPs). Interestingly, in the literature the dependence between the synthesis method and the photothermal properties of Pt NPs was not discussed. Consequently, in this paper, we evaluated the photothermal properties of Pt NPs synthesized by two different methods: polyol (PtI NPs) and green chemistry (PtII NPs). Scanning transmission electron microscopy revealed that the size of both Pt NPs obtained was 2 nm, the NPs were not agglomerated, and that the PtII NPs were distributed on green tea supports. The selected area electron diffraction and X‐ray diffraction analysis confirmed the crystallinity of both types of Pt NPs. Fourier‐transform infrared (FTIR) spectrum of the PtII NPs showed interactions between the NPs and stretching modes for C=O groups from flavonoids and polyphenols. Therefore, these chemical compounds could be responsible for reducing Pt4+ ions to Pt0. Moreover, the 3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazolium (MTS) assay showed that the PtII NPs exhibited 10% and 20% better cytotoxicity effect on SW480 and SW620 cells, than PtI NPs. The viability of cancer cells decreased when Pt NPs were used in PTT. The highest percentage of dead cells (82%) was observed for PtII NPs and 650‐nm laser irradiation. FTIR and Raman spectroscopy showed structural changes induced by both Pt NPs and laser irradiation of cells in the range corresponding to levels of DNA, phospholipids, proteins, and lipids. Moreover, the calculated photothermal conversion efficiency showed that the value of this parameter is around 35%, regardless of the synthesis method and used wavelengths.

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“…The published review articles highlight the potential of green tea and phytoestrogens in breast cancer prevention (Anandhi Senthilkumar, Fata, & Kennelly, ; Najaf Najafi, Salehi, Ghazanfarpour, Hoseini, & Khadem‐Rezaiyan, ; Xiao, Zhang, Tong, & Shi, ). Similarly, there is evidence in the literature that the consumption of both green tea and phytoestrogens‐containing vegetables could be correlated with a low incidence of other chronic pathologies, such as cardiovascular and metabolic diseases (Peluso & Serafini, ; Andrew & Izzo, ; Rietjens, Louisse, & Beekmann, ; Bedrood, Rameshrad, & Hosseinzadeh, ;).…”

mentioning

confidence: 92%