Toxicological effects of WS2 nanomaterials on rice plants and associated soil microbes

Shi, Nibin; Bai, Tonghao; Wang, Xiaojie; Tang, Yuqiong; Wang, Chao; Zhao, Lijuan

doi:10.1016/j.scitotenv.2022.154987

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…Figure 5B shows that the absorption edge of W in rice roots is right-shifted, suggesting that W has been oxidized to a higher valence than WSe 2 , most possibly to tungstate, which is a plantavailable form [36]. This agrees with other studies that found W in rice was in the form of tungstate [37]. Studies have shown that the effects of tungstate on plants are bidirectional.…”

Section: Rice Germination and Hydroponic Cultivationsupporting

confidence: 87%

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

Xue

Xie

et al. 2022

Molecules

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As typical transition metal dichalcogenides (TMDC), tungsten selenide (WSe2) nanosheets (nano-WSe2) are widely used in various fields due to their layered structures and highly tunable electronic and magnetic properties, which results in the unwanted release of tungsten (W) and selenium (Se) into the environment. However, the environmental effects of nano-WSe2 in plants are still unclear. Herein, we evaluated the impacts and fate of nano-WSe2 and micro-WSe2 in rice plants (Oryza sativa L.). It was found that both nano-WSe2 and micro-WSe2 did not affect the germination of rice seeds up to 5000 mg/L but nano-WSe2 affected the growth of rice seedlings with shortened root lengths. The uptake and transportation of WSe2 was found to be size-dependent. Moreover, W in WSe2 was oxidized to tungstate while Se was transformed to selenocysteine, selenomethionine, SeIV and SeVI in the roots of rice when exposed to nano-WSe2, suggesting the transformation of nano-WSe2 in rice plants. The exposure to nano-WSe2 brought lipid peroxidative damage to rice seedlings. However, Se in nano-WSe2 did not contribute to the synthesis of glutathione peroxidase (GSH-Px) since the latter did not change when exposed to nano-WSe2. This is the first report on the impacts and fate of nano-WSe2 in rice plants, which has raised environmental safety concerns about the wide application of TMDCs, such as WSe2 nanosheets.

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Section: Rice Germination and Hydroponic Cultivationsupporting

confidence: 87%

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

Xue

Xie

et al. 2022

Molecules

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“…Potential effects of WS 2 were tested on rice seedlings by exposing them to soil enriched with nanomaterial at different concentrations (10 and 100 mg/ kg). 150 The highest affected root development and induced an oxidative imbalance that caused membrane peroxidation and reduced overall antioxidant capacity of the seedlings. WS 2 also altered the chemical and bacterial microflora of the soil, lowering soil pH and increasing the bioavailability of extractable phosphorus and micronutrients such as Cu, Fe, and Zn.…”

Section: D Materials Impact On Plant Reproductionmentioning

confidence: 99%

“…MoS 2 was also found in leaves. Potential effects of WS 2 were tested on rice seedlings by exposing them to soil enriched with nanomaterial at different concentrations (10 and 100 mg/kg) . The highest affected root development and induced an oxidative imbalance that caused membrane peroxidation and reduced overall antioxidant capacity of the seedlings.…”

Section: D Materials Impact On Plant Reproductionmentioning

confidence: 99%

“…148 Similar results were obtained for WS 2 . 149,150 The metallic phase is characterized by a higher electron conductivity and a higher electron separation efficiency leading to a higher ability to generate oxygen radicals when irradiated with visible light. 149 Similar to GBMs, the size of MoS 2 also matters: single-layer MoS 2 with maximum dimensions in the range of nanometres were less toxic than those in the micrometres because they degraded more rapidly in the growth medium with algae.…”

Section: Impact On Cyanobacteria and Algaementioning

confidence: 99%

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Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Lin,

Buerki-Thurnherr,

Kaur

et al. 2024

ACS Nano

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Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013−2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, socalled green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

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“…(Bolt & Mann, 2016;Lemus & Venezia, 2015;Yu et al, 2023) Owing to its broad use, occupational and environmental exposure to tungsten is increasing and it has been detected in soil, ground sources and potable water. (Du et al, 2022;Keith et al, 2007;Shi et al, 2022) In the clinical setting, it has been reported that patients exposed to treatments based on tungsten display high levels of tungsten in the blood and urine. (Domingo, 2002;Lalak & Moussa, 2002;Tajima, 2001Tajima, , 2003 Notably, it appears that tungsten can bioaccumulate as evidenced in a cohort of breast cancer patients with a tungsten-based shield during intraoperative radiotherapy in which tungsten was detectable in their urine following several months postsurgery.…”

Section: Introductionmentioning

confidence: 99%

Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization

et al. 2023

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Tungsten is widely used in medical, industrial, and military applications. The environmental exposure to tungsten has increased over the past several years and few studies have addressed its potential toxicity.In this study, we evaluated the effects of chronic oral tungsten exposure (100 ppm) on renal in ammation in mice. We found that 30-or 90-day tungsten exposure led to the accumulation of LAMP1-positive lysosomes in renal tubular epithelial cells. In addition, the kidneys of mice exposed to tungsten showed interstitial in ltration of leukocytes, myeloid cells, and macrophages together with increased levels of proin ammatory cytokines and p50/p65-NFkB subunits. In proximal tubule epithelial cells (HK-2) in vitro, tungsten induced a similar in ammatory status characterized by increased mRNA levels of CSF1, IL34, CXCL2 and CXCL10 and NFkB activation. Moreover, tungsten exposure slowed HK-2 cell proliferation and enhanced reactive oxygen species generation. Conditioned media from HK-2 cells treated with tungsten induced an M1-proin ammatory polarization of RAW macrophages as evidenced by increased levels of iNOS and interleukin-6 and decreased levels of the M2-antiin ammatory marker CD206. These effects were not observed when RAW cells were exposed to conditioned media from HK-2 cells treated with tungsten and supplemented with the antioxidant N-acetylcysteine (NAC). Similarly, direct tungsten exposure induced M1-proin ammatory polarization of RAW cells that was prevented by NAC cotreatment. Altogether, our data suggest that prolonged tungsten exposure leads to oxidative injury in the kidney ultimately leading to chronic renal in ammation characterized by a proin ammatory status in kidney tubular epithelial cells and immune cell in ltration.

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Toxicological effects of WS2 nanomaterials on rice plants and associated soil microbes

Cited by 10 publications

References 41 publications

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

Nano-WSe2 Is Absorbable and Transformable by Rice Plants

Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective

Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization

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